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Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice (2019)
Journal Article
Ying Wu, , Chang, Y. M., Stell, A. J., Priestnall, S. L., Sharma, E., Goulart, M. R., …Garden, O. A. (2019). Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice. https://doi.org/10.1038/s41598-019-50065-8

Regulatory T cells (Tregs) are a double-edged regulator of the immune system. Aberrations of Tregs correlate with pathogenesis of inflammatory, autoimmune and neoplastic disorders. Phenotypically and functionally distinct subsets of Tregs have been i... Read More about Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice.

PinR mediates the generation of reversible population diversity in Streptococcus zooepidemicus (2015)
Journal Article
Steward, K. F., Harrison, T., Robinson, C., Slater, J. D., Maskell, D. J., Harris, S. R., …Waller, A. S. (2015). PinR mediates the generation of reversible population diversity in Streptococcus zooepidemicus. Microbiology, 161, 1105-1112. https://doi.org/10.1099/mic.0.000057

Opportunistic pathogens must adapt to and survive in a wide range of complex ecosystems. Streptococcus zooepidemicus is an opportunistic pathogen of horses and many other animals, including humans. The assembly of different surface architecture pheno... Read More about PinR mediates the generation of reversible population diversity in Streptococcus zooepidemicus.

Monoacylated Cellular Prion Proteins Reduce Amyloid-beta-Induced Activation of Cytoplasmic Phospholipase A2 and Synapse Damage
Journal Article
West, E., Osborne, C., Nolan, W., & Bate, C. (in press). Monoacylated Cellular Prion Proteins Reduce Amyloid-beta-Induced Activation of Cytoplasmic Phospholipase A2 and Synapse Damage. Biology, 4(2), 367-82. https://doi.org/10.3390/biology4020367

Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by the accumulation of amyloid-β (Aβ) and the loss of synapses. Aggregation of the cellular prion protein (PrPC) by Aβ oligomers induced synapse damage in cultured neur... Read More about Monoacylated Cellular Prion Proteins Reduce Amyloid-beta-Induced Activation of Cytoplasmic Phospholipase A2 and Synapse Damage.

Mutation of the maturase lipoprotein attenuates the virulence of Streptococcus equi to a greater extent than does loss of general lipoprotein lipidation
Journal Article
Hamilton, A., Robinson, C., Sutcliffe, I. C., Slater, J. D., Maskell, D. J., Davis-Poynter, N. J., …Harrington, D. J. Mutation of the maturase lipoprotein attenuates the virulence of Streptococcus equi to a greater extent than does loss of general lipoprotein lipidation. Infection and Immunity, 74(12), 6907-6919. https://doi.org/10.1128/IAI.01116-06