All Outputs (4)

The phospholipase A2 pathway controls a synaptic cholesterol ester cycle and synapse damage (2018)
Journal Article
Osborne, C., West, E., & Bate, C. (2018). The phospholipase A2 pathway controls a synaptic cholesterol ester cycle and synapse damage. Journal of Cell Science, 131(8), https://doi.org/10.1242/jcs.211789

The cellular prion protein (PrPC) acts as a scaffold protein that organises signalling complexes. In synaptosomes, the aggregation of PrPC by amyloid-β (Aβ) oligomers attracts and activates cytoplasmic phospholipase A2 (cPLA2), leading to synapse deg... Read More about The phospholipase A2 pathway controls a synaptic cholesterol ester cycle and synapse damage.

Monomeric amyloid-ß reduced amyloid-ß oligomer-induced synapse damage in neuronal cultures (2018)
Journal Article
Bate, C., & Williams, A. (2018). Monomeric amyloid-ß reduced amyloid-ß oligomer-induced synapse damage in neuronal cultures. Neurobiology of Disease, 111, 48-58. https://doi.org/10.1016/j.nbd.2017.12.007

Alzheimer's disease is a progressive neurodegenerative disease characterized by the accumulation of amyloid-β (Aβ) in the brain. Aβ oligomers are believed to cause synapse damage resulting in the memory deficits that are characteristic of this diseas... Read More about Monomeric amyloid-ß reduced amyloid-ß oligomer-induced synapse damage in neuronal cultures.

Cholesterol ester hydrolase inhibitors reduce the production of synaptotoxic amyloid-beta oligomers (2018)
Journal Article
McHale-Owen, H., & Bate, C. (2018). Cholesterol ester hydrolase inhibitors reduce the production of synaptotoxic amyloid-beta oligomers. https://doi.org/10.1016/j.bbadis.2017.12.017

The production of amyloid-β (Aβ) is the key factor driving pathogenesis in Alzheimer's disease (AD). Increasing concentrations of Aβ within the brain cause synapse degeneration and the dementia that is characteristic of AD. Here the factors that affe... Read More about Cholesterol ester hydrolase inhibitors reduce the production of synaptotoxic amyloid-beta oligomers.

Valproic acid and its congener propylisopropylacetic acid reduced the amount of soluble amyloid-ß oligomers released from 7PA2 cells (2018)
Journal Article
Williams, R. S. B., & Bate, C. (2018). Valproic acid and its congener propylisopropylacetic acid reduced the amount of soluble amyloid-ß oligomers released from 7PA2 cells. Neuropharmacology, 128, 54-62. https://doi.org/10.1016/j.neuropharm.2017.09.031

The amyloid hypothesis of Alzheimer's disease suggests that synaptic degeneration and pathology is caused by the accumulation of amyloid-β (Aβ) peptides derived from the amyloid precursor protein (APP). Subsequently, soluble Aβ oligomers cause the lo... Read More about Valproic acid and its congener propylisopropylacetic acid reduced the amount of soluble amyloid-ß oligomers released from 7PA2 cells.