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Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing (2015)
Journal Article
Javaheri, B., Carriero, A., Staines, K. A., Chang, Y. M., Houston, D. A., Oldknow, K. J., …Pitsillides, A. A. (2015). Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing. BONE, 81, 277-291. https://doi.org/10.1016/j.bone.2015.07.035

PHOSPHO1 is one of principal proteins involved in initiating bone matrix mineralisation. Recent studies have found that Phospho1 KO mice (Phospho1-R74X) display multiple skeletal abnormalities with spontaneous fractures, bowed long bones, osteomalaci... Read More about Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing.

Effect of oleic acid supplementation on prostaglandin production in maternal endometrial and fetal allantochorion cells isolated from late gestation ewes (2015)
Journal Article
Cheng, Z. R., Abayasekara, D. R. E., Elmes, M., Kirkup, S. E., & Wathes, D. C. (2015). Effect of oleic acid supplementation on prostaglandin production in maternal endometrial and fetal allantochorion cells isolated from late gestation ewes. Placenta, 36(9), 1011-1017. https://doi.org/10.1016/j.placenta.2015.07.128

Elevated circulating non-esterified fatty acids including oleic acid (OA) are associated with many pregnancy related complications. Prostaglandins (PGs) play crucial roles during parturition. We investigated the effect of OA supplementation on PG pro... Read More about Effect of oleic acid supplementation on prostaglandin production in maternal endometrial and fetal allantochorion cells isolated from late gestation ewes.

Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation (2015)
Journal Article
Kirkby, N. S., Reed, D. M., Edin, M. L., Rauzi, F., Mataragka, S., Vojnovic, I., …Warner, T. D. (2015). Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation. FASEB Journal, 29(11), 4568-4578. https://doi.org/10.1096/fj.15-275065

Eicosanoids are important vascular regulators, but the phospholipase A2 (PLA2) isoforms supporting their production within the cardiovascular system are not fully understood. To address this, we have studied platelets, endothelial cells, and leukocyt... Read More about Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation.

Aggregated a-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons (2015)
Journal Article
Reeve, A. K., Ludtmann, M. H. R., Angelova, P. R., Simcox, E. M., Horrocks, M. H., Klenerman, D., …Abramov, A. Y. (2015). Aggregated a-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons. https://doi.org/10.1038/cddis.2015.166

α-Synuclein becomes misfolded and aggregated upon damage by various factors, for example, by reactive oxygen species. These aggregated forms have been proposed to have differential toxicities and their interaction with mitochondria may cause dysfunct... Read More about Aggregated a-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons.

Tendon overload results in alterations in cell shape and increased markers of inflammation and matrix degradation (2015)
Journal Article
Thorpe, C. T., Chaudhry, S., Lei, I., Varone, A., Riley, G. P., Birch, H. L., …Screen, H. R. (2015). Tendon overload results in alterations in cell shape and increased markers of inflammation and matrix degradation. https://doi.org/10.1111/sms.12333

Tendon injury is thought to involve both damage accumulation within the matrix and an accompanying cell response. While several studies have characterized cell and matrix response in chronically injured tendons, few have assessed the initial response... Read More about Tendon overload results in alterations in cell shape and increased markers of inflammation and matrix degradation.

Lipopolysaccharide and toll-like receptor 4 in dogs with congenital portosystemic shunts (2015)
Journal Article
Tivers, M. S., Lipscomb, V. J., Smith, K. C., Wheeler-Jones, C. P. D., & House, A. K. (2015). Lipopolysaccharide and toll-like receptor 4 in dogs with congenital portosystemic shunts. https://doi.org/10.1016/j.tvjl.2015.07.006

Surgical attenuation of a congenital portosystemic shunt (CPSS) results in increased portal vein perfusion, liver growth and clinical improvement. Portal lipopolysaccharide (LPS) is implicated in liver regeneration via toll-like receptor (TLR) 4 medi... Read More about Lipopolysaccharide and toll-like receptor 4 in dogs with congenital portosystemic shunts.

The complex aerodynamic footprint of desert locusts revealed by large-volume tomographic particle image velocimetry (2015)
Journal Article
Henningsson, P., Michaelis, D., Nakata, T., Schanz, D., Geisler, R., Schroeder, A., & Bomphrey, R. J. (2015). The complex aerodynamic footprint of desert locusts revealed by large-volume tomographic particle image velocimetry. https://doi.org/10.1098/rsif.2015.0119

Particle image velocimetry has been the preferred experimental technique with which to study the aerodynamics of animal flight for over a decade. In that time, hardware has become more accessible and the software has progressed from the acquisition o... Read More about The complex aerodynamic footprint of desert locusts revealed by large-volume tomographic particle image velocimetry.