All Outputs (2)

Neuropilin 1 mediates epicardial activation and revascularization in the regenerating zebrafish heart (2019)
Journal Article
Lowe, V., Wisniewski, L., Sayers, J., Evans, I., Frankel, P., Mercader-Huber, N., Zachary, I. C., & Pellet-Many, C. (2019). Neuropilin 1 mediates epicardial activation and revascularization in the regenerating zebrafish heart. Development, 146, https://doi.org/10.1242/dev.174482

Unlike adult mammals, zebrafish can regenerate their heart. A key mechanism for regeneration is the activation of the epicardium, leading to the establishment of a supporting scaffold for new cardiomyocytes, angiogenesis and cytokine secretion. Neuro... Read More about Neuropilin 1 mediates epicardial activation and revascularization in the regenerating zebrafish heart.

Smooth muscle cell-specific knockout of neuropilin-1 impairs postnatal lung development and pathological vascular smooth muscle cell accumulation (2019)
Journal Article
Mahmoud, M., Evans, I. M., Mehta, V., Pellet-Many, C., Paliashvili, K., & Zachary, I. (2019). Smooth muscle cell-specific knockout of neuropilin-1 impairs postnatal lung development and pathological vascular smooth muscle cell accumulation. https://doi.org/10.1152/ajpcell.00405.2018

Neuropilin 1 (NRP1) is important for neuronal and cardiovascular development due to its role in conveying class 3 semaphorin and vascular endothelial growth factor signaling, respectively. NRP1 is expressed in smooth muscle cells (SMCs) and mediates... Read More about Smooth muscle cell-specific knockout of neuropilin-1 impairs postnatal lung development and pathological vascular smooth muscle cell accumulation.