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In cats undergoing midline ovariohysterectomy, is the use of local infiltration anaesthesia with bupivacaine associated with a reduction in post-operative pain score? (2023)
Journal Article
Freeman, T., Wisbey, A., Burroughs, K., Gentle, S., Ellis, C., & Batt-Williams, S. (in press). In cats undergoing midline ovariohysterectomy, is the use of local infiltration anaesthesia with bupivacaine associated with a reduction in post-operative pain score?. Veterinary Evidence, https://doi.org/10.18849/ve.v8i1.552

A knowledge Summary for RCVS knowledge - A student assignment to be published with a member of staff as supervisor In cats undergoing midline ovariohysterectomy, is the use of local infiltration anaesthesia with bupivacaine associated with a red... Read More about In cats undergoing midline ovariohysterectomy, is the use of local infiltration anaesthesia with bupivacaine associated with a reduction in post-operative pain score?.

Novel insights on the effect of sclerostin on bone and other organs (2023)
Journal Article
Dreyer, T., Keen, J., Wells, L., & Roberts, S. (2023). Novel insights on the effect of sclerostin on bone and other organs. Journal of Endocrinology, 257(2), https://doi.org/10.1530/JOE-22-0209

As a key regulator of bone homeostasis, sclerostin has garnered a lot of interest over the last two decades. Although sclerostin is primarily expressed by osteocytes and is well known for its role in bone formation and remodelling, it is also express... Read More about Novel insights on the effect of sclerostin on bone and other organs.

Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathway (2023)
Journal Article
Rickman, M., Ghim, M., Pang, K., von Huelsen Rocha, A. C., Drudi, E. M., Sureda-Vives, M., …Warboys, C. M. (in press). Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathway. Journal of Cell Science, https://doi.org/10.1242/jcs.260449

Multidirectional or disturbed flow promotes endothelial dysfunction and is associated with early atherogenesis. Here we investigated the role of Wnt signalling in flow-mediated endothelial dysfunction. The expression of Frizzled-4 was higher in cultu... Read More about Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathway.

Locomotor and postural diversity among reptiles: palaeobiological implications (2023)
Journal Article
Gônet, J., Bardin, J., Girondot, M., Hutchinson, J., & Laurin, M. (2023). Locomotor and postural diversity among reptiles: palaeobiological implications. Journal of Anatomy, https://doi.org/10.1111/joa.13833

The conquest of land by the first tetrapod vertebrates represents a key stage in their evolution. Selection pressures exerted by this new environment on animals led to the emergence of new locomotor and postural strategies that favoured access to dif... Read More about Locomotor and postural diversity among reptiles: palaeobiological implications.

Comparison of environment quality measurements between 3 types of calf housing in the United Kingdom (2023)
Journal Article
Mahendran, S., Blackie, N., wathes, C., & booth, R. (in press). Comparison of environment quality measurements between 3 types of calf housing in the United Kingdom. Journal of Dairy Science, https://doi.org/10.3168/jds.2022-22613

Pre-weaned calves are kept in a range of housing types which offer variable protection against the weather and provide differing internal environments. This cross-sectional observational study assessed the influence of housing type (shed, polytunnel... Read More about Comparison of environment quality measurements between 3 types of calf housing in the United Kingdom.

Thin and hypokinetic myocardial segments in cats with cardiomyopathy (2023)
Journal Article
Matos, J., Sargent, J., Silva, J., Payne, J., Seo, J., Spalla, I., …Fuentes, V. (2023). Thin and hypokinetic myocardial segments in cats with cardiomyopathy. Journal of Veterinary Cardiology, 46, 5-17. https://doi.org/10.1016/j.jvc.2023.02.002

Introduction/objectives: Thin and hypokinetic myocardial segments (THyMS) represent adverse ventricular (LV) remodeling in human hypertrophic car-diomyopathy. We describe the echocardiographic features and outcome in cats with THyMS, and in a subpopu... Read More about Thin and hypokinetic myocardial segments in cats with cardiomyopathy.

The impact of age-related increase in passive muscle stiffness on simulated upper limb reaching (2023)
Journal Article
Murtola, T., & Richards, C. (2023). The impact of age-related increase in passive muscle stiffness on simulated upper limb reaching. Royal Society Open Science, 10, Article 221453. https://doi.org/10.1098/rsos.221453

Ageing changes the musculoskeletal and neural systems, potentially affecting a person's ability to perform daily living activities. One of these changes is increased passive stiffness of muscles, but its contribution to performance is difficult to se... Read More about The impact of age-related increase in passive muscle stiffness on simulated upper limb reaching.

Pharma-cartography: Navigating the complexities of antibiotic supply to rural livestock in West Bengal, India, through value chain and power dynamic analysis (2023)
Journal Article
Hennessey, M., Ebata, A., Samanta, I., Mateus, A., Arnold, J., Day, D., …Alarcon, P. (in press). Pharma-cartography: Navigating the complexities of antibiotic supply to rural livestock in West Bengal, India, through value chain and power dynamic analysis. PLoS ONE, 18(2), e0281188. https://doi.org/10.1371/journal.pone.0281188

Antibiotic resistance threatens provision of healthcare and livestock production worldwide with predicted negative socioeconomic impact. Antibiotic stewardship can be considered of importance to people living in rural communities, many of which depen... Read More about Pharma-cartography: Navigating the complexities of antibiotic supply to rural livestock in West Bengal, India, through value chain and power dynamic analysis.

Clinical presentation, diagnostic investigations, treatment protocols and outcomes of dogs diagnosed with tick-borne diseases living in the United Kingdom: 76 cases (2005-2019) Animal Health Trust, Newmarket, UK † † (2023)
Journal Article
Silvestrini, P., Lloyd-Bradley, B., Glanemann, B., Barker, E. N., Badham, H., Tappin, S., …Piviani, M. (2023). Clinical presentation, diagnostic investigations, treatment protocols and outcomes of dogs diagnosed with tick-borne diseases living in the United Kingdom: 76 cases (2005-2019) Animal Health Trust, Newmarket, UK † †. Journal of Small Animal Practice, 1-9. https://doi.org/10.1111/jsap.13592

Objectives: To report the presence of tick-borne diseases in dogs living in the United Kingdom. Materials and MethOds: Dogs with a final diagnosis of tick-borne diseases made between January 2005 and August 2019 at seven referral institutions in the... Read More about Clinical presentation, diagnostic investigations, treatment protocols and outcomes of dogs diagnosed with tick-borne diseases living in the United Kingdom: 76 cases (2005-2019) Animal Health Trust, Newmarket, UK † †.

Shear-mediated ALK5 expression regulates endothelial activation (2023)
Journal Article
Pang, K. T., Ghim, M., Sarathchandra, P., Warboys, C. M., Yacoub, M. H., Chester, A. H., & Weinberg, P. D. (2023). Shear-mediated ALK5 expression regulates endothelial activation. Biochemical and Biophysical Research Communications, 642, 90-96. https://doi.org/10.1016/j.bbrc.2022.12.058

Calcific aortic valve disease affects the aortic side of the valve, exposed to low magnitude multidirectional (“disturbed) blood flow, more than it affects the ventricular side, exposed to high magnitude uniaxial flow. Overt disease is preceded by en... Read More about Shear-mediated ALK5 expression regulates endothelial activation.

Tonsillar carcinoma in dogs: Treatment outcome and potential prognostic factors in 123 cases (2023)
Journal Article
Treggiari, E., Pellin, M. A., Romanelli, G., Maresca, G., Gramer, I., Yale, A. D., …Berlato, D. (in press). Tonsillar carcinoma in dogs: Treatment outcome and potential prognostic factors in 123 cases. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16623

Hypothesis/Objectives: Assess treatment outcome and potential prognostic factors in a population of dogs with cytological or histopathological diagnosis of tonsillar carcinoma. Animals: A total of 123 client-owned dogs with diagnosis of tonsillar... Read More about Tonsillar carcinoma in dogs: Treatment outcome and potential prognostic factors in 123 cases.

Risk factors for unilateral cranial cruciate ligament rupture diagnosis and for clinical management in dogs under primary veterinary care in the UK (2023)
Journal Article
Pegram, C., Brodbelt, D., Diaz-Ordaz, K., Chang, Y., Frykfors von Hekkel, A., Church, D., & O'Neill, D. (2023). Risk factors for unilateral cranial cruciate ligament rupture diagnosis and for clinical management in dogs under primary veterinary care in the UK. The Veterinary Journal, https://doi.org/10.1016/j.tvjl.2023.105952

This study aimed to evaluate demographic risk factors associated with unilateral cranial cruciate ligament (CCL) rupture diagnosis and to explore demographic and clinical risk factors associated with management of unilateral CCL rupture in dogs under... Read More about Risk factors for unilateral cranial cruciate ligament rupture diagnosis and for clinical management in dogs under primary veterinary care in the UK.

Doxycycline serum protein binding in pigs reveals a relatively high free fraction (2023)
Journal Article
Felipe Ramon, P., Marlène Z., L., Béatrice B., R., Véronique, G., Pierre-Louis, T., & Bousquet-Mélou, A. (2023). Doxycycline serum protein binding in pigs reveals a relatively high free fraction. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.13111

Doxycycline is an antibiotic widely used in pig farming, which leads to update the doses using PK/PD concepts. However, there is an impasse to estimate the PK/PD cut-off of doxycycline in pigs. Indeed, considering its 7% free fraction and the total s... Read More about Doxycycline serum protein binding in pigs reveals a relatively high free fraction.

Relationships between soil and badger elemental concentrations across a heterogeneously contaminated landscape (2023)
Journal Article
Sartorius, A., Cahoon, M., Corbetta, D., Grau-Roma, L., Johnson, M., Barron, E., …Bennett, M. (2023). Relationships between soil and badger elemental concentrations across a heterogeneously contaminated landscape. Science of the Total Environment, 869, https://doi.org/10.1016/j.scitotenv.2023.161684

Understanding the links between environmental and wildlife elemental concentrations is key to help assess ecosystem functions and the potential effects of legacy pollutants. In this study, livers from 448 European badgers (Meles meles) collected acro... Read More about Relationships between soil and badger elemental concentrations across a heterogeneously contaminated landscape.