All Outputs (2)

Extracellular Nucleotides Regulate Arterial Calcification by Activating Both Independent and Dependent Purinergic Receptor Signaling Pathways (2020)
Journal Article
Opdebeeck, B., Orriss, I., Neven, E., D’Haese, P. C., & Verhulst, A. (2020). Extracellular Nucleotides Regulate Arterial Calcification by Activating Both Independent and Dependent Purinergic Receptor Signaling Pathways. International Journal of Molecular Sciences, 21(20), e7636

Arterial calcification, the deposition of calcium-phosphate crystals in the extracellular matrix, resembles physiological bone mineralization. It is well-known that extracellular nucleotides regulate bone homeostasis raising an emerging interest in t... Read More about Extracellular Nucleotides Regulate Arterial Calcification by Activating Both Independent and Dependent Purinergic Receptor Signaling Pathways.

Extracellular pyrophosphate: The body's “water softener” (2020)
Journal Article
Orriss, I. R. (2020). Extracellular pyrophosphate: The body's “water softener”. BONE, https://doi.org/10.1016/j.bone.2020.115243

Extracellular pyrophosphate (ePPi) was first identified as a key endogenous inhibitor of mineralisation in the 1960's by Fleisch and colleagues. The main source of ePPi seems to be extracellular ATP which is continually released from cells in a contr... Read More about Extracellular pyrophosphate: The body's “water softener”.