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LRRK2 deficiency induced mitochondrial Ca2+ efflux inhibition can be rescued by Na+/Ca2+/Li+ exchanger upregulation
Journal Article
Ludtmann, M. H. R., Kostic, M., Horne, A., Gandhi, S., Sekler, I., & Abramov, A. Y. (in press). LRRK2 deficiency induced mitochondrial Ca2+ efflux inhibition can be rescued by Na+/Ca2+/Li+ exchanger upregulation. https://doi.org/10.1038/s41419-019-1469-5

Variants of leucine-rich repeat kinase 2 (lrrk2) are associated with an increased risk in developing Parkinson’s disease (PD). Mitochondrial dysfunction and specifically mitochondrial Ca2+ handling has been linked to the pathogenesis of PD. Here we d... Read More about LRRK2 deficiency induced mitochondrial Ca2+ efflux inhibition can be rescued by Na+/Ca2+/Li+ exchanger upregulation.

External mechanical work in the galloping racehorse
Journal Article
Self Davies, Z. T., Spence, A. J., & Wilson, A. M. (in press). External mechanical work in the galloping racehorse. Biology Letters, 1, https://doi.org/10.1098/rsbl.2018.0709

Horse locomotion is remarkably economical. Here, we measure external mechanical work of the galloping horse and relate it to published measurements of metabolic cost. Seven Thoroughbred horses were galloped (ridden) over force plates, under a racing... Read More about External mechanical work in the galloping racehorse.

ACVIM consensus statement on the diagnosis of immune-mediated hemolytic anemia in dogs and cats
Journal Article
Garden, O. A., Kidd, L., Mexas, A. M., Chang, Y. M., Jeffrey, U., Blois, S. L., …Szladovits, B. (in press). ACVIM consensus statement on the diagnosis of immune-mediated hemolytic anemia in dogs and cats. Journal of Veterinary Medical Education, https://doi.org/10.1111/jvim.15441

Immune-mediated hemolytic anemia (IMHA) is an important cause of morbidity and mortality in dogs. IMHA also occurs in cats, although less commonly. IMHA is considered secondary when it can be attributed to an underlying disease, and as primary (idiop... Read More about ACVIM consensus statement on the diagnosis of immune-mediated hemolytic anemia in dogs and cats.

Is bisphenol S a safer alternative to bisphenol A in terms of potential fetal exposure ? Placental transfer across the perfused human placenta
Journal Article
Grandin, F. C., Lacroix, M. Z., Gayrard, V., Viguié, C., Mila, H., De Place, A., …Picard-Hagen, N. (in press). Is bisphenol S a safer alternative to bisphenol A in terms of potential fetal exposure ? Placental transfer across the perfused human placenta. Chemosphere, 221, 471-478. https://doi.org/10.1016/j.chemosphere.2019.01.065

The aim of our study was to evaluate the bidirectional transfer of Bisphenol S (BPS) and its main metabolite, BPS Glucuronide (BPSG), using the model of perfused human placenta and to compare the obtained values with those of Bisphenol A (BPA) and BP... Read More about Is bisphenol S a safer alternative to bisphenol A in terms of potential fetal exposure ? Placental transfer across the perfused human placenta.

AZD1208, a Pan-Pim Kinase Inhibitor, Has Anti-Growth Effect on 93T449 Human Liposarcoma Cells via Control of the Expression and Phosphorylation of Pim-3, mTOR, 4EBP-1, S6, STAT-3 and AMPK
Journal Article
Yadav, A. K., Kumar, V., Bishop-Bailey, D., & Jang, B. C. (in press). AZD1208, a Pan-Pim Kinase Inhibitor, Has Anti-Growth Effect on 93T449 Human Liposarcoma Cells via Control of the Expression and Phosphorylation of Pim-3, mTOR, 4EBP-1, S6, STAT-3 and AMPK. International Journal of Molecular Sciences, 20(2), https://doi.org/10.3390/ijms20020363

Overexpression of Pim kinases has an oncogenic/pro-survival role in many hematological and solid cancers. AZD1208 is a pan-Pim kinase inhibitor that has anti-cancer and anti-adipogenic actions. Here, we investigated the effects of AZD1208 on the grow... Read More about AZD1208, a Pan-Pim Kinase Inhibitor, Has Anti-Growth Effect on 93T449 Human Liposarcoma Cells via Control of the Expression and Phosphorylation of Pim-3, mTOR, 4EBP-1, S6, STAT-3 and AMPK.

Avian gust rejection in gliding flight through updrafts
Journal Article
Cheney, J. A., Stevenson, J. P. J., Durston, N. E., Usherwood, J. R., Bomphrey, R. J., & Windsor, S. P. Avian gust rejection in gliding flight through updrafts. Integrative and Comparative Biology, 59, E36