OVER EXPRESSION OF THE LARGE TRANSGENE EXACERBATES MUSCLE PATHOLOGY IN THE MDX MOUSE
Journal Article
Wells, K. E., Muses, S., Ruberg, A., Terry, R., Shihab, N. K., & Wells, D. J. OVER EXPRESSION OF THE LARGE TRANSGENE EXACERBATES MUSCLE PATHOLOGY IN THE MDX MOUSE. Neuromuscular Disorders, 22(9-10), 813-813. https://doi.org/10.1016/j.nmd.2012.06.039
ASSESSING THE LONG TERM EXPRESSION OF LARGE AS A POTENTIAL THERAPY IN A MOUSE MODEL OF LGMD2I
Journal Article
Whitmore, C., Booler, H., Parr, C., Ackroyd, M. R., Fernandez-Fuente, M., Muntoni, F., …Brown, S. C. ASSESSING THE LONG TERM EXPRESSION OF LARGE AS A POTENTIAL THERAPY IN A MOUSE MODEL OF LGMD2I. Neuromuscular Disorders, 22(9-10), 813-814. https://doi.org/10.1016/j.nmd.2012.06.040
Influence of needle gauge on in vivo ultrasound and microbubble-mediated gene transfection
Journal Article
Browning, R. J., Mulvana, H., Tang, M. X., Hajnal, J. V., Wells, D. J., & Eckersley, R. J. Influence of needle gauge on in vivo ultrasound and microbubble-mediated gene transfection. Ultrasound in Medicine and Biology, 37(9), 1531-1537. https://doi.org/10.1016/j.ultrasmedbio.2011.05.019
Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-esclation study
Journal Article
Cirak, S., Arechavala-Gomeza, V., Guglieri, M., Feng, L., Torelli, S., Anthony, K., …Muntoni, F. Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-esclation study. https://doi.org/10.1016/S0140-6736%2811%2960756-3
EXON SKIPPING AND DYSTROPHIN RESTORATION IN DUCHENNE MUSCULAR DYSTROPHY PATIENTS AFTER SYSTEMIC PHOSPHORODIAMIDATE MORPHOLINO OLIGOMER TREATMENT
Journal Article
Cirak, S., Arechavala-Gomeza, V., Guglieri, M., Feng, L., Torelli, S., Anthony, K., …Muntoni, F. EXON SKIPPING AND DYSTROPHIN RESTORATION IN DUCHENNE MUSCULAR DYSTROPHY PATIENTS AFTER SYSTEMIC PHOSPHORODIAMIDATE MORPHOLINO OLIGOMER TREATMENT. Neuromuscular Disorders, 21(1), S7-S8
Metformin Treatment Has No Beneficial Effect in a Dose-Response Survival Study in the SOD1(G93A) Mouse Model of ALS and Is Harmful in Female Mice
Journal Article
Kaneb, H. M., Sharp, P. S., Rahmani-Kondori, N., & Wells, D. J. Metformin Treatment Has No Beneficial Effect in a Dose-Response Survival Study in the SOD1(G93A) Mouse Model of ALS and Is Harmful in Female Mice. PLoS ONE, 6(9), e24189. https://doi.org/10.1371/journal.pone.0024189
Chronic Systemic Therapy With Low-dose Morpholino Oligomers Ameliorates the Pathology and Normalizes Locomotor Behavior in mdx Mice
Journal Article
Malerba, A., Graham, I., Sharp, P., Popplewell, L., Foster, K., Wells, D. J., & Dickson, G. Chronic Systemic Therapy With Low-dose Morpholino Oligomers Ameliorates the Pathology and Normalizes Locomotor Behavior in mdx Mice. Molecular Therapy, 19(2), 345-54. https://doi.org/10.1038/mt.2010.261
In vivo fluorescence lifetime tomography of a FRET probe expressed in mouse
Journal Article
McGinty, J., Stuckey, D. W., Solovjev, V. Y., Wylezinska-Arridge, M., Wells, D. J., Arridge, S. R., …Sardini, A. In vivo fluorescence lifetime tomography of a FRET probe expressed in mouse. Biomedical Optics Express, 2(7), 1907-1917. https://doi.org/10.1364/BOE.2.001907
Muscular dystrophies due to glycosylation defects: diagnosis and therapeutic strategies
Journal Article
Muntoni, F., Torelli, S., Wells, D. J., & Brown, S. C. Muscular dystrophies due to glycosylation defects: diagnosis and therapeutic strategies. Current Opinion in Neurology, 24(5), 437-442. https://doi.org/10.1097/WCO.0b013e32834a95e3
ARE LARGE-IN-FRAME DUPLICATIONS OF DYSTROPHIN FUNCTIONAL?
Journal Article
Muses, S., Jones, H., & Wells, D. J. ARE LARGE-IN-FRAME DUPLICATIONS OF DYSTROPHIN FUNCTIONAL?. Neuromuscular Disorders, 21(9-10), 713-714. https://doi.org/10.1016/j.nmd.2011.06.997
A New Extensively Characterised Conditionally Immortal Muscle Cell-Line for Investigating Therapeutic Strategies in Muscular Dystrophies
Journal Article
Muses, S., Morgan, J. E., & Wells, D. J. A New Extensively Characterised Conditionally Immortal Muscle Cell-Line for Investigating Therapeutic Strategies in Muscular Dystrophies. PLoS ONE, 6(9), e24826. https://doi.org/10.1371/journal.pone.0024826
Restoration of dystrophin expression using the Sleeping Beauty transposon
Journal Article
Muses, S., Morgan, J. E., & Wells, D. J. Restoration of dystrophin expression using the Sleeping Beauty transposon. https://doi.org/10.1371/currents.RRN1296
Physiological Characterization of muscle strength with variable levels of Dystrophin Restoration in mdx Mice following local antisense therapy
Journal Article
Sharp, P. S., Bye-a-Jee, H., & Wells, D. J. Physiological Characterization of muscle strength with variable levels of Dystrophin Restoration in mdx Mice following local antisense therapy. Molecular Therapy, 19(1), 165-171. https://doi.org/10.1038/mt.2010.213
Forster resonance energy transfer imaging in vivo with approximated radiative transfer equation
Journal Article
Soloviev, V. Y., McGinty, J., Stuckey, D. W., Laine, R., Wylezinska-Arridge, M., Wells, D. J., …Arridge, S. R. Forster resonance energy transfer imaging in vivo with approximated radiative transfer equation. Applied Optics, 50(36), 6583-6590
Animal welfare and the 3Rs in European biomedical research
Book Chapter
Wells, D. J. Animal welfare and the 3Rs in European biomedical research. . https://doi.org/10.1111/j.1749-6632.2011.06335.x
OUTCOME MEASURES IN THE MDX MOUSE
Journal Article
Wells, D. J. OUTCOME MEASURES IN THE MDX MOUSE. Neuromuscular Disorders, 21, S5-S5
ASSESSING THE THERAPEUTIC POTENTIAL OF LARGE IN A NEW MOUSE MODEL OF DYSTROGLYCANOPATHY
Journal Article
Whitmore, C., Ackroyd, M. R., Muses, S., Ashraf, A., Muntoni, F., Brown, S. C., & Wells, D. J. ASSESSING THE THERAPEUTIC POTENTIAL OF LARGE IN A NEW MOUSE MODEL OF DYSTROGLYCANOPATHY. Neuromuscular Disorders, 21(9-10), 665-665. https://doi.org/10.1016/j.nmd.2011.06.838
Electroporation and ultrasound enhanced non-viral gene delivery in vitro and in vivo
Journal Article
Wells, D. J. Electroporation and ultrasound enhanced non-viral gene delivery in vitro and in vivo. Cell Biology and Toxicology, 26(1), 21-28. https://doi.org/10.1007/s10565-009-9144-8
Genetically modified animals and pharmacological research
Book Chapter
Wells, D. J. Genetically modified animals and pharmacological research. . https://doi.org/10.1007/978-3-642-10324-7_9
MAKING SENSE IN DUCHENNE MUSCULAR DYSTROPHY
Journal Article
Wells, D. J. MAKING SENSE IN DUCHENNE MUSCULAR DYSTROPHY. Human Gene Therapy, 21(4), 495-495
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