Glomerulonephritis and autoimmune vasculitis are independent of P2RX7 but may depend on alternative inflammasome pathways

Prendecki, M; McAdoo, SP; Turner-Stokes, T; Garcia-Diaz, A; Orriss, I; Woollard, KJ; Behmoaras, J; Cook, HT; Unwin, R; Pusey, CD; Aitman, TJ; Tam, FWK

doi:10.1002/path.5890

All Outputs (3)

Deletion of the P2Y(2) receptor aggravates internal elastic lamina calcification in chronic kidney disease mice through upregulation of alkaline phosphatase and lipocalin-2 (2022)
Journal Article
Opdebeeck, B., Huysmans, I., van den Branden, A., Orriss, I., D'Haese, P., & Verhulst, A. (2023). Deletion of the P2Y(2) receptor aggravates internal elastic lamina calcification in chronic kidney disease mice through upregulation of alkaline phosphatase and lipocalin-2. FASEB Journal, 37(1), https://doi.org/10.1096/fj.202201044R

Calcification of the medial layer, inducing arterial stiffness, contributes significantly to cardiovascular mortality in patients with chronic kidney disease (CKD). Extracellular nucleotides block the mineralization of arteries by binding to purinerg... Read More about Deletion of the P2Y(2) receptor aggravates internal elastic lamina calcification in chronic kidney disease mice through upregulation of alkaline phosphatase and lipocalin-2.

Modulation of osteoblast differentiation and function by the P2X4 receptor (2022)
Journal Article
Orriss, I., Davies, B. K., Bourne, L. E., & Arnett, T. R. (2022). Modulation of osteoblast differentiation and function by the P2X4 receptor. Purinergic Signalling, https://doi.org/10.1007/s11302-022-09887-x

Glomerulonephritis and autoimmune vasculitis are independent of P2RX7 but may depend on alternative inflammasome pathways (2022)
Journal Article
Prendecki, M., McAdoo, S., Turner-Stokes, T., Garcia-Diaz, A., Orriss, I., Woollard, K., …Tam, F. (2022). Glomerulonephritis and autoimmune vasculitis are independent of P2RX7 but may depend on alternative inflammasome pathways. Journal of Pathology, 257(3), 300-313. https://doi.org/10.1002/path.5890

P2RX7, an ionotropic receptor for extracellular adenosine triphosphate (ATP), is expressed on immune cells, including macrophages, monocytes, and dendritic cells and is upregulated on nonimmune cells following injury. P2RX7 plays a role in many biolo... Read More about Glomerulonephritis and autoimmune vasculitis are independent of P2RX7 but may depend on alternative inflammasome pathways.