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Functional adaptation to mechanical loading in both cortical and cancellous bone is controlled locally and is confined to the loaded bones (2010)
Journal Article
Sugiyama, T., Price, J. S., & Lanyon, L. E. (2010). Functional adaptation to mechanical loading in both cortical and cancellous bone is controlled locally and is confined to the loaded bones. BONE, 46(2), 314-321. https://doi.org/10.1016/j.bone.2009.08.054

In order to validate whether bones' functional adaptation to mechanical loading is a local phenomenon, we randomly assigned 21 female C57BL/6 mice at 19 weeks of age to one of three equal numbered groups. All groups were treated with isoflurane anest... Read More about Functional adaptation to mechanical loading in both cortical and cancellous bone is controlled locally and is confined to the loaded bones.

Assessment of dairy cow locomotion in a commercial farm setting: the effects of walking speed on ground reaction forces and temporal and linear stride characteristics (2010)
Journal Article
Walker, A. M., Pfau, T., Channon, A. J., & Wilson, A. M. (2010). Assessment of dairy cow locomotion in a commercial farm setting: the effects of walking speed on ground reaction forces and temporal and linear stride characteristics. Research in Veterinary Science, 88, 179-187. https://doi.org/10.1016/j.rvsc.2009.05.016

Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-esclation, proof-of-concept study (2009)
Journal Article
Kinali, M., Arechavala-Gomeza, V., Feng, L., Cirak, S., Hunt, D., Adkin, C., …Muntoni, F. (2009). Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-esclation, proof-of-concept study. https://doi.org/10.1016/S1474-4422%2809%2970211-X

Activin signals via SMAD2/3 between germ and somatic cells in the human fetal ovary and regulates kit ligand expression (2008)
Journal Article
Coutts, S. M., Childs, A. J., Fulton, N., Collins, C., Bayne, R. A. L., McNeilly, A. S., & Anderson, R. A. (2008). Activin signals via SMAD2/3 between germ and somatic cells in the human fetal ovary and regulates kit ligand expression. Developmental Biology, 314(1), 189-199. https://doi.org/10.1016/j.ydbio.2007.11.026

Ovarian germ cell survival is dependent upon the formation of primordial follicles, which occurs during fetal life in the human. Activin contributes to germ cell proliferation and survival at this time. SMADs2 and 3 are central elements in the activi... Read More about Activin signals via SMAD2/3 between germ and somatic cells in the human fetal ovary and regulates kit ligand expression.

What use is anatomy in first opinion small animal veterinary practice? A qualitative study
Journal Article
Wheble, R., & Channon, S. (in press). What use is anatomy in first opinion small animal veterinary practice? A qualitative study. Anatomical Sciences Education, https://doi.org/10.1002/ase.1995

Despite the uncontested importance of anatomy as one of the foundational aspects of undergraduate veterinary programs, there is still limited information available as to what anatomy knowledge is most important for the graduate veterinarian in their... Read More about What use is anatomy in first opinion small animal veterinary practice? A qualitative study.

Extreme heterogeneity in sex chromosome differentiation and dosage compensation in livebearers
Journal Article
Darolti, I., Wright, A. E., Sandkam, B. A., Morris, J., Bloch, N. I., Farré, M., …Mank, J. E. (in press). Extreme heterogeneity in sex chromosome differentiation and dosage compensation in livebearers. https://doi.org/10.1073/pnas.1905298116

Morphologically and functionally distinct X and Y chromosomes have repeatedly evolved across the tree of life. However, the extent of differentiation between the sex chromosomes varies substantially across species. As sex chromosomes diverge, the Y c... Read More about Extreme heterogeneity in sex chromosome differentiation and dosage compensation in livebearers.

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease
Journal Article
Jadiya, P., Kolmetzky, D. W., Tomar, D., Di Meco, A., Lombardi, A. A., Lambert, J. P., …Elrod, J. W. (in press). Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease. Nature Communications, 10(3885), https://doi.org/10.1038/s41467-019-11813-6

Impairments in neuronal intracellular calcium (iCa2+) handling may contribute to Alzheimer’s disease (AD) development. Metabolic dysfunction and progressive neuronal loss are associated with AD progression, and mitochondrial calcium (mCa2+) signaling... Read More about Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease.

Ropinirole eye drops induce vomiting effectively in dogs: a randomised, double-blind, placebo-controlled clinical study
Journal Article
Suokko, M., Saloranta, L., Lamminen, T., Laine, T., & Elliott, J. (in press). Ropinirole eye drops induce vomiting effectively in dogs: a randomised, double-blind, placebo-controlled clinical study. Veterinary Record, https://doi.org/10.1136/vr.104953

There is a need for an effective and safe emetic agent that dog owners could easily administer to their dogs following veterinary advice in cases of potential poisoning. As a response to this need, a randomised, double-blind, multi-site, clinical fie... Read More about Ropinirole eye drops induce vomiting effectively in dogs: a randomised, double-blind, placebo-controlled clinical study.

Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis
Journal Article
Staines, K. A., Ikpegbu, E., Tornqvist, A. E., Dillon, S., Javaheri, B., Amin, A. K., …Farquharson, C. (in press). Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis. BMC Musculoskeletal Disorders, 20, https://doi.org/10.1186/s12891-019-2731-9

Subchondral bone (SCB) thickening is one of the earliest detectable changes in osteoarthritic joints and is considered a potential trigger for subsequent articular cartilage degeneration. In this manuscript, we examine whether disruption to the SCB o... Read More about Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis.