Aging enhances a mechanically-induced reduction in tendon strength by an active process involving matrix metalloproteinase activity
Journal Article
Dudhia, J., Scott, C. M., Draper, E. R. C., Heinegard, D., Pitsillides, A. A., & Smith, R. K. W. Aging enhances a mechanically-induced reduction in tendon strength by an active process involving matrix metalloproteinase activity. Aging Cell, 6(4), 547-556. https://doi.org/10.1111/j.1474-9726.2007.00307.x
Outputs (136)
Cell phenotypic variation in normal and damaged tendons
Presentation / Conference Contribution
Clegg, P. D., Strassburg, S., & Smith, R. K. W. Cell phenotypic variation in normal and damaged tendons. https://doi.org/10.1111/j.1365-2613.2007.00549.x
The effect of early training and the adaptation and conditioning of skeletal tissues
Journal Article
Smith, R. K. W., & Goodship, A. E. The effect of early training and the adaptation and conditioning of skeletal tissues. https://doi.org/10.1016/j.cveq.2007.11.005Horses as equine athletes must be conditioned and trained to optimize the whole animal for the particular type of athletic activity. An extremely high proportion of all injuries in the equine athlete in general, and in the racehorse in particular, ar... Read More about The effect of early training and the adaptation and conditioning of skeletal tissues.
Tendon and ligament physiology: responses to exercise and training
Book Chapter
Smith, R. K. W., & Goodship, A. E. Tendon and ligament physiology: responses to exercise and training.
Size isn't everything: The importance of the hindlimb accessory ligament of the deep digital flexor tendon
Journal Article
Smith, R. K. W., & Eliashar, E. Size isn't everything: The importance of the hindlimb accessory ligament of the deep digital flexor tendon. Equine Veterinary Education, 20(12), 625-626. https://doi.org/10.2746/095777308x387655
THE INFLUENCE OF AGEING IN TENDON HOMEOSTASIS AND THE RISK OF TENDON INJURY
Presentation / Conference Contribution
Smith, R. K. W., Dudhia, J., Scott, C. M., Draper, E., May, S. A., & Pitsillides, A. A. THE INFLUENCE OF AGEING IN TENDON HOMEOSTASIS AND THE RISK OF TENDON INJURY. International Journal of Experimental Pathology, 89(3), A25-A25
Mesenchymal stem cell therapy for equine tendinopathy
Journal Article
Smith, R. K. W. Mesenchymal stem cell therapy for equine tendinopathy. Disability and Rehabilitation, 30(20-22), 1752-1758. https://doi.org/10.1080/09638280701788241Optimal management of tendon overuse injuries in equine and human athletes should avoid the formation of excessive scar tissue, regenerate normal tendon matrix, and reduce re-injury rates. We hypothesized that the implantation of marrow-derived strom... Read More about Mesenchymal stem cell therapy for equine tendinopathy.
Principles of stem cell therapy in the horse - the science behind the technology
Journal Article
Smith, R. K. W. Principles of stem cell therapy in the horse - the science behind the technologyTendon and ligament overstrain injuries in the horse are appropriate diseases to consider for stem cell therapy because normal fibrous repair results in reduced functionality, typified by poorer performance and a high rate of re-injury. Exogenously a... Read More about Principles of stem cell therapy in the horse - the science behind the technology.
Stem cell therapy for tendon and ligament injuries in the horse - technique and outcome
Journal Article
Smith, R. K. W. Stem cell therapy for tendon and ligament injuries in the horse - technique and outcomeThe technique involves the collection of bone marrow from the sternum in the standing sedated horse, followed by isolation and expansion of the nucleated adherent cell population (containing the MSCs) in the laboratory. After approximately 2-3 weeks,... Read More about Stem cell therapy for tendon and ligament injuries in the horse - technique and outcome.
Intratendinous treatments - are they innocuous?
Journal Article
Smith, R. K. W. Intratendinous treatments - are they innocuous?. Equine Veterinary Education, 20(7), 392-392. https://doi.org/10.2746/095777308x331548