Outputs (34)

Applied mechanical loading to mouse hindlimb acutely increases skeletal perfusion and chronically enhanced vascular porosity (2020)
Journal Article
Gohin, S., Javaheri, B., Hopkinson, M., Pitsillides, A. A., Arnett, T. R., & Chenu, C. (2020). Applied mechanical loading to mouse hindlimb acutely increases skeletal perfusion and chronically enhanced vascular porosity. Journal of Applied Physiology,

Blood supply is essential for osteogenesis, yet its relationship to load-related increases in bone mass is poorly defined. Herein, we aim to investigate the link between load-induced osteogenesis and the blood supply (bone perfusion and vascular poro... Read More about Applied mechanical loading to mouse hindlimb acutely increases skeletal perfusion and chronically enhanced vascular porosity.

Osteoarthritis-related nociceptive behaviour following mechanical joint loading correlates with cartilage damage (2020)
Journal Article
Ter Heegde, F., Luiz, A. P., Santana-Varela, S., Magnusdottir, R., Hopkinson, M., Chang, Y. M., …Chenu, C. (2020). Osteoarthritis-related nociceptive behaviour following mechanical joint loading correlates with cartilage damage. Osteoarthritis and Cartilage, 28(3), 383-395. https://doi.org/10.1016/j.joca.2019.12.004

In osteoarthritis (OA), the pain-structure relationship remains complex and poorly understood. Here, we used the mechanical joint loading (MJL) model of OA to investigate both knee pathology and nociceptive behaviour.

Non-invasive mechanical joint loading as an alternative model for osteoarthritic pain (2019)
Journal Article
Ter Heegde, F., Luiz, A. P., Santana-Varela, S., Chessell, I. P., Welsh, F., Wood, J. N., & Chenu, C. (2019). Non-invasive mechanical joint loading as an alternative model for osteoarthritic pain. https://doi.org/10.1002/art.40835

Bidirectional regulation of bone formation by exogenous and osteosarcoma-derived Sema3A (2018)
Journal Article
De Ridder, D., Marino, S., Bishop, R. T., Renema, N., Chenu, C., Heymann, D., & Idris, A. I. (2018). Bidirectional regulation of bone formation by exogenous and osteosarcoma-derived Sema3A. https://doi.org/10.1038/s41598-018-25290-2

Semaphorin 3A (Sema3A), a secreted member of the Semaphorin family, increases osteoblast differentiation, stimulates bone formation and enhances fracture healing. Here, we report a previously unknown role of Sema3A in the regulation of ectopic bone f... Read More about Bidirectional regulation of bone formation by exogenous and osteosarcoma-derived Sema3A.

Novel skeletal effects of glucagon-like peptide-1 (GLP-1) receptor agonists (2018)
Journal Article
Mabilleau, G., Pereira, M., & Chenu, C. (2018). Novel skeletal effects of glucagon-like peptide-1 (GLP-1) receptor agonists. Journal of Endocrinology, 236, R29-R42. https://doi.org/10.1530/JOE-17-0278

Type 2 diabetes mellitus (T2DM) leads to bone fragility and predisposes to increased risk of fracture, poor bone healing and other skeletal complications. In addition, some anti-diabetic therapies for T2DM can have notable detrimental skeletal effect... Read More about Novel skeletal effects of glucagon-like peptide-1 (GLP-1) receptor agonists.

Exenatide Improves Bone Quality in a Murine Model of Genetically Inherited Type 2 Diabetes Mellitus (2017)
Journal Article
Pereira, M., Gohin, S., Roux, J., Fisher, A., Cleasby, M. E., Mabilleau, G., & Chenu, C. (2017). Exenatide Improves Bone Quality in a Murine Model of Genetically Inherited Type 2 Diabetes Mellitus. Frontiers in Endocrinology, 8(327), https://doi.org/10.3389/fendo.2017.00327

Type 2 diabetes mellitus (T2DM) is associated with skeletal complications, including an increased risk of fractures. Reduced blood supply and bone strength may contribute to this skeletal fragility. We hypothesized that long-term administration of... Read More about Exenatide Improves Bone Quality in a Murine Model of Genetically Inherited Type 2 Diabetes Mellitus.

Prolonging disuse in aged mice amplifies cortical but not trabecular bones’ response to mechanical loading (2017)
Journal Article
De Souza, R., Javaheri, B., Collinson, R. S., Chenu, C., Shefelbine, S., Lee, P. D., & Pitsillides, A. A. (2017). Prolonging disuse in aged mice amplifies cortical but not trabecular bones’ response to mechanical loading

Sclerostin does not play a major role in the pathogenesis of skeletal complications in type 2 diabetes mellitus (2017)
Journal Article
Pereira, M., Gohin, S., Lund, N., Hvid, A., Smitham, P. J., Oddy, M. J., …Chenu, C. (2017). Sclerostin does not play a major role in the pathogenesis of skeletal complications in type 2 diabetes mellitus. Osteoporosis International, 28(1), 309-320. https://doi.org/10.1007/s00198-016-3718-0

Expression of Sulf1 and Sulf2 in cartilage, bone and endochondral fracture healing (2016)
Journal Article
Zaman, G., Staines, K. A., Farquharson, C., Newton, P. T., Dudhia, J., Chenu, C., …Dhoot, G. K. (2016). Expression of Sulf1 and Sulf2 in cartilage, bone and endochondral fracture healing. Histochemistry and Cell Biology, 145(1), 67-79. https://doi.org/10.1007/s00418-015-1365-8

Chronic administration of Glucagon-like peptide-1 receptor agonists improves trabecular bone mass and architecture in ovariectomised mice (2015)
Journal Article
Pereira, M., Jeyabalan, J., Jorgensen, C. S., Hopkinson, M., Al-Jazzar, A., Roux, J. P., …Chenu, C. (2015). Chronic administration of Glucagon-like peptide-1 receptor agonists improves trabecular bone mass and architecture in ovariectomised mice. BONE, 81, 459-67. https://doi.org/10.1016/j.bone.2015.08.006

Some anti-diabetic therapies can have adverse effects on bone health and increase fracture risk. In this study, we tested the skeletal effects of chronic administration of two Glucagon-like peptide-1 receptor agonists (GLP-1RA), increasingly used for... Read More about Chronic administration of Glucagon-like peptide-1 receptor agonists improves trabecular bone mass and architecture in ovariectomised mice.