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Pharmacological advances in mitochondrial therapy (2021)
Journal Article
Singh, A., Faccenda, D., & Campanella, M. (2021). Pharmacological advances in mitochondrial therapy. EBioMedicine, 65, https://doi.org/10.1016/j.ebiom.2021.103244

Mitochondria play a vital role in cellular metabolism and are central mediator of intracellular signalling, cell differentiation, morphogenesis and demise. An increasingly higher number of pathologies is linked with mitochondrial dysfunction, which c... Read More about Pharmacological advances in mitochondrial therapy.

Long-term outcome and quality of life of dogs that developed neurologic signs after surgical treatment of a congenital portosystemic shunt: 50 cases (2005-2020) (2021)
Journal Article
Carrera, A., Morrissey, A., Lipscomb, V., Tivers, M., Chan, A., Pisco, V., …Mullins, R. (2021). Long-term outcome and quality of life of dogs that developed neurologic signs after surgical treatment of a congenital portosystemic shunt: 50 cases (2005-2020). Journal of the American Veterinary Medical Association, 260(3), 326-334. https://doi.org/10.2460/javma.20.11.0606

OBJECTIVE To determine survival time and quality of life of dogs that developed postattenuation neurologic signs (PANS) after surgical treatment of a single congenital portosystemic shunt and survived at least 30 days and identify whether neurologic... Read More about Long-term outcome and quality of life of dogs that developed neurologic signs after surgical treatment of a congenital portosystemic shunt: 50 cases (2005-2020).

Common Traits Spark the Mitophagy/Xenophagy Interplay (2018)
Journal Article
Singh, A., Kendall, S. L., & Campanella, M. (2018). Common Traits Spark the Mitophagy/Xenophagy Interplay. Frontiers in Physiology, 9, https://doi.org/10.3389/fphys.2018.01172

Selective autophagy contributes to the wellbeing of eukaryotic cells by recycling cellular components, disposing damaged organelles, and removing pathogens, amongst others. Both the quality control process of selective mitochondrial autophagy (Mitoph... Read More about Common Traits Spark the Mitophagy/Xenophagy Interplay.

Heteromeric RNP Assembly at LINEs Controls Lineage-Specific RNA Processing (2018)
Journal Article
Attig, J., Agostini, F., Gooding, C., Chakrabarti, A. M., Singh, A., Haberman, N., …Ule, J. (2018). Heteromeric RNP Assembly at LINEs Controls Lineage-Specific RNA Processing. Cell, https://doi.org/10.1016/j.cell.2018.07.001

Long mammalian introns make it challenging for the RNA processing machinery to identify exons accurately. We find that LINE-derived sequences (LINEs) contribute to this selection by recruiting dozens of RNA-binding proteins (RBPs) to introns. This in... Read More about Heteromeric RNP Assembly at LINEs Controls Lineage-Specific RNA Processing.

A role for TSPO in mitochondrial Ca2+ homeostasis and redox stress signaling (2017)
Journal Article
Gatliff, J., East, D. A., Singh, A., Alvarez, M. S., Frison, M., Matic, I., …Campanella, M. (2017). A role for TSPO in mitochondrial Ca2+ homeostasis and redox stress signaling. https://doi.org/10.1038/cddis.2017.186

The 18?kDa translocator protein TSPO localizes on the outer mitochondrial membrane (OMM). Systematically overexpressed at sites of neuroinflammation it is adopted as a biomarker of brain conditions. TSPO inhibits the autophagic removal of mitochondri... Read More about A role for TSPO in mitochondrial Ca2+ homeostasis and redox stress signaling.