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Are Eimeria Genetically Diverse, and Does It Matter? (2017)
Journal Article
Clark, E. L., Tomley, F. M., & Blake, D. P. (2017). Are Eimeria Genetically Diverse, and Does It Matter?. Trends in Parasitology, 33(3), 231-241. https://doi.org/10.1016/j.pt.2016.08.007

Eimeria pose a risk to all livestock species as a cause of coccidiosis, reducing productivity and compromising animal welfare. Pressure to reduce drug use in the food chain makes the development of cost-effective vaccines against Eimeria essential. F... Read More about Are Eimeria Genetically Diverse, and Does It Matter?.

Sialic Acid within the Glycosylphosphatidylinositol Anchor Targets the Cellular Prion Protein to Synapses (2016)
Journal Article
Bate, C., Nolan, W., McHale-Owen, H., & Williams, A. (2016). Sialic Acid within the Glycosylphosphatidylinositol Anchor Targets the Cellular Prion Protein to Synapses. Journal of Biological Chemistry, 291(33), 17093-101. https://doi.org/10.1074/jbc.M116.731117

Although the cellular prion protein (PrPC) is concentrated at synapses, the factors that target PrPC to synapses are not understood. Here we demonstrate that exogenous PrPC was rapidly targeted to synapses in recipient neurons derived from Prnp knock... Read More about Sialic Acid within the Glycosylphosphatidylinositol Anchor Targets the Cellular Prion Protein to Synapses.

The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis (2016)
Journal Article
Ho, N. A. T., Dawes, S. S., Crowe, A. M., Casabon, I., Gao, C., Kendall, S. L., …Lott, J. S. (2016). The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis. Journal of Biological Chemistry, 291(14), 7256-7266. https://doi.org/10.1074/jbc.M115.707760

Cholesterol can be a major carbon source for Mycobacterium tuberculosis during infection, both at an early stage in the macrophage phagosome and later within the necrotic granuloma. KstR is a highly conserved TetR family transcriptional repressor tha... Read More about The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis.

Whole genome resequencing of the human parasite Schistosoma mansoni reveals population history and effects of selection (2016)
Journal Article
Crellen, T., Allan, F., David, S., Durrant, C., Huckvale, T., Holroyd, N., …Cotton, J. A. (2016). Whole genome resequencing of the human parasite Schistosoma mansoni reveals population history and effects of selection. https://doi.org/10.1038/srep20954

Schistosoma mansoni is a parasitic fluke that infects millions of people in the developing world. This study presents the first application of population genomics to S. mansoni based on high-coverage resequencing data from 10 global isolates and an i... Read More about Whole genome resequencing of the human parasite Schistosoma mansoni reveals population history and effects of selection.

An in vitro model for synaptic loss in neurodegenerative diseases suggests a neuroprotective role for valproic acid via inhibition of cPLA(2) dependent signalling (2016)
Journal Article
Williams, R. S. B., & Bate, C. (2016). An in vitro model for synaptic loss in neurodegenerative diseases suggests a neuroprotective role for valproic acid via inhibition of cPLA(2) dependent signalling. Neuropharmacology, 101, 566-575. https://doi.org/10.1016/j.neuropharm.2015.06.013

Many neurodegenerative diseases present the loss of synapses as a common pathological feature. Here we have employed an in vitro model for synaptic loss to investigate the molecular mechanism of a therapeutic treatment, valproic acid (VPA). We show t... Read More about An in vitro model for synaptic loss in neurodegenerative diseases suggests a neuroprotective role for valproic acid via inhibition of cPLA(2) dependent signalling.

Sialic Acid on the Glycosylphosphatidylinositol Anchor Regulates PrP-mediated Cell Signaling and Prion Formation (2016)
Journal Article
Bate, C., Nolan, W., McHale-Owen, H., & Williams, A. (2016). Sialic Acid on the Glycosylphosphatidylinositol Anchor Regulates PrP-mediated Cell Signaling and Prion Formation. Journal of Biological Chemistry, 291(33), 17093-17101. https://doi.org/10.1074/jbc.M116.731117

The prion diseases occur following the conversion of the cellular prion protein (PrPC) into disease-related isoforms (PrPSc). In this study, the role of the glycosylphosphatidylinositol (GPI) anchor attached to PrPC in prion formation was examined us... Read More about Sialic Acid on the Glycosylphosphatidylinositol Anchor Regulates PrP-mediated Cell Signaling and Prion Formation.

Detection and molecular characterisation of Cryptosporidium parvum in British European hedgehogs (Erinaceus europaeus) (2015)
Journal Article
Sangster, L., Blake, D. P., Robinson, G., Hopkins, T. C., Sa, R. C. C., Cunningham, A. A., …Lawson, B. (2015). Detection and molecular characterisation of Cryptosporidium parvum in British European hedgehogs (Erinaceus europaeus). Veterinary Parasitology, 217, 39-44. https://doi.org/10.1016/j.vetpar.2015.12.006

Surveillance was conducted for the occurrence of protozoan parasites of the genus Cryptosporidium in European hedgehogs (Erinaceus europaeus) in Great Britain. In total, 108 voided faecal samples were collected from hedgehogs newly admitted to eight... Read More about Detection and molecular characterisation of Cryptosporidium parvum in British European hedgehogs (Erinaceus europaeus).

Population, genetic, and antigenic diversity of the apicomplexan Eimeria tenella and their relevance to vaccine development (2015)
Journal Article
Blake, D. P., Clark, E. L., Macdonald, S. E., Thenmozhi, V., Kundu, K., Garg, R., …Tomley, F. M. (2015). Population, genetic, and antigenic diversity of the apicomplexan Eimeria tenella and their relevance to vaccine development. https://doi.org/10.1073/pnas.1506468112

The phylum Apicomplexa includes serious pathogens of humans and animals. Understanding the distribution and population structure of these protozoan parasites is of fundamental importance to explain disease epidemiology and develop sustainable control... Read More about Population, genetic, and antigenic diversity of the apicomplexan Eimeria tenella and their relevance to vaccine development.

PinR mediates the generation of reversible population diversity in Streptococcus zooepidemicus (2015)
Journal Article
Steward, K. F., Harrison, T., Robinson, C., Slater, J. D., Maskell, D. J., Harris, S. R., …Waller, A. S. (2015). PinR mediates the generation of reversible population diversity in Streptococcus zooepidemicus. Microbiology, 161, 1105-1112. https://doi.org/10.1099/mic.0.000057

Opportunistic pathogens must adapt to and survive in a wide range of complex ecosystems. Streptococcus zooepidemicus is an opportunistic pathogen of horses and many other animals, including humans. The assembly of different surface architecture pheno... Read More about PinR mediates the generation of reversible population diversity in Streptococcus zooepidemicus.

Evidence for human norovirus infection of dogs in the UK (2015)
Journal Article
Caddy, S. L., De Rougemont, A., Emmott, E., El-Attar, L. M. R., Mitchell, J. A., Hollinshead, M., …Goodfellow, I. (2015). Evidence for human norovirus infection of dogs in the UK. Journal of Clinical Microbiology, 53(6), 1873-1883. https://doi.org/10.1128/JCM.02778-14

Human noroviruses (HuNoVs) are a major cause of viral gastroenteritis, with an estimated 3 million cases per year in the United Kingdom. HuNoVs have recently been isolated from pet dogs in Europe (M. Summa, C.-H. von Bonsdorff, and L. Maunula, J Clin... Read More about Evidence for human norovirus infection of dogs in the UK.