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Neuroprotective exendin-4 enhances hypothermia therapy in a model of hypoxic-ischaemic encephalopathy (2018)
Journal Article
Rocha-Ferreira, E., Poupon, L., Zelco, A., Leverin, A. L., Nair, S., Jonsdotter, A., …Rahim, A. A. (2018). Neuroprotective exendin-4 enhances hypothermia therapy in a model of hypoxic-ischaemic encephalopathy. Brain, 141(10), 2925-2942. https://doi.org/10.1093/brain/awy220

Hypoxic-ischaemic encephalopathy remains a global health burden. Despite medical advances and treatment with therapeutic hypothermia, over 50% of cooled infants are not protected and still develop lifelong neurodisabilities, including cerebral palsy.... Read More about Neuroprotective exendin-4 enhances hypothermia therapy in a model of hypoxic-ischaemic encephalopathy.

Simulation of muscle-powered jumping with hardware-in-the-loop ground interaction (2018)
Journal Article
Eberhard, E. A., & Richards, C. T. (2018). Simulation of muscle-powered jumping with hardware-in-the-loop ground interaction. https://doi.org/10.1109/AIM.2018.8452298

We developed a novel reverse haptic interface to augment forward dynamic simulations with real-world contact forces. In contrast with traditional haptics, in which a realworld user drives an interaction with a simulated environment, reverse haptics a... Read More about Simulation of muscle-powered jumping with hardware-in-the-loop ground interaction.

Common Traits Spark the Mitophagy/Xenophagy Interplay (2018)
Journal Article
Singh, A., Kendall, S. L., & Campanella, M. (2018). Common Traits Spark the Mitophagy/Xenophagy Interplay. Frontiers in Physiology, 9, https://doi.org/10.3389/fphys.2018.01172

Selective autophagy contributes to the wellbeing of eukaryotic cells by recycling cellular components, disposing damaged organelles, and removing pathogens, amongst others. Both the quality control process of selective mitochondrial autophagy (Mitoph... Read More about Common Traits Spark the Mitophagy/Xenophagy Interplay.

The scaling or ontogeny of human gait kinetics and walk-run transition: The implications of work vs. peak power minimization (2018)
Journal Article
Usherwood, J. R., Hubel, T. Y., Smith, B. J. H., Self Davies, Z. T., & Sobota, G. (2018). The scaling or ontogeny of human gait kinetics and walk-run transition: The implications of work vs. peak power minimization. Journal of Biomechanics, 81, 12-21. https://doi.org/10.1016/j.jbiomech.2018.09.004

A simple model is developed to find vertical force profiles and stance durations that minimize either limb mechanical work or peak power demands during bipedal locomotion. The model predicts that work minimization is achieved with a symmetrical verti... Read More about The scaling or ontogeny of human gait kinetics and walk-run transition: The implications of work vs. peak power minimization.

C-Type Natriuretic Peptide (CNP) Inhibition of Interferon-γ-Mediated Gene Expression in Human Endothelial Cells In Vitro (2018)
Journal Article
Day, A., Jameson, Z., Hyde, C., Simbi, B. H., Fowkes, R. C., & Lawson, C. (2018). C-Type Natriuretic Peptide (CNP) Inhibition of Interferon-γ-Mediated Gene Expression in Human Endothelial Cells In Vitro. Biosensors, 8(3), https://doi.org/10.3390/bios8030086

Cardiovascular diseases, including atherosclerosis, now account for more deaths in the Western world than from any other cause. Atherosclerosis has a chronic inflammatory component involving Th1 pro-inflammatory cytokines such as IFN-γ, which is know... Read More about C-Type Natriuretic Peptide (CNP) Inhibition of Interferon-γ-Mediated Gene Expression in Human Endothelial Cells In Vitro.

HUWE1 E3 ligase promotes PINK1/PARKINindependent mitophagy by regulating AMBRA1 activation via IKKa (2018)
Journal Article
Di Rita, A., Peschiaroli, A., D'Acunzo, P., Strobbe, D., Hu, Z., Gruber, J., …Cecconi, F. (2018). HUWE1 E3 ligase promotes PINK1/PARKINindependent mitophagy by regulating AMBRA1 activation via IKKa. Nature Communications, 9(3755), https://doi.org/10.1038/s41467-018-05722-3

The selective removal of undesired or damaged mitochondria by autophagy, known as mitophagy, is crucial for cellular homoeostasis, and prevents tumour diffusion, neurodegeneration and ageing. The pro-autophagic molecule AMBRA1 (autophagy/beclin-1 reg... Read More about HUWE1 E3 ligase promotes PINK1/PARKINindependent mitophagy by regulating AMBRA1 activation via IKKa.

The dynamic role of the ilio-sacral joint in jumping frogs (2018)
Journal Article
Richards, C. T., Eberhard, E. A., & Collings, A. J. (2018). The dynamic role of the ilio-sacral joint in jumping frogs. Biology Letters, 14(9), https://doi.org/10.1098/rsbl.2018.0367

A striking feature among jumping frogs is a sharp pelvic bend about the ilio-sacral (IS) joint, unique to anurans. Although this sagittal plane hinge has been interpreted as crucial for the evolution of jumping, its mechanical contribution has not be... Read More about The dynamic role of the ilio-sacral joint in jumping frogs.

Scans for signatures of selection in Russian cattle breed genomes reveal new candidate genes for environmental adaptation and acclimation (2018)
Journal Article
Yurchenko, A. A., Daetwyler, H. D., Yudin, N., Schnabel, R. D., Vander Jagt, C. J., Soloshenko, V., …Larkin, D. M. (2018). Scans for signatures of selection in Russian cattle breed genomes reveal new candidate genes for environmental adaptation and acclimation. https://doi.org/10.1038/s41598-018-31304-w

Domestication and selective breeding has resulted in over 1000 extant cattle breeds. Many of these breeds do not excel in important traits but are adapted to local environments. These adaptations are a valuable source of genetic material for efforts... Read More about Scans for signatures of selection in Russian cattle breed genomes reveal new candidate genes for environmental adaptation and acclimation.