Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering
Journal Article
Maffioletti, S. M., Sarcar, S., Henderson, A. B. H., Mannhardt, I., Pinton, L., Moyle, L. A., …Tedesco, F. S. (in press). Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering. Cell Reports, 23(3), 899-908. https://doi.org/10.1016/j.celrep.2018.03.091
Outputs (2401)
Differential Activity of the Combination of Vancomycin and Amikacin on Planktonic vs. Biofilm-Growing Staphylococcus aureus Bacteria in a Hollow Fiber Infection Model
Journal Article
Broussou, D. C., Lacroix, M. Z., Toutain, P. L., Woehrlé, F., El Garch, F., Bousquet-Mélou, A., & Ferran, A. A. (in press). Differential Activity of the Combination of Vancomycin and Amikacin on Planktonic vs. Biofilm-Growing Staphylococcus aureus Bacteria in a Hollow Fiber Infection Model. Frontiers in Microbiology, 9(572), https://doi.org/10.3389/fmicb.2018.00572Combining currently available antibiotics to optimize their use is a promising strategy to reduce treatment failures against biofilm-associated infections. Nevertheless, most assays of such combinations have been performed in vitro on planktonic bact... Read More about Differential Activity of the Combination of Vancomycin and Amikacin on Planktonic vs. Biofilm-Growing Staphylococcus aureus Bacteria in a Hollow Fiber Infection Model.
Risk factors for race-day fatality in flat racing Thoroughbreds in Great Britain (2000 to 2013)
Journal Article
Rosanowski, S. M., Chang, Y. M., Stirk, A. J., & Verheyen, K. L. P. (in press). Risk factors for race-day fatality in flat racing Thoroughbreds in Great Britain (2000 to 2013). PLoS ONE, 13(3), e0194299. https://doi.org/10.1371/journal.pone.0194299A key focus of the racing industry is to reduce the number of race-day events where horses die suddenly or are euthanased due to catastrophic injury. The objective of this study was therefore to determine risk factors for race-day fatalities in Thoro... Read More about Risk factors for race-day fatality in flat racing Thoroughbreds in Great Britain (2000 to 2013).
MURINE CRUCIATE LIGAMENT DEGENERATION AND MARKER EXPRESSION DURING OSTEOARTHRITIS
Journal Article
Ramos, L. D., Bou-Gharios, G., Pitsillides, A. A., Comerford, E. J., & Poulet, B. (in press). MURINE CRUCIATE LIGAMENT DEGENERATION AND MARKER EXPRESSION DURING OSTEOARTHRITIS. International Journal of Experimental Pathology, 98(6), A8-A9
Energy allocation and behaviour in the growing broiler chicken
Journal Article
Tickle, P. G., Hutchinson, J. R., & Codd, J. R. (in press). Energy allocation and behaviour in the growing broiler chicken. https://doi.org/10.1038/s41598-018-22604-2Broiler chickens are increasingly at the forefront of global meat production but the consequences of fast growth and selection for an increase in body mass on bird health are an ongoing concern for industry and consumers. To better understand the imp... Read More about Energy allocation and behaviour in the growing broiler chicken.
Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice
Journal Article
Orriss, I. R., Lanham, S. A., Savery, D., Greene, N. D. E., Stanier, P., Oreffo, R., …Galea, G. L. (in press). Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice. https://doi.org/10.1038/s41598-018-21718-xFractures are a common comorbidity in children with the neural tube defect (NTD) spina bifida. Mutations in the Wnt/planar cell polarity (PCP) pathway contribute to NTDs in humans and mice, but whether this pathway independently determines bone mass... Read More about Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice.
Direct interaction of oligomeric alpha-synuclein with ATP synthase leads to mitochondrial PTP opening in Parkinson’s disease
Journal Article
Ludtmann, M. H. R. Direct interaction of oligomeric alpha-synuclein with ATP synthase leads to mitochondrial PTP opening in Parkinson’s disease. Nature Communications,
Nutritional Programming Effects on the Immune System
Journal Article
Palmer, D. B. Nutritional Programming Effects on the Immune SystemThe relationship between patterns of early growth and age-associated diseases such as type 2 diabetes and cardiovascular disease is well established. There is also strong evidence from both human and animal studies that early environmental factors su... Read More about Nutritional Programming Effects on the Immune System.
Anxiolytic Therapy: A Paradigm of Successful Mitochondrial Pharmacology
Journal Article
Strobbe, D., & Campanella, M. Anxiolytic Therapy: A Paradigm of Successful Mitochondrial Pharmacology. Trends in Pharmacological Sciences, https://doi.org/10.1016/j.tips.2018.02.008
Mathematical modeling and simulation in animal health. Part III: Using nonlinear mixed-effects to characterize and quantify variability in drug pharmacokinetics
Journal Article
Bon, C., Toutain, P. L., Concordet, D., Martin-Jimenez, T., Gehring, R., Smith, J., …Mochel, J. P. (2017). Mathematical modeling and simulation in animal health. Part III: Using nonlinear mixed-effects to characterize and quantify variability in drug pharmacokinetics. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.12473