Bone marrow mesenchymal stem cells do not enhance intra-synovial tendon healing despite engraftment and homing to niches within the synovium

Khan, M R; Dudhia, J; David, F H; De Godoy, R; Mehra, V; Hughes, G; Dakin, S G; Carr, A J; Goodship, A E; Smith, R K W

Abstract

Intra-synovial tendon injuries display poor healing, which often results in reduced functionality and pain. A lack of effective therapeutic options has led to experimental approaches to augment natural tendon repair with autologous mesenchymal stem cells (MSCs) although the effects of the intra-synovial environment on the distribution, engraftment and functionality of implanted MSCs is not known. This study utilised a novel sheep model which, although in an anatomically different location, more accurately mimics the mechanical and synovial environment of the human rotator cuff, to determine the effects of intra-synovial implantation of MSCs.

Citation

Khan, M. R., Dudhia, J., David, F. H., De Godoy, R., Mehra, V., Hughes, G., Dakin, S. G., Carr, A. J., Goodship, A. E., & Smith, R. K. W. (2018). Bone marrow mesenchymal stem cells do not enhance intra-synovial tendon healing despite engraftment and homing to niches within the synovium. https://doi.org/10.1186/s13287-018-0900-7

• Journal Article Type: Article
• Acceptance Date: May 9, 2018
• Publication Date: Jun 19, 2018
• Deposit Date: Jun 21, 2018
• Publicly Available Date: Jun 25, 2018
• Journal: Stem Cell Research & Therapy
• Peer Reviewed: Peer Reviewed
• Volume: 9
• Issue: 169
• DOI: https://doi.org/10.1186/s13287-018-0900-7
• Public URL: https://rvc-repository.worktribe.com/output/1386845