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Outputs (2401)

Dynamic changes in gene expression and signalling during trophoblast development in the horse (2018)
Journal Article
Read, J. E., Cabrera-Sharp, V., Offord, V., Mirczuk, S. M., Allen, S. P., Fowkes, R. C., & De Mestre, A. M. (2018). Dynamic changes in gene expression and signalling during trophoblast development in the horse. Reproduction, 156(4), 313-330. https://doi.org/10.1530/REP-18-0270

Equine chorionic girdle trophoblast cells play important endocrine and immune functions critical in supporting pregnancy. Very little is known about the genes and pathways that regulate chorionic girdle trophoblast development. Our aim was to identif... Read More about Dynamic changes in gene expression and signalling during trophoblast development in the horse.

Disrupting LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation (2018)
Journal Article
Gage, M. C., Becares, N., Louie, R., Waddington, K. E., Zhang, Y., Tittanegro, T. H., …Pineda-Torra, I. (2018). Disrupting LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation. Proceedings of the National Academy of Sciences, 115(28), E6556-E6565. https://doi.org/10.1073/pnas.1721245115

Macrophages are key immune cells for the initiation and development of atherosclerotic lesions. However, the macrophage regulatory nodes that determine how lesions progress in response to dietary challenges are not fully understood. Liver X receptors... Read More about Disrupting LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation.

Disrupting myeloid-specific LXRa phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation (2018)
Journal Article
Gage, M. C., Becares, N., Louie, R., Waddington, K. E., Zhang, Y., Tittanegro, T. H., …Pineda-Torra, I. (2018). Disrupting myeloid-specific LXRa phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation. https://doi.org/10.1073/pnas.1721245115

Macrophages are key immune cells for the initiation and development of atherosclerotic lesions. However, the macrophage regulatory nodes that determine how lesions progress in response to dietary challenges are not fully understood. Liver X receptors... Read More about Disrupting myeloid-specific LXRa phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation.

Cell specific microvesicles vary with season and disease predisposition in healthy and previously laminitic ponies (2018)
Journal Article
Finding, E. J. T., Lawson, C., Elliott, J., Harris, P. A., & Menzies-Gow, N. J. (2018). Cell specific microvesicles vary with season and disease predisposition in healthy and previously laminitic ponies. Veterinary Immunology and Immunopathology, https://doi.org/10.1016/j.vetimm.2018.06.001

Microvesicles are small (up to 1 μm) vesicles found in plasma and other bodily fluids. They are recognised as part of the normal system of inter-cellular communication but altered numbers are also used as biomarkers of disease. Microvesicles have not... Read More about Cell specific microvesicles vary with season and disease predisposition in healthy and previously laminitic ponies.

Seasonal and dietary influences on adipose tissue and systemic gene expression in control and previously laminitic ponies (2018)
Journal Article
Timpson, A., De Mestre, A. M., Elliott, J., Harris, P. A., Cheng, Z. R., Mirczuk, S. M., …Menzies-Gow, N. J. (2018). Seasonal and dietary influences on adipose tissue and systemic gene expression in control and previously laminitic ponies. Journal of Equine Veterinary Science, https://doi.org/10.1016/j.jevs.2018.06.009

The aims of the study were to determine whether adipose tissue global gene expression (i) differs between never laminitic (NL) and previously laminitic (PL) ponies; (ii) is influenced by season and/or a diet designed to simulate spring grass and (iii... Read More about Seasonal and dietary influences on adipose tissue and systemic gene expression in control and previously laminitic ponies.

Construction of Red Fox Chromosomal Fragments from the Short-Read Genome Assembly (2018)
Journal Article
Rando, H., Farré, M., Robson, M., Won, N., Johnson, J., Buch, R., …Kukekova, A. (2018). Construction of Red Fox Chromosomal Fragments from the Short-Read Genome Assembly. Genes, 9(6), 308. https://doi.org/10.3390/genes9060308

The genome of a red fox (Vulpes vulpes) was recently sequenced and assembled using next-generation sequencing (NGS). The assembly is of high quality, with 94X coverage and a scaffold N50 of 11.8 Mbp, but is split into 676,878 scaffolds, some of which... Read More about Construction of Red Fox Chromosomal Fragments from the Short-Read Genome Assembly.

A novel kinematics analysis method using quaternion interpolation – a case study in frog jumping (2018)
Journal Article
Richards, C. T., & Porro, L. B. (2018). A novel kinematics analysis method using quaternion interpolation – a case study in frog jumping. Journal of Theoretical Biology, 454, 410-424. https://doi.org/10.1016/j.jtbi.2018.06.010

Spherical Linear Interpolation (SLERP) has long been used in computer animation to interpolate movements between two 3D orientations. We developed a forward kinematics (FK) approach using quaternions and SLERP to predict how frogs modulate jump kinem... Read More about A novel kinematics analysis method using quaternion interpolation – a case study in frog jumping.