Outputs (136)

One health in regenerative medicine: report on the second Havemeyer symposium on regenerative medicine in horses (2020)
Journal Article
Fortier, L. A., Goodrich, L. R., Ribitsch, I., Schnabel, L. V., Shepard, D. O., Watts, A. E., & Whealands Smith, R. K. (2020). One health in regenerative medicine: report on the second Havemeyer symposium on regenerative medicine in horses. Regenerative Medicine, 15(6), 1775-1787. https://doi.org/10.2217/rme-2019-0143

Regenerative medicine is commonly used in human and equine athletes. Potential therapies include culture expanded stem cells, stromal vascular fraction of adipose tissue, platelet-rich plasma, bone marrow concentrate, or autologous conditioned serum.... Read More about One health in regenerative medicine: report on the second Havemeyer symposium on regenerative medicine in horses.

Acute life-threatening laryngeal dysfunction in a draft horse recovering from general anesthesia: a case report (2020)
Journal Article
Ronaldson, H. L., Monticelli, P., Smith, R. K. W., & Adami, C. (2020). Acute life-threatening laryngeal dysfunction in a draft horse recovering from general anesthesia: a case report. Journal of Equine Veterinary Science, 103109. https://doi.org/10.1016/j.jevs.2020.103109

A 13-year-old Shire horse was anesthetized for an elective orthopaedic procedure. During recovery from anesthesia, the occurrence of severe acute dyspnea required a second anesthetic to allow endoscopy-guided nasotracheal intubation. Endoscopic findi... Read More about Acute life-threatening laryngeal dysfunction in a draft horse recovering from general anesthesia: a case report.

Development of a Cartilage Oligomeric Matrix Protein Neo-Epitope Assay for the Detection of Intra-Thecal Tendon Disease (2020)
Journal Article
Smith, R. K. W., Önnerfjord, P., Holmgren, K., di Grado, S., & Dudhia, J. (2020). Development of a Cartilage Oligomeric Matrix Protein Neo-Epitope Assay for the Detection of Intra-Thecal Tendon Disease. International Journal of Molecular Sciences, 21(6), 2155. https://doi.org/10.3390/ijms21062155

The diagnosis of tendon injury relies on clinical signs and diagnostic imaging but imaging is subjective and does not always correlate with clinical signs. A molecular marker would potentially offer a sensitive and specific diagnostic tool that could... Read More about Development of a Cartilage Oligomeric Matrix Protein Neo-Epitope Assay for the Detection of Intra-Thecal Tendon Disease.

Histopathological and immunohistochemical evaluation of cellular response to a woven and electrospun polydioxanone (PDO) and polycaprolactone (PCL) patch for tendon repair (2020)
Journal Article
Rashid, M., Dudhia, J., Dakin, S. G., Snelling, S. J. B., De Godoy, R., Mouthuy, P., …Carr, A. J. (2020). Histopathological and immunohistochemical evaluation of cellular response to a woven and electrospun polydioxanone (PDO) and polycaprolactone (PCL) patch for tendon repair. Scientific Reports, 10(1), https://doi.org/10.1038/s41598-020-61725-5

We investigated endogenous tissue response to a woven and electrospun polydioxanone (PDO) and polycaprolactone (PCL) patch intended for tendon repair. A sheep tendon injury model characterised by a natural history of consistent failure of healing was... Read More about Histopathological and immunohistochemical evaluation of cellular response to a woven and electrospun polydioxanone (PDO) and polycaprolactone (PCL) patch for tendon repair.

Regenerative medicine in equine orthopaedics: what and when? (2020)
Journal Article
Smith, R. K. W. (2020). Regenerative medicine in equine orthopaedics: what and when?. https://doi.org/10.12968/ukve.2020.4.1.8

The development of regenerative medicine has opened up many new therapeutic avenues in veterinary medicine. The focus of regenerative medicine in the horse lies primarily in the musculoskeletal system, where the consequences of injury make tendons, l... Read More about Regenerative medicine in equine orthopaedics: what and when?.

Risk of intra-articular injection with longitudinal ultrasound-guided injection of the collateral ligaments of the distal interphalangeal joint in the horse (2019)
Journal Article
Smith, R. K. W., Parsons, J., & Dixon, J. J. (2019). Risk of intra-articular injection with longitudinal ultrasound-guided injection of the collateral ligaments of the distal interphalangeal joint in the horse. https://doi.org/10.1111/vru.12811

Desmopathy of the collateral ligaments of the distal interphalangeal joint is a common cause of equine foot lameness and carries a poor prognosis with conservative management. Intralesional injections may improve healing, although accuracy of radiogr... Read More about Risk of intra-articular injection with longitudinal ultrasound-guided injection of the collateral ligaments of the distal interphalangeal joint in the horse.

Improved diagnostic criteria for digital flexor tendon sheath pathology using contrast tenography (2019)
Journal Article
Kent, A. V., Chesworth, M. J., Wells, G., Gerdes, C., Bladon, B. M., Smith, R. K. W., & Fiske-Jackson, A. R. (2019). Improved diagnostic criteria for digital flexor tendon sheath pathology using contrast tenography. Equine Veterinary Journal, 52(2), 205-212. https://doi.org/10.1111/evj.13166

Evaluation of the Effects of Synovial Multipotent Cells on Deep Digital Flexor Tendon Repair in a Large Animal Model of Intra-Synovial Tendinopathy (2019)
Journal Article
Khan, M. R., Smith, R. K., David, F. H., Lam, R., Hughes, G., DeGodoy, R., …Dudhia, J. (2019). Evaluation of the Effects of Synovial Multipotent Cells on Deep Digital Flexor Tendon Repair in a Large Animal Model of Intra-Synovial Tendinopathy. Journal of Orthopaedic Research, 38(1), 128-138. https://doi.org/10.1002/jor.24423

ntra‐synovial tendon injuries are a common orthopedic problem with limited treatment options. The synovium is a specialized connective tissue forming the inner encapsulating lining of diarthrodial joints and intra‐synovial tendons. It contains multip... Read More about Evaluation of the Effects of Synovial Multipotent Cells on Deep Digital Flexor Tendon Repair in a Large Animal Model of Intra-Synovial Tendinopathy.

Ultrasonography of the stifle (2019)
Journal Article
Cauvin, E. R. J., & Smith, R. K. W. (2019). Ultrasonography of the stifle. https://doi.org/10.12968/ukve.2019.3.3.86

Stifle injuries are increasingly recognised as a major cause of hind limb lameness and commonly affect the soft tissues of the joint in adult horses, making ultrasonography a vital part of diagnostic imaging of this joint. This article aims to provid... Read More about Ultrasonography of the stifle.

Bone marrow mesenchymal stem cells do not enhance intra-synovial tendon healing despite engraftment and homing to niches within the synovium (2018)
Journal Article
Khan, M. R., Dudhia, J., David, F. H., De Godoy, R., Mehra, V., Hughes, G., …Smith, R. K. W. (2018). Bone marrow mesenchymal stem cells do not enhance intra-synovial tendon healing despite engraftment and homing to niches within the synovium. https://doi.org/10.1186/s13287-018-0900-7

Intra-synovial tendon injuries display poor healing, which often results in reduced functionality and pain. A lack of effective therapeutic options has led to experimental approaches to augment natural tendon repair with autologous mesenchymal stem c... Read More about Bone marrow mesenchymal stem cells do not enhance intra-synovial tendon healing despite engraftment and homing to niches within the synovium.