Ornithine Phenylacetate targets alterations in the expression and activity of Glutamine Synthase and Glutaminase to reduce ammonia levels in bile duct ligated rats
(2014)
Journal Article
Jover-Cobos, M., Noiret, L., Lee, K. C. L., Sharma, V., Habtesion, A., Romero-Gomez, M., …Jalan, R. (2014). Ornithine Phenylacetate targets alterations in the expression and activity of Glutamine Synthase and Glutaminase to reduce ammonia levels in bile duct ligated rats. Journal of Hepatology, 60(3), 545-553. https://doi.org/10.1016/j.jhep.2013.10.012
Background & Aims: In liver failure, ammonia homeostasis is dependent upon the function of the ammonia metabolising enzymes, glutamine synthetase (GS) and glutaminase (GA) but data about their protein expression and activity are lacking. The aims of... Read More about Ornithine Phenylacetate targets alterations in the expression and activity of Glutamine Synthase and Glutaminase to reduce ammonia levels in bile duct ligated rats.