F C Grandin
Is bisphenol S a safer alternative to bisphenol A in terms of potential fetal exposure ? Placental transfer across the perfused human placenta
Grandin, F C; Lacroix, M Z; Gayrard, V; Viguié, C; Mila, H; De Place, A; Vayssière, C; Morin, M; Corbett, J; Gayrard, C; Gély, C A; Toutain, P-L; Picard-Hagen, N
M Z Lacroix
A De Place
C A Gély
The aim of our study was to evaluate the bidirectional transfer of Bisphenol S (BPS) and its main metabolite, BPS Glucuronide (BPSG), using the model of perfused human placenta and to compare the obtained values with those of Bisphenol A (BPA) and BPA Glucuronide.
Fourteen placentas at term were perfused in an open dual circuit with deuterated BPS (1 and 5??M) and non-labelled BPSG (2.5??M) and a freely diffusing marker antipyrine (800?ng/ml) in the presence of albumin (25?mg/ml). In a second experiment, the potential role of P-glycoprotein in the active efflux of BPS across the placental barrier was studied using the well-established P-glycoprotein inhibitor, PSC833 (2 and 4??M).
Placental transfer of BPS was much lower than that of BPA in both directions. The placental clearance index of BPS in the materno-fetal direction was three times lower than in the opposite direction, strongly suggesting some active efflux transport. However, our results show that P-glycoprotein is not involved in limiting the materno-fetal transfer of BPS. Placental transfer of BPSG in the fetal compartment was almost non-existent indicating that, in the fetal compartment, BPSG originates mainly from feto-placental metabolism. The feto-maternal clearance index for BPSG was 20-fold higher than the materno-fetal index.
We conclude that the blood-placental barrier is much more efficient in limiting fetal exposure to BPS than to BPA, indicating that the placenta has a crucial role in protecting the human fetus from BPS exposure.
Grandin, F. C., Lacroix, M. Z., Gayrard, V., Viguié, C., Mila, H., De Place, A., …Picard-Hagen, N. (in press). Is bisphenol S a safer alternative to bisphenol A in terms of potential fetal exposure ? Placental transfer across the perfused human placenta. Chemosphere, 221, 471-478. https://doi.org/10.1016/j.chemosphere.2019.01.065
|Journal Article Type||Article|
|Acceptance Date||Jan 9, 2019|
|Deposit Date||Mar 30, 2019|