A tunnel is not enough: Mice benefit from in-cage provision of a communal shelter as well as a handling tunnel (2021)
Journal Article
Burn, C., & Popat, R. (2021). A tunnel is not enough: Mice benefit from in-cage provision of a communal shelter as well as a handling tunnel. Animal Technology and Welfare, 20, 203-210

Mouse shelters can provide mice with security, help them thermoregulate, offer darkness to prevent damage to their eyes and enable climbing and gnawing opportunities. For laboratory mice, there is a vast array of commercially available cage furniture... Read More about A tunnel is not enough: Mice benefit from in-cage provision of a communal shelter as well as a handling tunnel.

Time to Loss of Behavioural and Brainstem Responses of Ducks Following Non-Stunned Slaughter (2021)
Journal Article
Gibson, T. (in press). Time to Loss of Behavioural and Brainstem Responses of Ducks Following Non-Stunned Slaughter. Animals, https://doi.org/10.3390/ani11123531

Non-stunned slaughter has been extensively described for other farmed species but there has been limited research on waterfowl. The study assessed 34 ducks in a non-stunned halal slaughter-house in Brazil for time to loss of consciousness using vario... Read More about Time to Loss of Behavioural and Brainstem Responses of Ducks Following Non-Stunned Slaughter.

On the importance of integrating comparative anatomy and One Health perspectives in anatomy education (2021)
Journal Article
Bhattacharjee, S., Davies, D. C., Mcgonnell, I. M., Holmes, J. M., Kilroy, D., Holland, J. C., & Reynolds, A. L. (2022). On the importance of integrating comparative anatomy and One Health perspectives in anatomy education. Journal of Anatomy, 240(3), 429-446. https://doi.org/10.1111/joa

As a result of many factors, including climate change, unrestricted population growth, widespread deforestation and intensive agriculture, a new pattern of diseases in humans is emerging. With increasing encroachment by human societies into wild doma... Read More about On the importance of integrating comparative anatomy and One Health perspectives in anatomy education.

In silico comparative analysis of LRRK2 interactomes from brain, kidney and lung (2021)
Journal Article
Verma, A., Ebanks, K., Fok, C., Lewis, P. A., Bettencourt, C., & Bandopadhyay, R. (2021). In silico comparative analysis of LRRK2 interactomes from brain, kidney and lung. Brain Research, 1765, 147503. https://doi.org/10.1016/j.brainres.2021.147503

Pandemic Puppies: Characterising motivations and behaviours of UK owners who purchased puppies during the 2020 COVID-19 Pandemic (2021)
Journal Article
Packer, R., Brand, C., Belshaw, Z., Pegram, C., Stevens, K., & O'Neill, D. (2021). Pandemic Puppies: Characterising motivations and behaviours of UK owners who purchased puppies during the 2020 COVID-19 Pandemic. Animals, 11(9), 2500. https://doi.org/10.3390/ani11092500

Attempts to control the spread of coronavirus during the COVID-19 Pandemic included periods of ‘lockdown’ in the UK, where many households spent several months at home with limited external social contact. Data from diverse sources suggest unusually... Read More about Pandemic Puppies: Characterising motivations and behaviours of UK owners who purchased puppies during the 2020 COVID-19 Pandemic.

Abrogation of LRRK2 dependent Rab10 phosphorylation with TLR4 activation and alterations in evoked cytokine release in immune cells (2021)
Journal Article
Nazish, I., Arber, C., Piers, T. M., Warner, T. T., Hardy, J. A., Lewis, P. A., …Bandopadhyay, R. (2021). Abrogation of LRRK2 dependent Rab10 phosphorylation with TLR4 activation and alterations in evoked cytokine release in immune cells. Neurochemistry International, 147, 105070. https://doi.org/10.1016/j.neuint.2021.105070

An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein (2021)
Journal Article
Kara, E., Crimi, A., Wiedmer, A., Emmenegger, M., Manzoni, C., Bandres-Ciga, S., …Aguzzi, A. (2021). An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein. Cell Reports, 35(10), 109189. https://doi.org/10.1016/j.celrep.2021.109189

The pen is milder than the blade: Identification marking mice using ink on the tail appears more humane than ear-punching even with local anaesthetic (2021)
Journal Article
Burn, C., Mazlan, N., Chancellor, N., & Wells, D. (2021). The pen is milder than the blade: Identification marking mice using ink on the tail appears more humane than ear-punching even with local anaesthetic. Animals, 11, https://doi.org/10.3390/ani11061664

Identification marking mice commonly involves ear-punching with or without anaesthetic, or tail-marking with ink. To identify which is most humane, we marked male BALB/c mice using ear-punching (EP), ear-punching with anaesthetic EMLATM cream (EP+A),... Read More about The pen is milder than the blade: Identification marking mice using ink on the tail appears more humane than ear-punching even with local anaesthetic.

Future research priorities in canine epilepsy: viewpoints of owners, general practice veterinarians and neurology specialists (2021)
Journal Article
Jones, G., Volk, H., & Packer, R. (in press). Future research priorities in canine epilepsy: viewpoints of owners, general practice veterinarians and neurology specialists. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16144

Background: Epilepsy is the most common chronic neurological disease in dogs that impacts the quality of life (QoL) of affected dogs and their owners. Canine epilepsy research is expanding internationally, but where best to focus limited research tim... Read More about Future research priorities in canine epilepsy: viewpoints of owners, general practice veterinarians and neurology specialists.

Proportion and risk factors for death by euthanasia in dogs in the UK (2021)
Journal Article
O'Neill, D., Pegram, C., Gray, C., Packer, R. M., Richards, Y., Church, D. B., …O’Neill, D. G. (2021). Proportion and risk factors for death by euthanasia in dogs in the UK. International Journal of Advanced Scientific Engineering and Technological Research, https://doi.org/10.1038/s41598-021-88342-0

Objectives: To report proportional euthanasia or unassisted death, as well as the demographic and clinical factors associated with euthanasia, in dogs under primary veterinary care in the UK. Methods: A cohort study design to estimate proportional... Read More about Proportion and risk factors for death by euthanasia in dogs in the UK.

Integrating protein networks and machine learning for disease stratification in the Hereditary Spastic Paraplegias (2021)
Journal Article
Vavouraki, N., Tomkins, J. E., Kara, E., Houlden, H., Hardy, J., Tindall, M. J., …Manzoni, C. (2021). Integrating protein networks and machine learning for disease stratification in the Hereditary Spastic Paraplegias. iScience, 102484. https://doi.org/10.1016/j.isci.2021.102484

Handling mice using gloves sprayed with alcohol-based hand sanitiser: acute effects on mouse behaviour (2021)
Journal Article
Burn, C., Lopez Salesansky, N., Wells, D., Whitfield, L., & Chancellor, N. (2021). Handling mice using gloves sprayed with alcohol-based hand sanitiser: acute effects on mouse behaviour. Animal Technology and Welfare, 20, 11-20

Alcohols are commonly used in laboratory animal facilities to disinfect hands, equipment and laboratory environments. The effect on mice is unknown, so we observed male and female C57BL/6J and BALB/c mice during and after handling with nitrile gloves... Read More about Handling mice using gloves sprayed with alcohol-based hand sanitiser: acute effects on mouse behaviour.

Social buffering in horses is influenced by context but not by the familiarity and habituation of a companion (2021)
Journal Article
C, R., CJ, N., T, R., & DS, M. (2021). Social buffering in horses is influenced by context but not by the familiarity and habituation of a companion. Scientific Reports, https://doi.org/10.1038/s41598-021-88319-z

Social buffering applies when a companion can help to reduce the subject’s stress response during a stressful event and/or help to recover more quickly from a stressful event. The aim of this study was to determine if the social buffering function of... Read More about Social buffering in horses is influenced by context but not by the familiarity and habituation of a companion.

Global network analysis in Schizosaccharomyces pombe reveals three distinct consequences of the common 1-kb deletion causing juvenile CLN3 disease (2021)
Journal Article
Russell, C., Minnis, C. J., Townsend, S., Petschnigg, J., Tinelli, E., Bähler, J., …Mole, S. E. (2021). Global network analysis in Schizosaccharomyces pombe reveals three distinct consequences of the common 1-kb deletion causing juvenile CLN3 disease. Scientific Reports,

Juvenile CLN3 disease is a recessively inherited paediatric neurodegenerative disorder, with most patients homozygous for a 1-kb intragenic deletion in CLN3. The btn1 gene is the Schizosaccharomyces pombe orthologue of CLN3. Here, we have extended th... Read More about Global network analysis in Schizosaccharomyces pombe reveals three distinct consequences of the common 1-kb deletion causing juvenile CLN3 disease.

Early life exposure to air pollution impacts neuronal and glial cell function leading to impaired neurodevelopment (2021)
Journal Article
Morris, R. H., Counsell, S. J., McGonnell, I. M., & Thornton, C. (in press). Early life exposure to air pollution impacts neuronal and glial cell function leading to impaired neurodevelopment. BioEssays, 2000288. https://doi.org/10.1002/bies.202000288

The World Health Organisation recently listed air pollution as the most significant threat to human health. Air pollution comprises particulate matter (PM), metals, black carbon and gases such as ozone (O3), nitrogen dioxide (NO2) and carbon monoxide... Read More about Early life exposure to air pollution impacts neuronal and glial cell function leading to impaired neurodevelopment.

Sensitivity of the Natriuretic Peptide/cGMP System to Hyperammonaemia in Rat C6 Glioma Cells and GPNT Brain Endothelial Cells (2021)
Journal Article
Regan, J., Mirczuk, S., Scudder, C., Stacey, E., Khan, S., Powles, T., …Fowkes, R. (2021). Sensitivity of the Natriuretic Peptide/cGMP System to Hyperammonaemia in Rat C6 Glioma Cells and GPNT Brain Endothelial Cells. Cells, https://doi.org/10.3390/cells10020398

C-type natriuretic peptide (CNP) is the major natriuretic peptide of the central nervous system and acts via its selective guanylyl cyclase-B (GC-B) receptor to regulate cGMP production in neurons, astrocytes and endothelial cells. CNP is implicated... Read More about Sensitivity of the Natriuretic Peptide/cGMP System to Hyperammonaemia in Rat C6 Glioma Cells and GPNT Brain Endothelial Cells.

Pituitary Neoplasm Nomenclature Workshop: Does Adenoma Stand the Test of Time? (2021)
Journal Article
Ho, K., Fleseriu, M., Kaiser, U., Salvatori, R., Brue, T., Lopes, M. B., …Melmed, S. (2021). Pituitary Neoplasm Nomenclature Workshop: Does Adenoma Stand the Test of Time?. Journal of the Endocrine Society, 5(3), https://doi.org/10.1210/jendso/bvaa205

The WHO Classification of Endocrine Tumours designates pituitary neoplasms as adenomas. A proposed nomenclature change to pituitary neuroendocrine tumors (PitNETs) has been met with concern by some stakeholder groups. The Pituitary Society coordinate... Read More about Pituitary Neoplasm Nomenclature Workshop: Does Adenoma Stand the Test of Time?.

The role of mitochondria in cocaine addiction (2021)
Journal Article
Thornton, C., Grad, E., & Yaka, R. (in press). The role of mitochondria in cocaine addiction. Biochemical Journal,

The incidence of cocaine abuse is increasing especially in the UK where the rates are among the highest in Europe. In addition to its role as a psychostimulant, cocaine has profound effect on brain metabolism, impacting glycolysis and impairing oxida... Read More about The role of mitochondria in cocaine addiction.

Exploratory behaviour towards novel objects is associated with enhanced learning in young horses (2021)
Journal Article
Winther Christensen, J., Peerstrup Ahrendt, L., Malmkvist, J., & Nicol, C. (2021). Exploratory behaviour towards novel objects is associated with enhanced learning in young horses. Scientific Reports,

The mechanisms underlying individual variation in learning are key to understanding the development of cognitive abilities. In humans and primates, curiosity has been suggested as an important intrinsic factor that enhances learning, whereas in domes... Read More about Exploratory behaviour towards novel objects is associated with enhanced learning in young horses.