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Outputs (38)

C-Type Natriuretic Peptide (CNP) Inhibition of Interferon-γ-Mediated Gene Expression in Human Endothelial Cells In Vitro (2018)
Journal Article
Day, A., Jameson, Z., Hyde, C., Simbi, B. H., Fowkes, R. C., & Lawson, C. (2018). C-Type Natriuretic Peptide (CNP) Inhibition of Interferon-γ-Mediated Gene Expression in Human Endothelial Cells In Vitro. Biosensors, 8(3), https://doi.org/10.3390/bios8030086

Cardiovascular diseases, including atherosclerosis, now account for more deaths in the Western world than from any other cause. Atherosclerosis has a chronic inflammatory component involving Th1 pro-inflammatory cytokines such as IFN-γ, which is know... Read More about C-Type Natriuretic Peptide (CNP) Inhibition of Interferon-γ-Mediated Gene Expression in Human Endothelial Cells In Vitro.

Cell specific microvesicles vary with season and disease predisposition in healthy and previously laminitic ponies (2018)
Journal Article
Finding, E. J. T., Lawson, C., Elliott, J., Harris, P. A., & Menzies-Gow, N. J. (2018). Cell specific microvesicles vary with season and disease predisposition in healthy and previously laminitic ponies. Veterinary Immunology and Immunopathology, https://doi.org/10.1016/j.vetimm.2018.06.001

Microvesicles are small (up to 1 μm) vesicles found in plasma and other bodily fluids. They are recognised as part of the normal system of inter-cellular communication but altered numbers are also used as biomarkers of disease. Microvesicles have not... Read More about Cell specific microvesicles vary with season and disease predisposition in healthy and previously laminitic ponies.

Brugia malayi microfilariae adhere to human vascular endothelial cells in a C3-dependent manner (2017)
Journal Article
Schroeder, H., McCarthy, D., Szestak, T., Cook, D. A., Taylor, M., Craig, A. G., …Lawrence, R. A. (2017). Brugia malayi microfilariae adhere to human vascular endothelial cells in a C3-dependent manner. PLoS Neglected Tropical Diseases, 11(5), e0005592. https://doi.org/10.1371/journal.pntd.0005592

Brugia malayi causes the human tropical disease, lymphatic filariasis. Microfilariae (Mf) of this nematode live in the bloodstream and are ingested by a feeding mosquito vector. Interestingly, in a remarkable co-evolutionary adaptation, Mf appearance... Read More about Brugia malayi microfilariae adhere to human vascular endothelial cells in a C3-dependent manner.

Natriuretic peptide activation of extracellular regulated kinase 1/2 (ERK1/2) pathway by particulate guanylyl cyclases in GH3 somatolactotropes (2017)
Journal Article
Jonas, K. C., Melrose, T., Thompson, I. R., Baxter, G. F., Lipscomb, V. J., Niessen, S. J. M., …Fowkes, R. C. (2017). Natriuretic peptide activation of extracellular regulated kinase 1/2 (ERK1/2) pathway by particulate guanylyl cyclases in GH3 somatolactotropes. Cell and Tissue Research, 369(3), 567-578. https://doi.org/10.1007/s00441-017-2624-x

The natriuretic peptides, Atrial-, B-type and C-type natriuretric peptides (ANP, BNP, CNP), are regulators of many endocrine tissues and exert their effects predominantly through the activation of their specific guanylyl cyclase receptors (GC-A and G... Read More about Natriuretic peptide activation of extracellular regulated kinase 1/2 (ERK1/2) pathway by particulate guanylyl cyclases in GH3 somatolactotropes.

Leukocyte Adhesion Under Hemodynamic Flow Conditions (2017)
Journal Article
Lawson, C., Rose, M., & Wolf, S. (2017). Leukocyte Adhesion Under Hemodynamic Flow Conditions. https://doi.org/10.1007/978-1-4939-6931-9_7

Vascular endothelial cells (ECs) line the luminal side of all blood vessels and act as a selective barrier between blood and tissue. ECs are constantly exposed to biochemical and biomechanical stimuli from the blood and underlying tissue. Fluid shear... Read More about Leukocyte Adhesion Under Hemodynamic Flow Conditions.

Long-term high fat feeding of rats results in increased numbers of circulating microvesicles with pro-inflammatory effects on endothelial cells (2015)
Journal Article
Heinrich, L. F., Andersen, D. K., Cleasby, M. E., & Lawson, C. (2015). Long-term high fat feeding of rats results in increased numbers of circulating microvesicles with pro-inflammatory effects on endothelial cells. British Journal of Nutrition, 113(11), 1704-11. https://doi.org/10.1017/S0007114515001117

Obesity and type 2 diabetes lead to dramatically increased risks of atherosclerosis and CHD. Multiple mechanisms converge to promote atherosclerosis by increasing endothelial oxidative stress and up-regulating expression of pro-inflammatory molecules... Read More about Long-term high fat feeding of rats results in increased numbers of circulating microvesicles with pro-inflammatory effects on endothelial cells.