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The cholesterol ester cycle regulates signalling complexes and synapse damage caused by amyloid-ß (2017)
Journal Article
West, E., Osborne, C., & Bate, C. (2017). The cholesterol ester cycle regulates signalling complexes and synapse damage caused by amyloid-ß. Journal of Cell Science, 130, 3050-3059. https://doi.org/10.1242/jcs.205484

Cholesterol is required for the formation and function of some signalling platforms. In synaptosomes, amyloid-β (Aβ) oligomers, the causative agent in Alzheimer's disease, bind to cellular prion proteins (PrPC) resulting in increased cholesterol conc... Read More about The cholesterol ester cycle regulates signalling complexes and synapse damage caused by amyloid-ß.

Sialylated glycosylphosphatidylinositols suppress the production of toxic amyloid-ß oligomers (2017)
Journal Article
Nolan, W., McHale-Owen, H., & Bate, C. (2017). Sialylated glycosylphosphatidylinositols suppress the production of toxic amyloid-ß oligomers. Biochemical Journal, 474(17), 3045-3058. https://doi.org/10.1042/BCJ20170239

The production of amyloid-β (Aβ) is a key factor driving pathogenesis in Alzheimer's disease (AD). Increasing concentrations of soluble Aβ oligomers within the brain lead to synapse degeneration and the progressive dementia characteristic of AD. Sinc... Read More about Sialylated glycosylphosphatidylinositols suppress the production of toxic amyloid-ß oligomers.

Epidemiological Risk Factors for Animal Influenza A Viruses Overcoming Species Barriers (2017)
Journal Article
Harris, K. A., Freidl, G. S., Munoz, O. S., Von Dobschuetz, S., De Nardi, M., Wieland, B., …FLURISK Consortium, . (2017). Epidemiological Risk Factors for Animal Influenza A Viruses Overcoming Species Barriers. EcoHealth, 14(2), 342-360. https://doi.org/10.1007/s10393-017-1244-y

Drivers and risk factors for Influenza A virus transmission across species barriers are poorly understood, despite the ever present threat to human and animal health potentially on a pandemic scale. Here we review the published evidence for epidemiol... Read More about Epidemiological Risk Factors for Animal Influenza A Viruses Overcoming Species Barriers.

Are Eimeria Genetically Diverse, and Does It Matter? (2017)
Journal Article
Clark, E. L., Tomley, F. M., & Blake, D. P. (2017). Are Eimeria Genetically Diverse, and Does It Matter?. Trends in Parasitology, 33(3), 231-241. https://doi.org/10.1016/j.pt.2016.08.007

Eimeria pose a risk to all livestock species as a cause of coccidiosis, reducing productivity and compromising animal welfare. Pressure to reduce drug use in the food chain makes the development of cost-effective vaccines against Eimeria essential. F... Read More about Are Eimeria Genetically Diverse, and Does It Matter?.