Polymorphisms in the canine IL7R 3 ' UTR are associated with thymic output in Labrador retriever dogs and influence post-transcriptional regulation by microRNA 185

Holder, A L; Jones, G; Soutter, F; Palmer, D B; Aspinall, R; Catchpole, B

doi:10.1016/j.dci.2017.12.008

All Outputs (5)

A longitudinal study of autoantibodies against cytochrome P450 side-chain cleavage enzyme in dogs (Canis lupus familiaris) affected with hypoadrenocorticism (Addison’s disease) (2018)
Journal Article
Boag, A. M., Christie, M. R., McLaughlin, K. A., Syme, H. M., Graham, P., & Catchpole, B. (2018). A longitudinal study of autoantibodies against cytochrome P450 side-chain cleavage enzyme in dogs (Canis lupus familiaris) affected with hypoadrenocorticism (Addison’s disease). Veterinary Immunology and Immunopathology, 202, 41-45. https://doi.org/10.1016/j.vetimm.2018.05.013

Autoantibodies directed against the P450 side chain cleavage enzyme (P450scc) have been recently described in dogs affected with hypoadrenocorticism, consistent with an immune-mediated pathogenesis of this endocrinopathy. In human autoimmune Addison’... Read More about A longitudinal study of autoantibodies against cytochrome P450 side-chain cleavage enzyme in dogs (Canis lupus familiaris) affected with hypoadrenocorticism (Addison’s disease).

Inconsistent MHC class II association in Beagles experimentally infected with Leishmania infantum (2018)
Journal Article
Soutter, F., Martorell, S., Solano-Gallego, L., & Catchpole, B. (2018). Inconsistent MHC class II association in Beagles experimentally infected with Leishmania infantum. https://doi.org/10.1016/j.tvjl.2018.03.001

The clinical outcome of Leishmania infantum infection in dogs varies from subclinical infection to severe disease. Researchers attribute this variability in clinical manifestations to the ability of the immune response to limit pathogen multiplicatio... Read More about Inconsistent MHC class II association in Beagles experimentally infected with Leishmania infantum.

Perturbation of the T cell receptor repertoire occurs with increasing age in dogs (2018)
Journal Article
Holder, A., Mirczuk, S. M., Fowkes, R. C., Palmer, D. B., Aspinall, R., & Catchpole, B. (2018). Perturbation of the T cell receptor repertoire occurs with increasing age in dogs. Developmental and Comparative Immunology, 79, 150-157. https://doi.org/10.1016/j.dci.2017.10.020

Cryopreservation of canine cardiosphere-derived cells: Implications for clinical application (2018)
Journal Article
Dutton, L. C., Church, S. A. V., Hodgkiss-Geere, H., Catchpole, B., Huggins, A., Dudhia, J., & Connolly, D. J. (2018). Cryopreservation of canine cardiosphere-derived cells: Implications for clinical application. Cytometry Part A, 93A(1), 115-124. https://doi.org/10.1002/cyto.a.23186

Polymorphisms in the canine IL7R 3 ' UTR are associated with thymic output in Labrador retriever dogs and influence post-transcriptional regulation by microRNA 185 (2018)
Journal Article
Holder, A. L., Jones, G., Soutter, F., Palmer, D. B., Aspinall, R., & Catchpole, B. (2018). Polymorphisms in the canine IL7R 3 ' UTR are associated with thymic output in Labrador retriever dogs and influence post-transcriptional regulation by microRNA 185. Developmental and Comparative Immunology, 81, 244-251. https://doi.org/10.1016/j.dci.2017.12.008

Interleukin-7 (IL-7) and its receptor (IL-7R) are essential for T cell development in the thymus, and changes in the IL-7/IL-7R pathway have been implicated in age-associated thymic involution which results in a reduction of naïve T cell output. The... Read More about Polymorphisms in the canine IL7R 3 ' UTR are associated with thymic output in Labrador retriever dogs and influence post-transcriptional regulation by microRNA 185.