Glimepiride Reduces the Expression of PrPC, Prevents PrPSc Formation and Protects against Prion Mediated Neurotoxicity
Journal Article
Bate, C., Tayebi, M., Diomede, L., Salmona, M., & Williams, A. Glimepiride Reduces the Expression of PrPC, Prevents PrPSc Formation and Protects against Prion Mediated Neurotoxicity. PLoS ONE, 4(12), e8221. https://doi.org/10.1371/journal.pone.0008221
Complete NMR assignments for the second microneme adhesive repeat (MAR) domain from Eimeria tenella microneme protein EtMIC3
Journal Article
Lai, L., Simpson, P., Burnstead, J., Tomley, F. M., & Matthews, S. Complete NMR assignments for the second microneme adhesive repeat (MAR) domain from Eimeria tenella microneme protein EtMIC3. Biomolecular NMR Assignments, 3(2), 175-7. https://doi.org/10.1007/s12104-009-9168-2
Proteomic comparison of four Eimeria tenella life-cycle stages: unsporulated oocyst, sporulated oocyst, sporozoite and second-generation merozoite
Journal Article
Lal, K., Bromley, E., Oakes, R. D., Prieto, J. H., Sanderson, S. J., Kurian, D., …Tomley, F. M. Proteomic comparison of four Eimeria tenella life-cycle stages: unsporulated oocyst, sporulated oocyst, sporozoite and second-generation merozoite. Proteomics, 9(19), 4566-76. https://doi.org/10.1002/pmic.200900305
Plasmodium male development gene-1 (mdv-1) is important for female sexual development and identifies a polarised plasma membrane during zygote development
Journal Article
Lal, K., Delves, M. J., Bromley, E., Wastling, J. M., Tomley, F. M., & Sinden, R. E. Plasmodium male development gene-1 (mdv-1) is important for female sexual development and identifies a polarised plasma membrane during zygote development. International Journal for Parasitology, 39(7), 755-61. https://doi.org/10.1016/j.ijpara.2008.11.008
Characterisation of Plasmodium invasive organelles; an ookinete microneme proteome
Journal Article
Lal, K., Prieto, J. H., Bromley, E., Sanderson, S. J., Yates, J. R. 3., Wastling, J. M., …Sinden, R. E. Characterisation of Plasmodium invasive organelles; an ookinete microneme proteome. Proteomics, 9(5), 1142-51. https://doi.org/10.1002/pmic.200800404
CD8+ T-cell responses to Theileria parva are preferentially directed to a single dominant antigen: Implications for parasite strain-specific immunity
Journal Article
MacHugh, N. D., Connelly, T., Graham, S. P., Pelle, R., Formisano, P., Taracha, E. L., …Morrison, W. CD8+ T-cell responses to Theileria parva are preferentially directed to a single dominant antigen: Implications for parasite strain-specific immunity. European Journal of Immunology, 39(9), 1-11. https://doi.org/10.1002/eji.200939227
Expression analysis of the Theileria parva subtelomere-encoded variable secreted protein gene family
Journal Article
Schmuckli-Maurer, J., Casanova, C., Schmied, S., Affentranger, S., Parvanova, I., Kang'A, S., …Dobbelaere, D. Expression analysis of the Theileria parva subtelomere-encoded variable secreted protein gene family. PLoS ONE, 4(3), e4839. https://doi.org/10.1371/journal.pone.0004839
Livestock infectious diseases and zoonoses
Journal Article
Tomley, F. M., & Shirley, M. W. Livestock infectious diseases and zoonoses. Philosophical Transactions of the Royal Society B: Biological Sciences, 364(1530), 2637-42. https://doi.org/10.1098/rstb.2009.0133
New putative virulence factors of Streptococcus suis involved in invasion of porcine brain microvascular endothelial cells
Journal Article
Vanier, G., Fittipaldi, N., Slater, J. D., Dominguez-Punaro, M. D., Rycroft, A. N., Segura, M., …Gottschalk, M. New putative virulence factors of Streptococcus suis involved in invasion of porcine brain microvascular endothelial cells. Microbial Pathogenesis, 46(1), 13-20. https://doi.org/10.1016/j.micpath.2008.10.003
LIPID RAFTS, CELL SIGNALLING, PRION FORMATION AND NEURODEGENERATION IN PRION DISEASES
Journal Article
Williams, A., & Bate, C. LIPID RAFTS, CELL SIGNALLING, PRION FORMATION AND NEURODEGENERATION IN PRION DISEASES. Journal of Neurochemistry, 108, 44-44
Stable transfection of Eimeria tenella: constitutive expression of the YFP-YFP molecule throughout the life cycle.
Journal Article
Yan, W., Liu, X., Shi, T., Hao, L., Tomley, F. M., & Suo, X. Stable transfection of Eimeria tenella: constitutive expression of the YFP-YFP molecule throughout the life cycle. International Journal for Parasitology, 39(1), 109-17. https://doi.org/10.1016/j.ijpara.2008.06.013
MORN1 has a conserved role in asexual and sexual development across the apicomplexa. Eukaryot Cell
Journal Article
Ferguson, D. J. P., Sahoo, N., Pinches, R. A., Bumstead, J. M., Tomley, F. M., & Gubbels, M. J. (in press). MORN1 has a conserved role in asexual and sexual development across the apicomplexa. Eukaryot Cell. https://doi.org/10.1128/EC.00021-08The gene encoding the membrane occupation and recognition nexus protein MORN1 is conserved across the Apicomplexa. In Toxoplasma gondii, MORN1 is associated with the spindle poles, the anterior and posterior rings of the inner membrane complex (IMC).... Read More about MORN1 has a conserved role in asexual and sexual development across the apicomplexa. Eukaryot Cell.
Genomic organisation and allelic diversity within coding and non-coding regions of the Ovar-DRB1 locus
Journal Article
Ballingall, K. T., Fardoe, K., & McKeever, D. J. Genomic organisation and allelic diversity within coding and non-coding regions of the Ovar-DRB1 locus. Immunogenetics, 60(2), 95-103. https://doi.org/10.1007/s00251-008-0278-2
Genetic and proteomic analysis of the MHC class I repertoire from four ovine haplotypes
Journal Article
Ballingall, K. T., Miltiadou, D., Chai, Z. W., McLean, K., Rocchi, M., Yaga, R., & McKeever, D. J. Genetic and proteomic analysis of the MHC class I repertoire from four ovine haplotypes. Immunogenetics, 60(3-4), 177-184. https://doi.org/10.1007/s00251-008-0276-4
Docosahexaenoic and eicosapentaenoic acids increase neuronal death in response to HuPrP82-146 and A beta 1-42
Journal Article
Bate, C., Marshall, V., Colombo, L., Diomede, L., Salmona, M., & Williams, A. Docosahexaenoic and eicosapentaenoic acids increase neuronal death in response to HuPrP82-146 and A beta 1-42. Neuropharmacology, 54(6), 934-943. https://doi.org/10.1016/j.neuropharm.2008.02.003Dietary supplements containing polyunsaturated fatty acids (PUFA) are frequently taken for their perceived health benefits including a possible reduction in cognitive decline in the elderly. Here we report that pre-treatment with docosahexaenoic acid... Read More about Docosahexaenoic and eicosapentaenoic acids increase neuronal death in response to HuPrP82-146 and A beta 1-42.
Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells
Journal Article
Bate, C., Tayebi, M., Diomede, L., Salmona, M., & Williams, A. Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells. BMC Biology, 6, https://doi.org/10.1186/1741-7007-6-39Background: The transmissible spongiform encephalopathies, otherwise known as prion diseases, occur following the conversion of the cellular prion protein (PrPC) to an alternatively folded, disease-associated isoform (PrPSc). Recent studies suggest t... Read More about Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells.
Cholesterol esterification reduces the neurotoxicity of prions
Journal Article
Bate, C., Tayebi, M., & Williams, A. Cholesterol esterification reduces the neurotoxicity of prions. Neuropharmacology, 54(8), 1247-1253. https://doi.org/10.1016/j.neuropharm.2008.04.002The transmissible spongiform encephalopathies develop following the conversion of a host-encoded protein (PrPC) into abnormally folded, disease-related isoforms (PrPSc). Here we report that three acylcoenzyme A:cholesterol acyltransferase (ACAT) inhi... Read More about Cholesterol esterification reduces the neurotoxicity of prions.
Ginkgolides protect against amyloid-beta(1-42)-mediated synapse damage in vitro
Journal Article
Bate, C., Tayebi, M., & Williams, A. Ginkgolides protect against amyloid-beta(1-42)-mediated synapse damage in vitro. Molecular Neurodegeneration, 3(1), https://doi.org/10.1186/1750-1326-3-1
Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A(2) activation
Journal Article
Bate, C., Tayebi, M., & Williams, A. Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A(2) activation. BMC Biology, 6, https://doi.org/10.1186/1741-7007-6-8Background: The transmissible spongiform encephalopathies (TSEs), otherwise known as the prion diseases, occur following the conversion of the normal cellular prion protein ( PrPC) to an alternatively folded isoform ( PrPSc). The accumulation of PrPS... Read More about Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A(2) activation.
Do prion-induced changes in cholesterol trigger neurodegeneration?
Journal Article
Bate, C., & Williams, A. Do prion-induced changes in cholesterol trigger neurodegeneration?. Future Neurology, 3(4), 367-370. https://doi.org/10.2217/14796708.3.4.367
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