GENERATION OF THREE-DIMENSIONAL HUMAN ARTIFICIAL SKELETAL MUSCLE TISSUE FROM IPS CELLS ENABLES COMPLEX DISEASE MODELLING FOR MUSCULAR DYSTROPHY
Journal Article
Maffioletti, S. M., Sarcar, S., Henderson, A., Mannhardt, I., Pinton, L., Moyle, L. A., …Tedesco, F. S. GENERATION OF THREE-DIMENSIONAL HUMAN ARTIFICIAL SKELETAL MUSCLE TISSUE FROM IPS CELLS ENABLES COMPLEX DISEASE MODELLING FOR MUSCULAR DYSTROPHY. Human Gene Therapy, 28(12), A2-A2
All Outputs (89)
Designing translationally relevant preclinical studies of new therapeutics
Journal Article
Wells, D. J. Designing translationally relevant preclinical studies of new therapeutics. Experimental Physiology, 102(6), 616. https://doi.org/10.1113/EP086296
Codon optimisation of microdystrophin improves expression and physiological outcome in dystrophic mdx mice following AAV2/8 gene transfer
Journal Article
Foster, H., Sharp, P., Trollet, C., Athanasopoulos, T., Graham, I., Foster, K., …Dickson, G. Codon optimisation of microdystrophin improves expression and physiological outcome in dystrophic mdx mice following AAV2/8 gene transfer. Molecular Therapy, 16(11), 1825-32. https://doi.org/10.1038/mt.2008.186
Extracellular Release of the Atheroprotective Heat Shock Protein 27 Is Mediated by Estrogen and Competitively Inhibits acLDL Binding to Scavenger Receptor-A
Journal Article
Rayner, K., Chen, Y., McNulty, M., Simard, T., Zhao, X., Wells, D. J., …O'Brien, E. R. Extracellular Release of the Atheroprotective Heat Shock Protein 27 Is Mediated by Estrogen and Competitively Inhibits acLDL Binding to Scavenger Receptor-A. Circulation Research, 103(2), 133-141. https://doi.org/10.1161/CIRCRESAHA.108.172155
Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression
Journal Article
Sharp, P. A., Akbar, T., Bouri, S., Senda, A., Joshi, K., Chen, H. J., …De Belleroche, J. Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression. Neurobiology of Disease, 30(1), 42-55. https://doi.org/10.1016/j.nbd.2007.12.002
Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering
Journal Article
Maffioletti, S. M., Sarcar, S., Henderson, A. B. H., Mannhardt, I., Pinton, L., Moyle, L. A., …Tedesco, F. S. (in press). Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering. Cell Reports, 23(3), 899-908. https://doi.org/10.1016/j.celrep.2018.03.091
Determination of qPCR Reference Genes Suitable for Normalizing Gene Expression in a Canine Model of Duchenne Muscular Dystrophy
Journal Article
Hildyard, J. C. W., Taylor-Brown, F. E., Massey, C., Wells, D. J., & Piercy, R. J. (in press). Determination of qPCR Reference Genes Suitable for Normalizing Gene Expression in a Canine Model of Duchenne Muscular Dystrophy. Journal of Neuromuscular Diseases, 5(2), 177-191. https://doi.org/10.3233/JND-170267Background:Dogs with dystrophin-deficient muscular dystrophy are valuable models of the equivalent human disease, Duchenne Muscular Dystrophy (DMD): unlike the mdx mouse, these animals present a disease severity and progression that closely matches t... Read More about Determination of qPCR Reference Genes Suitable for Normalizing Gene Expression in a Canine Model of Duchenne Muscular Dystrophy.
CHARACTERISING THE SKELETAL MUSCLE HISTOLOGICAL PHENOTYPE OF THE DELTAE50-MD DOG, A PRECLINICAL MODEL OF DUCHENNE MUSCULAR DYSTROPHY
Journal Article
Hildyard, J. C. W., Rawson, F., Harron, R., Riddell, D., Massey, C. A., Taylor-Brown, F. E., …Piercy, R. J. CHARACTERISING THE SKELETAL MUSCLE HISTOLOGICAL PHENOTYPE OF THE DELTAE50-MD DOG, A PRECLINICAL MODEL OF DUCHENNE MUSCULAR DYSTROPHY. Neuromuscular Disorders, 28, S18. https://doi.org/10.1016/S0960-8966%2818%2930342-0
Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons
Journal Article
Kondori, N. R., Paul, P., Robbins, J. P., Liu, K., Hildyard, J. C. W., Wells, D. J., & De Belleroche, J. S. (in press). Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons. PLoS ONE, 12, e0188912. https://doi.org/10.1371/journal.pone.0188912Amyotrophic lateral sclerosis (ALS) is the most common adult-onset neuromuscular disorder characterised by selective loss of motor neurons leading to fatal paralysis. Current therapeutic approaches are limited in their effectiveness. Substantial adva... Read More about Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons.
Muscle moment arms and sensitivity analysis of a mouse hindlimb musculoskeletal model
Journal Article
Charles, J. P., Cappellari, O., Spence, A. J., Wells, D. J., & Hutchinson, J. R. (in press). Muscle moment arms and sensitivity analysis of a mouse hindlimb musculoskeletal model. Journal of Anatomy, 229(4), 514-535. https://doi.org/10.1111/joa.12461
Histopathological Evaluation of Skeletal Muscle with Specific Reference to Mouse Models of Muscular Dystrophy
Journal Article
Terry, R. L., & Wells, D. J. Histopathological Evaluation of Skeletal Muscle with Specific Reference to Mouse Models of Muscular Dystrophy. https://doi.org/10.1002/cpmo.19
Olfaction variation in mouse husbandry and its implications for refinement and standardization: UK survey of animal scents
Journal Article
Lopez-Salesansky, N., Mazlan, N. H., Whitfield, L. E., Wells, D. J., & Burn, C. C. (in press). Olfaction variation in mouse husbandry and its implications for refinement and standardization: UK survey of animal scents. Laboratory Animals, 50(5), 362-369. https://doi.org/10.1177/0023677215622883
THE PHYSIOLOGICAL CONSEQUENCES OF DIFFERENT LEVELS OF DYSTROPHIN FOLLOWING ANTISENSE BASED EXON-SKIPPING IN THE MDX MOUSE
Journal Article
Muses, S., Godfrey, C., McClorey, G., Wells, K. E., Coursindel, T., Terry, R. L., …Wells, D. J. (in press). THE PHYSIOLOGICAL CONSEQUENCES OF DIFFERENT LEVELS OF DYSTROPHIN FOLLOWING ANTISENSE BASED EXON-SKIPPING IN THE MDX MOUSE. Neuromuscular Disorders, 25, S312-S313. https://doi.org/10.1016/j.nmd.2015.06.450We examined the effects on muscle physiology of restoring different levels of dystrophin in mdx mice with established dystrophic pathophysiology (12 weeks and older). Dystrophin expression was induced very efficiently using cell penetrating peptides... Read More about THE PHYSIOLOGICAL CONSEQUENCES OF DIFFERENT LEVELS OF DYSTROPHIN FOLLOWING ANTISENSE BASED EXON-SKIPPING IN THE MDX MOUSE.
Implications for Cardiac Function Following Rescue of the Dystrophic Diaphragm in a Mouse Model of Duchenne Muscular Dystrophy
Journal Article
Betts, C. A., Saleh, A. F., Carr, C. A., Muses, S., Wells, K. E., Hammond, S. M., …Wood, M. J. A. (in press). Implications for Cardiac Function Following Rescue of the Dystrophic Diaphragm in a Mouse Model of Duchenne Muscular Dystrophy. https://doi.org/10.1038/srep11632
Effect of albumin and dextrose concentration on ultrasound and microbubble mediated gene transfection in vivo
Journal Article
Browning, R. J., Mulvana, H., Tang, M. X., Hajnal, J. V., Wells, D. J., & Eckersley, R. J. Effect of albumin and dextrose concentration on ultrasound and microbubble mediated gene transfection in vivo. Ultrasound in Medicine and Biology, 38(6), 1067-77. https://doi.org/10.1016/j.ultrasmedbio.2012.02.020
In silico characterisation and chromosomal localisation of human RRH (peropsin) – implications for opsin evolution
Journal Article
Bellingham, J., Wells, D. J., & Foster, R. G. In silico characterisation and chromosomal localisation of human RRH (peropsin) – implications for opsin evolution. BMC Genomics, 4(1), 3. https://doi.org/10.1186/1471-2164-4-3
MICRO-MINICIRCLE VECTORS FOR SPLICE-SWITCHING IN MOUSE MODEL OF DUCHENNE MUSCULAR DYSTROPHY
Journal Article
Stenler, S., Andaloussi, S. E. L., Hammond, S., Goyenvalle, A., Wwood, M. J. A., Wells, D. J., …Blomberg, P. MICRO-MINICIRCLE VECTORS FOR SPLICE-SWITCHING IN MOUSE MODEL OF DUCHENNE MUSCULAR DYSTROPHY. Human Gene Therapy, 26(10), A77
IMPROVING TRANSLATIONAL STUDIES THROUGH BETTER ANIMAL EXPERIMENTS: LESSONS FROM THE HUMAN RARE DISEASE COMMUNITY
Journal Article
Wells, D. J. IMPROVING TRANSLATIONAL STUDIES THROUGH BETTER ANIMAL EXPERIMENTS: LESSONS FROM THE HUMAN RARE DISEASE COMMUNITY. Disease Models and Mechanisms,
Improving translational studies: lessons from rare neuromuscular diseases
Journal Article
Wells, D. J. Improving translational studies: lessons from rare neuromuscular diseases. Disease Models and Mechanisms, 8(10), 1175-7. https://doi.org/10.1242/dmm.022616
THE TREAT-NMD ADVISORY COMMITTEE FOR THERAPEUTICS (TACT): AN INNOVATIVE DE-RISKING MODEL TO FOSTER ORPHAN DRUG DEVELOPMENT
Journal Article
Wells, D. J., Heslop, E., Csimma, C., Straub, V., McCall, J., Nagaraju, K., …Bushby, K. THE TREAT-NMD ADVISORY COMMITTEE FOR THERAPEUTICS (TACT): AN INNOVATIVE DE-RISKING MODEL TO FOSTER ORPHAN DRUG DEVELOPMENT. Neuromuscular Disorders, 25, S271-S271. https://doi.org/10.1016/j.nmd.2015.06.308