Bone marrow mesenchymal stem cells do not enhance intra-synovial tendon healing despite engraftment and homing to niches within the synovium

Khan, M R; Dudhia, J; David, F H; De Godoy, R; Mehra, V; Hughes, G; Dakin, S G; Carr, A J; Goodship, A E; Smith, R K W

Abstract

Intra-synovial tendon injuries display poor healing, which often results in reduced functionality and pain. A lack of effective therapeutic options has led to experimental approaches to augment natural tendon repair with autologous mesenchymal stem cells (MSCs) although the effects of the intra-synovial environment on the distribution, engraftment and functionality of implanted MSCs is not known. This study utilised a novel sheep model which, although in an anatomically different location, more accurately mimics the mechanical and synovial environment of the human rotator cuff, to determine the effects of intra-synovial implantation of MSCs.

Citation

Khan, M. R., Dudhia, J., David, F. H., De Godoy, R., Mehra, V., Hughes, G., …Smith, R. K. W. (2018). Bone marrow mesenchymal stem cells do not enhance intra-synovial tendon healing despite engraftment and homing to niches within the synovium. https://doi.org/10.1186/s13287-018-0900-7

• Journal Article Type: Article
• Acceptance Date: May 9, 2018
• Publication Date: Jun 19, 2018
• Deposit Date: Jun 21, 2018
• Publicly Available Date: Nov 21, 2020
• Journal: Stem Cell Research & Therapy
• Peer Reviewed: Peer Reviewed
• Volume: 9
• Issue: 169
• DOI: https://doi.org/10.1186/s13287-018-0900-7
• Public URL: https://rvc-repository.worktribe.com/output/1386845