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Single-transcript multiplex in situ hybridisation reveals unique patterns of dystrophin isoform expression in the developing mammalian embryo (2020)
Journal Article
Hildyard, J. C. W., Crawford, A. H., Rawson, F., Riddell, D. O., Harron, R. C. M., & Piercy, R. J. (2020). Single-transcript multiplex in situ hybridisation reveals unique patterns of dystrophin isoform expression in the developing mammalian embryo. Wellcome Open Research, 5, 76. https://doi.org/10.12688/wellcomeopenres.15762.2

Background: The dystrophin gene has multiple isoforms: full-length dystrophin (dp427) is principally known for its expression in skeletal and cardiac muscle, but is also expressed in the brain, and several internal promoters give rise to shorter, N-t... Read More about Single-transcript multiplex in situ hybridisation reveals unique patterns of dystrophin isoform expression in the developing mammalian embryo.

Detection of hypoglycin A and MCPA‐carnitine in equine serum and muscle tissue: optimisation and validation of a LC‐MS based method without derivatisation (2020)
Journal Article
González Medina, S., Hyde, C., Lovera, I., & Piercy, R. J. (2020). Detection of hypoglycin A and MCPA‐carnitine in equine serum and muscle tissue: optimisation and validation of a LC‐MS based method without derivatisation. Equine Veterinary Journal, https://doi.org/10.1111/evj.13303

Measurement of hypoglycin A (HGA) and its toxic metabolite, methylenecyclopropylacetic acid (MCPA), in equine serum confirms a diagnosis of atypical myopathy (AM), a pasture‐associated toxic rhabdomyolysis with high mortality linked to the ingestion... Read More about Detection of hypoglycin A and MCPA‐carnitine in equine serum and muscle tissue: optimisation and validation of a LC‐MS based method without derivatisation.

Investigation into pathophysiology of naturally occurring palatal instability and intermittent dorsal displacement of the soft palate (DDSP) in racehorses: Thyro-hyoid muscles fatigue during exercise (2019)
Journal Article
Cercone, M., Olsen, E., Perkins, J. D. M., Cheetham, J., Mitchell, L. M., & Ducharme, N. G. (2019). Investigation into pathophysiology of naturally occurring palatal instability and intermittent dorsal displacement of the soft palate (DDSP) in racehorses: Thyro-hyoid muscles fatigue during exercise. PLoS ONE, 14, https://doi.org/10.1371/journal.pone.0224524

Exercise induced intermittent dorsal displacement of the soft palate (DDSP) is a common cause of airway obstruction and poor performance in racehorses. The definite etiology is still unclear, but through an experimental model, a role in the developme... Read More about Investigation into pathophysiology of naturally occurring palatal instability and intermittent dorsal displacement of the soft palate (DDSP) in racehorses: Thyro-hyoid muscles fatigue during exercise.

Evaluation of the Effects of Synovial Multipotent Cells on Deep Digital Flexor Tendon Repair in a Large Animal Model of Intra-Synovial Tendinopathy (2019)
Journal Article
Khan, M. R., Smith, R. K., David, F. H., Lam, R., Hughes, G., DeGodoy, R., …Dudhia, J. (2019). Evaluation of the Effects of Synovial Multipotent Cells on Deep Digital Flexor Tendon Repair in a Large Animal Model of Intra-Synovial Tendinopathy. Journal of Orthopaedic Research, 38(1), 128-138. https://doi.org/10.1002/jor.24423

ntra‐synovial tendon injuries are a common orthopedic problem with limited treatment options. The synovium is a specialized connective tissue forming the inner encapsulating lining of diarthrodial joints and intra‐synovial tendons. It contains multip... Read More about Evaluation of the Effects of Synovial Multipotent Cells on Deep Digital Flexor Tendon Repair in a Large Animal Model of Intra-Synovial Tendinopathy.

Equine odontogenic tumors: Clinical presentation, CT findings, and outcome in 11 horses (2019)
Journal Article
Morgan, R. E., Fiske-Jackson, A. R., Hellige, M., Gerhauser, I., Wohlsein, P., & Biggi, M. (2019). Equine odontogenic tumors: Clinical presentation, CT findings, and outcome in 11 horses. https://doi.org/10.1111/vru.12793

Odontogenic tumors present as locally invasive, slow growing, firm swellings on the face. They are rare in all species and are characterized histologically by the degree of differentiation and dental tissue of origin. Radiographic appearance is not p... Read More about Equine odontogenic tumors: Clinical presentation, CT findings, and outcome in 11 horses.

The Effect of Training on Stride Duration in a Cohort of Two-Year-Old and Three-Year-Old Thoroughbred Racehorses (2019)
Journal Article
Parkes, R. S. V., Weller, R., Pfau, T., & Witte, T. H. (2019). The Effect of Training on Stride Duration in a Cohort of Two-Year-Old and Three-Year-Old Thoroughbred Racehorses. Animals, 9(7), 466. https://doi.org/10.3390/ani9070466

Objective gait monitoring is increasingly accessible to trainers. A more comprehensive understanding of ‘normal’ gait adaptations is required. Forty two-year-old thoroughbred racehorses were recruited when entering training and followed for 22 months... Read More about The Effect of Training on Stride Duration in a Cohort of Two-Year-Old and Three-Year-Old Thoroughbred Racehorses.

The influence of gap size on the development of fracture union with a micro external fixator (2019)
Journal Article
Meeson, R. L., Moazen, M., Sanghani-Keri, A., Osagie-Clouard, L., Coathup, M., & Blunn, G. (2019). The influence of gap size on the development of fracture union with a micro external fixator. Journal of the Mechanical Behavior of Biomedical Materials, 99, 161-168. https://doi.org/10.1016/j.jmbbm.2019.07.015

Increasingly, the rat femoral fracture model is being used for preclinical investigations of fracture healing, however, the effect of gap size and its influence on mechanobiology is not well understood. We aimed to evaluate the influence of osteotomy... Read More about The influence of gap size on the development of fracture union with a micro external fixator.

Spontaneous dog osteoarthritis — a One Medicine vision (2019)
Journal Article
Meeson, R. L., Todhunter, R. J., Blunn, G., Nuki, G., & Pitsillides, A. A. (2019). Spontaneous dog osteoarthritis — a One Medicine vision. Nature Reviews Rheumatology, 15(5), 273-287. https://doi.org/10.1038/s41584-019-0202-1

Osteoarthritis (OA) is a global disease that, despite extensive research, has limited treatment options. Pet dogs share both an environment and lifestyle attributes with their owners, and a growing awareness is developing in the public and among rese... Read More about Spontaneous dog osteoarthritis — a One Medicine vision.

Relating neuromuscular control to functional anatomy of limb muscles in extant archosaurs (2019)
Journal Article
Cuff, A. R., Daley, M. A., Michel, K. B., Allen, V. R., Lamas, L. P., Adami, C., …Hutchinson, J. R. (2019). Relating neuromuscular control to functional anatomy of limb muscles in extant archosaurs. Journal of Morphology, 280(5), 666-680. https://doi.org/10.1002/jmor.20973

Electromyography (EMG) is used to understand muscle activity patterns in animals. Understanding how much variation exists in muscle activity patterns in homologous muscles across animal clades during similar behaviours is important for evaluating the... Read More about Relating neuromuscular control to functional anatomy of limb muscles in extant archosaurs.

Pituitary gland abscess in a horse subsequent to head trauma (2019)
Journal Article
Morgan, R. E., Fiske-Jackson, A. R., & Biggi, M. (2019). Pituitary gland abscess in a horse subsequent to head trauma. Equine Veterinary Education, https://doi.org/10.1111/eve.13043

A 5‐year‐old Thoroughbred gelding with recent history of head trauma presented with multiple facial swellings, bilateral mucopurulent nasal discharge, neck pain, inappetence and depression. On computed tomographic examination, lesions within the pitu... Read More about Pituitary gland abscess in a horse subsequent to head trauma.

Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy (2018)
Journal Article
Amoasii, L., Hildyard, J. C. W., Li, H., Sanchez-Ortiz, E., Mireault, A., Caballero, D., …Olson, E. N. (2018). Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy. Science, 362(6410), 86-91. https://doi.org/10.1126/science.aau1549

Mutations in the gene encoding dystrophin, a protein that maintains muscle integrity and function, cause Duchenne muscular dystrophy (DMD). The deltaE50-MD dog model of DMD harbors a mutation corresponding to a mutational “hotspot” in the human DMD g... Read More about Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy.

The scaling or ontogeny of human gait kinetics and walk-run transition: The implications of work vs. peak power minimization (2018)
Journal Article
Usherwood, J. R., Hubel, T. Y., Smith, B. J. H., Self Davies, Z. T., & Sobota, G. (2018). The scaling or ontogeny of human gait kinetics and walk-run transition: The implications of work vs. peak power minimization. Journal of Biomechanics, 81, 12-21. https://doi.org/10.1016/j.jbiomech.2018.09.004

A simple model is developed to find vertical force profiles and stance durations that minimize either limb mechanical work or peak power demands during bipedal locomotion. The model predicts that work minimization is achieved with a symmetrical verti... Read More about The scaling or ontogeny of human gait kinetics and walk-run transition: The implications of work vs. peak power minimization.

Alterations in body lean angle in lame horses before and after diagnostic analgesia in straight lines in hand and on the lunge (2018)
Journal Article
Greve, L., Pfau, T., & Dyson, S. (2018). Alterations in body lean angle in lame horses before and after diagnostic analgesia in straight lines in hand and on the lunge. https://doi.org/10.1016/j.tvjl.2018.07.006

Altered body lean has been subjectively observed during lungeing in lame horses. The objectives were to quantify the influence of lameness on body lean in trot on the lunge and to investigate the influence of improvement in lameness on the difference... Read More about Alterations in body lean angle in lame horses before and after diagnostic analgesia in straight lines in hand and on the lunge.

Detection of equine atypical myopathy-associated hypoglycin A in plant material: Optimisation and validation of a novel LC-MS based method without derivatisation (2018)
Journal Article
González-Medina, S., Hyde, C., Lovera, I., & Piercy, R. J. (2018). Detection of equine atypical myopathy-associated hypoglycin A in plant material: Optimisation and validation of a novel LC-MS based method without derivatisation. PLoS ONE, 13(7), e0199521. https://doi.org/10.1371/journal.pone.0199521

Hypoglycin A (HGA) toxicity, following ingestion of material from certain plants, is linked to an acquired multiple acyl-CoA dehydrogenase deficiency known as atypical myopathy, a commonly fatal form of equine rhabdomyolysis seen worldwide. Whilst so... Read More about Detection of equine atypical myopathy-associated hypoglycin A in plant material: Optimisation and validation of a novel LC-MS based method without derivatisation.