Common Traits Spark the Mitophagy/Xenophagy Interplay

Singh, A; Kendall, S L; Campanella, M

doi:10.3389/fphys.2018.01172

Common Traits Spark the Mitophagy/Xenophagy Interplay

Singh, A; Kendall, S L; Campanella, M

Authors

A Singh

S L Kendall

M Campanella

Abstract

Selective autophagy contributes to the wellbeing of eukaryotic cells by recycling cellular components, disposing damaged organelles, and removing pathogens, amongst others. Both the quality control process of selective mitochondrial autophagy (Mitophagy) and the defensive process of intracellular pathogen-engulfment (Xenophagy) are facilitated via protein assemblies which have shared molecules, a prime example being the Tank-Binding Kinase 1 (TBK1). TBK1 plays a central role in the immunity response driven by Xenophagy and was recently shown to be an amplifying mechanism in Mitophagy, bring to attention the potential cross talk between the two processes. Here we draw parallels between Xenophagy and Mitophagy, speculating on the inhibitory mechanisms of specific proteins (e.g., the 18 kDa protein TSPO), how the preferential sequestering toward one of the two pathways may undermine the other, and in this way impair cellular response to pathogens and cellular immunity. We believe that an in depth understanding of the commonalities may present an opportunity to design novel therapeutic strategies targeted at both the autonomous and non-autonomous processes of selective autophagy.

Citation

Singh, A., Kendall, S. L., & Campanella, M. (2018). Common Traits Spark the Mitophagy/Xenophagy Interplay. Frontiers in Physiology, 9, https://doi.org/10.3389/fphys.2018.01172

Journal Article Type	Review
Acceptance Date	Aug 3, 2018
Publication Date	Sep 20, 2018
Deposit Date	Mar 7, 2019
Publicly Available Date	Mar 8, 2019
Journal	Frontiers in Physiology
Electronic ISSN	1664-042X
Publisher	Frontiers Media
Peer Reviewed	Peer Reviewed
Volume	9
DOI	https://doi.org/10.3389/fphys.2018.01172
Public URL	https://rvc-repository.worktribe.com/output/1385812