All Outputs (5)

Validating an empiric sulfadiazine–trimethoprim dosage regimen for treatment of Escherichia coli and Staphylococcus delphini infections in mink ( Neovison vison ) (2020)
Journal Article
Ronaghinia, A. A., Nikolaisen, N. K., Hansen, S. G., Poulsen, H. H., Frandsen, H. L., Struve, T., Toutain, P. L., & Damborg, P. (2020). Validating an empiric sulfadiazine–trimethoprim dosage regimen for treatment of Escherichia coli and Staphylococcus delphini infections in mink ( Neovison vison ). Journal of Veterinary Pharmacology and Therapeutics,

Antimicrobial agents are used extensively off‐label in mink, as almost no agents are registered for this animal species. Pharmacokinetic (PK) and pharmacodynamic (PD) data are required to determine antimicrobial dosages specifically targeting mink ba... Read More about Validating an empiric sulfadiazine–trimethoprim dosage regimen for treatment of Escherichia coli and Staphylococcus delphini infections in mink ( Neovison vison ).

A history of antimicrobial drugs in animals: Evolution and revolution (2020)
Journal Article
Lees, P., Pelligand, L., Giraud, E., & Toutain, P. (2020). A history of antimicrobial drugs in animals: Evolution and revolution. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.12895

The evolutionary process of antimicrobial drug (AMD) uses in animals over a mere eight decades (1940–2020) has led to a revolutionary outcome, and both evolution and revolution are ongoing, with reports on a range of uses, misuses and abuses escalati... Read More about A history of antimicrobial drugs in animals: Evolution and revolution.

A New Drug–Drug Interaction Between Hydroxychloroquine and Metformin? A Signal Detection Study (2020)
Journal Article
Montastruc, J. L., & Toutain, P. L. (2020). A New Drug–Drug Interaction Between Hydroxychloroquine and Metformin? A Signal Detection Study. Drug Safety, 43(7), 657-660. https://doi.org/10.1007/s40264-020-00955-y

Introduction
Hydroxychloroquine was recently promoted in patients infected with COVID-19 infection. A recent experimental study has suggested an increased toxicity of hydroxychloroquine in association with metformin in mice.

Objective
The presen... Read More about A New Drug–Drug Interaction Between Hydroxychloroquine and Metformin? A Signal Detection Study.

Toxicokinetics of bisphenol-S and its glucuronide in plasma and urine following oral and dermal exposure in volunteers for the interpretation of biomonitoring data (2020)
Journal Article
Khmiri, I., Côté, J., Mantha, M., Khemiri, R., Lacroix, M., Gely, C., Toutain, P.-L., Picard-Hagen, N., Gayrard, M., & Bouchard, M. (2020). Toxicokinetics of bisphenol-S and its glucuronide in plasma and urine following oral and dermal exposure in volunteers for the interpretation of biomonitoring data. Environment International, 138, https://doi.org/10.1016/j.envint.2020.105644

The measurement of bisphenol-S (BPS) and its glucurono-conjugate (BPSG) in urine may be used for the biomonitoring of exposure in populations. However, this requires a thorough knowledge of their toxicokinetics. The time courses of BPS and BPSG were... Read More about Toxicokinetics of bisphenol-S and its glucuronide in plasma and urine following oral and dermal exposure in volunteers for the interpretation of biomonitoring data.

Toxicokinetics of bisphenol-S and its glucuronide in plasma and urine following oral and dermal exposure in volunteers for the interpretation of biomonitoring data (2020)
Journal Article
Khmiri, I., Côté, J., Mantha, M., Khemiri, R., Lacroix, M., Gely, C., Toutain, P.-L., Picard-Hagen, N., Gayrard, V., & Bouchard, M. (2020). Toxicokinetics of bisphenol-S and its glucuronide in plasma and urine following oral and dermal exposure in volunteers for the interpretation of biomonitoring data. Environment International, 138, 105644. https://doi.org/10.1016/j.envint.2020.105644

The measurement of bisphenol-S (BPS) and its glucurono-conjugate (BPSG) in urine may be used for the biomonitoring of exposure in populations. However, this requires a thorough knowledge of their toxicokinetics. The time courses of BPS and BPSG were... Read More about Toxicokinetics of bisphenol-S and its glucuronide in plasma and urine following oral and dermal exposure in volunteers for the interpretation of biomonitoring data.