Pretectal projections to the oculomotor cerebellum in hummingbirds ( Calypte anna ), zebra finches ( Taeniopygia guttata ), and pigeons ( Columba livia ) (2019)
Journal Article
Gaede, A. H., Gutierrez‐Ibanez, C., Armstrong, M. S., Altshuler, D. L., & Wylie, D. R. (2019). Pretectal projections to the oculomotor cerebellum in hummingbirds ( Calypte anna ), zebra finches ( Taeniopygia guttata ), and pigeons ( Columba livia ). Journal of Comparative Neurology, 527(16), 2644-2658. https://doi.org/10.1002/cne.24697

In birds, optic flow is processed by a retinal‐recipient nucleus in the pretectum, the nucleus lentiformis mesencephali (LM), which then projects to the cerebellum, a key site for sensorimotor integration. Previous studies have shown that the LM is h... Read More about Pretectal projections to the oculomotor cerebellum in hummingbirds ( Calypte anna ), zebra finches ( Taeniopygia guttata ), and pigeons ( Columba livia ).

Relating neuromuscular control to functional anatomy of limb muscles in extant archosaurs (2019)
Journal Article
Cuff, A. R., Daley, M. A., Michel, K. B., Allen, V. R., Lamas, L. P., Adami, C., …Hutchinson, J. R. (2019). Relating neuromuscular control to functional anatomy of limb muscles in extant archosaurs. Journal of Morphology, 280(5), 666-680. https://doi.org/10.1002/jmor.20973

Electromyography (EMG) is used to understand muscle activity patterns in animals. Understanding how much variation exists in muscle activity patterns in homologous muscles across animal clades during similar behaviours is important for evaluating the... Read More about Relating neuromuscular control to functional anatomy of limb muscles in extant archosaurs.

Terrestrial mammalian wildlife responses to Unmanned Aerial Systems approaches (2019)
Journal Article
Bennitt, E., Bartlam-Brooks, H. L. A., Hubel, T. Y., & Wilson, A. M. (2019). Terrestrial mammalian wildlife responses to Unmanned Aerial Systems approaches. https://doi.org/10.1038/s41598-019-38610-x

Unmanned Aerial Systems (UAS) are increasingly being used recreationally, commercially and for wildlife research, but very few studies have quantified terrestrial mammalian reactions to UAS approaches. We used two Vertical Take-off and Landing (VTOL)... Read More about Terrestrial mammalian wildlife responses to Unmanned Aerial Systems approaches.

The running kinematics of free-roaming giraffes, measured using a low cost unmanned aerial vehicle (UAV) (2019)
Journal Article
Basu, C. K., Deacon, F., Hutchinson, J. R., & Wilson, A. M. (2019). The running kinematics of free-roaming giraffes, measured using a low cost unmanned aerial vehicle (UAV). PeerJ, 7, e6312. https://doi.org/10.7717/peerj.6312

The study of animal locomotion can be logistically challenging, especially in the case of large or unhandleable animals in uncontrolled environments. Here we demonstrate the utility of a low cost unmanned aerial vehicle (UAV) in measuring two-dimensi... Read More about The running kinematics of free-roaming giraffes, measured using a low cost unmanned aerial vehicle (UAV).

Parsimonious test of dynamic interaction (2019)
Journal Article
Chisholm, S., Stein, A. B., Jordan, N. R., Hubel, T. Y., Shawe-Taylor, J., Fearn, T., …Hailes, S. (2019). Parsimonious test of dynamic interaction. Ecology and Evolution, https://doi.org/10.1002/ece3.4805

In recent years, there have been significant advances in the technology used to collect data on the movement and activity patterns of humans and animals. GPS units, which form the primary source of location data, have become cheaper, more accurate, l... Read More about Parsimonious test of dynamic interaction.

Isolation and generation of osteoblasts (2019)
Book Chapter
Perpetuo, I. P., Bourne, L. E., & Orriss, I. R. (2019). Isolation and generation of osteoblasts. In Bone Research Protocols. New York: Humana Press. https://doi.org/10.1007/978-1-4939-8997-3_2

This chapter describes the isolation, culture, and staining of osteoblasts. The key advantages of this assay are that it allows direct measurement of bone matrix deposition and mineralization, as well as yielding good quantities of osteoblasts at def... Read More about Isolation and generation of osteoblasts.

Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment (2019)
Journal Article
Betts, C. A., McClorey, G., Healicon, R., Hammond, S. M., Manzano, R., Muses, S., …Wood, M. J. (2019). Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment. Human Molecular Genetics, 28(3), 396-406. https://doi.org/10.1093/hmg/ddy346

Duchenne muscular dystrophy (DMD) is caused by loss of dystrophin protein, leading to progressive muscle weakness and premature death due to respiratory and/or cardiac complications. Cardiac involvement is characterized by progressive dilated cardiom... Read More about Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment.

Morphological diversification of biomechanical traits: mustelid locomotor specializations and the macroevolution of long bone cross-sectional morphology (2019)
Journal Article
Kilbourne, B. M., & Hutchinson, J. R. (2019). Morphological diversification of biomechanical traits: mustelid locomotor specializations and the macroevolution of long bone cross-sectional morphology. BMC Evolutionary Biology, 19, 37. https://doi.org/10.1186/s12862-019-1349-8

Sost haploinsufficiency provokes peracute lethal cardiac tamponade without rescuing the osteopenia in a mouse model of excess glucocorticoids (2019)
Journal Article
Javaheri, B., Herbert, E., Hopkinson, M., Al-Jazzar, A., & Pitsillides, A. A. (2019). Sost haploinsufficiency provokes peracute lethal cardiac tamponade without rescuing the osteopenia in a mouse model of excess glucocorticoids. American Journal of Pathology, 189(4), 753-761. https://doi.org/10.1016/j.ajpath.2018.12.007

Glucocorticoid-induced secondary osteoporosis is the most predictable side-effect of this anti-inflammatory. One of the main mechanisms by which glucocorticoids achieve such deleterious outcome in bone is by antagonizing Wnt/β-catenin signalling. Scl... Read More about Sost haploinsufficiency provokes peracute lethal cardiac tamponade without rescuing the osteopenia in a mouse model of excess glucocorticoids.

Reverse-engineering the locomotion of a stem amniote (2019)
Journal Article
Nyakatura, J. A., Melo, K., Horvat, T., Karakasiliotis, K., Allen, V. R., Andikfar, A., …Ijspeert, A. J. (2019). Reverse-engineering the locomotion of a stem amniote. Nature, 565, 351-355. https://doi.org/10.1038/s41586-018-0851-2

Reconstructing the locomotion of extinct vertebrates offers insights into their palaeobiology and helps to conceptualize major transitions in vertebrate evolution. However, estimating the locomotor behaviour of a fossil species remains a challenge be... Read More about Reverse-engineering the locomotion of a stem amniote.

Non-invasive mechanical joint loading as an alternative model for osteoarthritic pain (2019)
Journal Article
Ter Heegde, F., Luiz, A. P., Santana-Varela, S., Chessell, I. P., Welsh, F., Wood, J. N., & Chenu, C. (2019). Non-invasive mechanical joint loading as an alternative model for osteoarthritic pain. https://doi.org/10.1002/art.40835

New insights into the morphology of the Carboniferous tetrapod Crassigyrinus scoticus from computed tomography (2019)
Journal Article
Herbst, E. C., & Hutchinson, J. R. (2019). New insights into the morphology of the Carboniferous tetrapod Crassigyrinus scoticus from computed tomography. Earth and Environmental Science Transactions of the Royal Society of Edinburgh, https://doi.org/10.1017/S1755691018000804

Medetomidine–ketamine–sevoflurane anaesthesia in juvenile Nile crocodiles (Crocodylus niloticus) undergoing experimental surgery (2019)
Journal Article
Monticelli, P., Ronaldson, H. L., Hutchinson, J. R., Cuff, A. R., D'Ovidio, D., & Adami, C. (2019). Medetomidine–ketamine–sevoflurane anaesthesia in juvenile Nile crocodiles (Crocodylus niloticus) undergoing experimental surgery. Veterinary Anaesthesia and Analgesia, 46(1), 84-89. https://doi.org/10.1016/j.vaa.2018.09.004

The locomotor kinematics and ground reaction forces of walking giraffes. (2019)
Journal Article
Basu, C. K., Wilson, A. M., & Hutchinson, J. R. (2019). The locomotor kinematics and ground reaction forces of walking giraffes. Journal of Experimental Biology, 222(22), https://doi.org/10.1242/jeb.159277

Giraffes (Giraffa camelopardalis Linnaeus 1758) possess specialised anatomy. Their disproportionately elongate limbs and neck confer recognised feeding advantages, but little is known about how their morphology affects locomotor function. In this stu... Read More about The locomotor kinematics and ground reaction forces of walking giraffes..

An Overview on Principles for Energy Efficient Robot Locomotion (2018)
Journal Article
Kashiri, N., Abate, A., Abram, S. J., Albu-Schaffer, A., Clary, P. J., Daley, M. A., …Tsagarakis, N. (2018). An Overview on Principles for Energy Efficient Robot Locomotion. Frontiers in Robotics and AI, 5(129), https://doi.org/10.3389/frobt.2018.00129

Despite enhancements in the development of robotic systems, the energy economy of today's robots lags far behind that of biological systems. This is in particular critical for untethered legged robot locomotion. To elucidate the current stage of ener... Read More about An Overview on Principles for Energy Efficient Robot Locomotion.

Cancellous bone and theropod dinosaur locomotion. Part I—an examination of cancellous bone architecture in the hindlimb bones of theropods (2018)
Journal Article
Bishop, P. J., Hocknull, S. A., Clemente, C. J., Hutchinson, J. R., Farke, A. A., Beck, B. R., …Lloyd, D. G. (2018). Cancellous bone and theropod dinosaur locomotion. Part I—an examination of cancellous bone architecture in the hindlimb bones of theropods. PeerJ, 6, e5778. https://doi.org/10.7717/peerj.5778

This paper is the first of a three-part series that investigates the architecture of cancellous (‘spongy’) bone in the main hindlimb bones of theropod dinosaurs, and uses cancellous bone architectural patterns to infer locomotor biomechanics in extin... Read More about Cancellous bone and theropod dinosaur locomotion. Part I—an examination of cancellous bone architecture in the hindlimb bones of theropods.

Targeted inhibition of aggrecanases prevents articular cartilage degradation and augments bone mass in the STR/Ort spontaneous model of osteoarthritis (2018)
Journal Article
Kanakis, I., Liu, K., Poulet, B., Javaheri, B., Van‘t Hof, R. J., Pitsillides, A. A., & Bou-Gharios, G. (2018). Targeted inhibition of aggrecanases prevents articular cartilage degradation and augments bone mass in the STR/Ort spontaneous model of osteoarthritis. https://doi.org/10.1002/art.40765

Cancellous bone and theropod dinosaur locomotion. Part II—a new approach to inferring posture and locomotor biomechanics in extinct tetrapod vertebrates (2018)
Journal Article
Bishop, P. J., Hocknull, S. A., Clemente, C. J., Hutchinson, J. R., Barrett, R. S., & Lloyd, D. G. (2018). Cancellous bone and theropod dinosaur locomotion. Part II—a new approach to inferring posture and locomotor biomechanics in extinct tetrapod vertebrates. PeerJ, 6, e5779. https://doi.org/10.7717/peerj.5779

This paper is the second of a three-part series that investigates the architecture of cancellous bone in the main hindlimb bones of theropod dinosaurs, and uses cancellous bone architectural patterns to infer locomotor biomechanics in extinct non-avi... Read More about Cancellous bone and theropod dinosaur locomotion. Part II—a new approach to inferring posture and locomotor biomechanics in extinct tetrapod vertebrates.

Cancellous bone and theropod dinosaur locomotion. Part III—Inferring posture and locomotor biomechanics in extinct theropods, and its evolution on the line to birds (2018)
Journal Article
Bishop, P. J., Hocknull, S. A., Clemente, C. J., Hutchinson, J. R., Farke, A. A., Beck, B. R., …Lloyd, D. G. (2018). Cancellous bone and theropod dinosaur locomotion. Part III—Inferring posture and locomotor biomechanics in extinct theropods, and its evolution on the line to birds. PeerJ, 6, e5777. https://doi.org/10.7717/peerj.5777

This paper is the last of a three-part series that investigates the architecture of cancellous bone in the main hindlimb bones of theropod dinosaurs, and uses cancellous bone architectural patterns to infer locomotor biomechanics in extinct non-avian... Read More about Cancellous bone and theropod dinosaur locomotion. Part III—Inferring posture and locomotor biomechanics in extinct theropods, and its evolution on the line to birds.

Remarkable muscles, remarkable locomotion in desert-dwelling wildebeest (2018)
Journal Article
Curtin, N. A., Bartlam-Brooks, H. L. A., Hubel, T. Y., Lowe, J. C., Gardner-Medwin, A. R., Bennitt, M., …Wilson, A. M. (2018). Remarkable muscles, remarkable locomotion in desert-dwelling wildebeest. Nature, https://doi.org/10.1038/s41586-018-0602-4

Large mammals that live in arid and/or desert environments can cope with seasonal and local variations in rainfall, food and climate1 by moving long distances, often without reliable water or food en route. The capacity of an animal for this long-dis... Read More about Remarkable muscles, remarkable locomotion in desert-dwelling wildebeest.