Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination
(2015)
Journal Article
Natrajan, M. S., De La Fuente, A. G., Crawford, A. H., Lineham, E., Nuñez, V., Johnson, K. R., …Franklin, R. J. (2015). Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination. Brain, 138(Pt12), 3581-97. https://doi.org/10.1093/brain/awv289
The efficiency of central nervous system remyelination declines with age. This is in part due to an age-associated decline in the phagocytic removal of myelin debris, which contains inhibitors of oligodendrocyte progenitor cell differentiation. In th... Read More about Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination.