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Association of the TTN, PDK4, and RNF207 mutations with dilated cardiomyopathy in Dobermanns from the United Kingdom (2025)
Journal Article
Dutton, L., Crossland, A., Dukes-McEwan, J., & Connolly, D. (2025). Association of the TTN, PDK4, and RNF207 mutations with dilated cardiomyopathy in Dobermanns from the United Kingdom. PLoS ONE, 2025 Mar 13;20(3):e0319932, https://doi.org/10.1371/journal.pone.0319932

A missense mutation in the titin gene (TTN) and a splice-site mutation in the pyruvate dehydrogenase kinase 4 gene (PDK4) have been associated with dilated cardiomyopathy (DCM) in Dobermanns from the United States. Additionally, a missense mutation i... Read More about Association of the TTN, PDK4, and RNF207 mutations with dilated cardiomyopathy in Dobermanns from the United Kingdom.

Analysis of Cattle Foot Lesions Recorded at Trimming in the Southwest of England (2025)
Journal Article
Britten, N., Blackie, N., Reader, J., Booth, R. E., & Mahendran, S. A. (in press). Analysis of Cattle Foot Lesions Recorded at Trimming in the Southwest of England. Animals, 15(6), 829. https://doi.org/10.3390/ani15060829

Background: The UK has a high incidence of lameness in cattle, which is costly in terms of economics and welfare. Most causes of bovine lameness originate in the foot but there are several different conditions causing lameness. Quantifying the relati... Read More about Analysis of Cattle Foot Lesions Recorded at Trimming in the Southwest of England.

The microRNA-455 null mouse shows dysregulated bone turnover (2025)
Journal Article
Niu, L., Swingler, T., Suelzu, C., Ersek, A., Orriss, I., Barter, M., Hayman, D., Young, D., Horwood, N., & Clark, I. (2025). The microRNA-455 null mouse shows dysregulated bone turnover. JBMR Plus, 9(3), https://doi.org/10.1093/jbmrpl/ziaf007

A wide range of specific microRNAs have been shown to have either positive or negative effects on osteoblast differentiation and function, with consequent changes in postnatal bone mass. A number of specific targets have been identified. We previousl... Read More about The microRNA-455 null mouse shows dysregulated bone turnover.

Transmission dynamics of highly pathogenic avian influenza among multiple waterfowl species and backyard poultry: the impact of the stopover period (2025)
Journal Article
Llanos-Soto, S., Yaffy, D., Pavlak, M., & Ivanek, R. (2025). Transmission dynamics of highly pathogenic avian influenza among multiple waterfowl species and backyard poultry: the impact of the stopover period. Scientific Reports, 15(1), https://doi.org/10.1038/s41598-025-89827-y

Spillover of Highly Pathogenic Avian Influenza (HPAI) to backyard poultry via migratory birds threatens the poultry industry and public health. To improve the understanding of spillover events, we developed a stochastic compartmental mathematical mod... Read More about Transmission dynamics of highly pathogenic avian influenza among multiple waterfowl species and backyard poultry: the impact of the stopover period.

Engineered pulmonary artery tissues for measuring contractility, drug testing and disease modelling (2025)
Journal Article
Fellows, A., Quigley, K., Leung, V., Ainscough, A., Wilkins, M., Barnett, H., Miller, D., Mayr, M., & Wojciak-Stothard, B. (2025). Engineered pulmonary artery tissues for measuring contractility, drug testing and disease modelling. British Journal of Pharmacology, https://doi.org/10.1111/bph.17462

Background and PurposeVasoreactivity of pulmonary arteries regulates blood flow through the lungs. Excessive constriction of these vessels contributes to pulmonary arterial hypertension (PAH), a progressive and incurable condition, resulting in right... Read More about Engineered pulmonary artery tissues for measuring contractility, drug testing and disease modelling.