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Welcome to RVC Repository

RVC Research Online compiles the research outputs of academics and clinical staff from the Royal Veterinary College.
The aim of the repository is to: provide a long-term home for research outputs from the College; supply access to full-text versions of these outputs; support the practice of open science across the entire range of the College's research activity; and, increase the impact and reach of the College's research.



Latest Additions

Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor (2022)
Journal Article
Miller, D., Reuillon, T., Molyneux, L., Blackburn, T., Cook, S., Edwards, N., …Cano, C. (2022). Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor. Journal of Medicinal Chemistry, 65(9), 6513-6540. https://doi.org/10.1021/acs.jmedchem.1c01756

The nonclassical extracellular signal-related kinase 5 (ERK5) mitogen-activated protein kinase pathway has beenimplicated in increased cellular proliferation, migration, survival, and angiogenesis; hence, ERK5 inhibition may be an attractiveapproach... Read More about Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor.

Modelling livestock test-and-treat: A novel One Health strategy to control schistosomiasis and mitigate drug resistance (2022)
Journal Article
Díaz, A. V., Lambert, S., Neves, M. I., Borlase, A., Léger, E., Diouf, N. D., …Walker, M. (2022). Modelling livestock test-and-treat: A novel One Health strategy to control schistosomiasis and mitigate drug resistance. Frontiers in Tropical Diseases, 3, 1-12. https://doi.org/10.3389/fitd.2022.893066

Schistosomiasis, a neglected tropical disease, is a widespread chronic helminthiasis reported in 78 countries, predominantly those within sub-Saharan Africa, as well as Latin America, Asia, and most recently, even Europe. Species of the causative blo... Read More about Modelling livestock test-and-treat: A novel One Health strategy to control schistosomiasis and mitigate drug resistance.

Surveillance and control of SARS-CoV-2 in mustelids: An evolutionary perspective (2021)
Journal Article
Diaz, A., Walker, M., & Webster, J. (2021). Surveillance and control of SARS-CoV-2 in mustelids: An evolutionary perspective. Evolutionary Applications, https://doi.org/10.1111/eva.13310

The relevance of mustelids in SARS-CoV-2 transmission has become increasingly evident. Alongside experimental demonstration of airborne transmission among ferrets, the major animal model for human respiratory diseases, transmission of SARS-CoV-2 with... Read More about Surveillance and control of SARS-CoV-2 in mustelids: An evolutionary perspective.

Antimicrobial use for the treatment of canine pyoderma: a protocol for a systematic review
Other
Frosini, S., & Loeffler, A. Antimicrobial use for the treatment of canine pyoderma: a protocol for a systematic review. [Method article]

This protocol details the methodology to conduct a systematic review to critically evaluate the quality of evidence surrounding the use of antimicrobials (both systemic and topical) to treat canine superficial or deep pyoderma. This systematic revi... Read More about Antimicrobial use for the treatment of canine pyoderma: a protocol for a systematic review.