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Outputs (17)

Developmental Origin of Oligodendrocyte Lineage Cells Determines Response to Demyelination and Susceptibility to Age-Associated Functional Decline (2016)
Journal Article
Crawford, A. H., Tripathi, R. B., Richardson, W. D., & Franklin, R. J. M. (2016). Developmental Origin of Oligodendrocyte Lineage Cells Determines Response to Demyelination and Susceptibility to Age-Associated Functional Decline. Cell Reports, 15(4), 761-773. https://doi.org/10.1016/j.celrep.2016.03.069

Oligodendrocyte progenitors (OPs) arise from distinct ventral and dorsal domains within the ventricular germinal zones of the embryonic CNS. The functional significance, if any, of these different populations is not known. Using dual-color reporter m... Read More about Developmental Origin of Oligodendrocyte Lineage Cells Determines Response to Demyelination and Susceptibility to Age-Associated Functional Decline.

Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination (2015)
Journal Article
Natrajan, M. S., De La Fuente, A. G., Crawford, A. H., Lineham, E., Nuñez, V., Johnson, K. R., …Franklin, R. J. (2015). Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination. Brain, 138(Pt12), 3581-97. https://doi.org/10.1093/brain/awv289

The efficiency of central nervous system remyelination declines with age. This is in part due to an age-associated decline in the phagocytic removal of myelin debris, which contains inhibitors of oligodendrocyte progenitor cell differentiation. In th... Read More about Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination.

Oligodendrocyte progenitors: adult stem cells of the central nervous system (2014)
Journal Article
Crawford, A. H., Stockley, J. H., Tripathi, R. B., Richardson, W. D., & Franklin, R. J. (2014). Oligodendrocyte progenitors: adult stem cells of the central nervous system. Experimental Neurology, 260, 50-5. https://doi.org/10.1016/j.expneurol.2014.04.027

Oligodendrocyte progenitors (OPs) are a major proliferating cell population within the adult CNS. In response to myelin loss or increasing demand, OPs have the capacity to differentiate into mature, myelinating oligodendrocytes. The name ‘oligodendro... Read More about Oligodendrocyte progenitors: adult stem cells of the central nervous system.