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Comparison of cellular assays for TLR activation and development of a species-specific reporter cell line for cattle (2017)
Journal Article
Tombacz, K., Mwangi, D., Werling, D., & Gibson, A. J. (2017). Comparison of cellular assays for TLR activation and development of a species-specific reporter cell line for cattle. Innate Immunity, 23(4), 329-335. https://doi.org/10.1177/1753425917695445

PRRs are sentinels of the innate immune system, with TLRs being the most important. Assays for TLR ligand interactions have been used to gain insights into their function and signaling pathways. As significant differences exist between species with r... Read More about Comparison of cellular assays for TLR activation and development of a species-specific reporter cell line for cattle.

Development and initial validation of a sensory threshold examination protocol (STEP) for phenotyping canine pain syndromes (2017)
Journal Article
Sanchis-Mora, S., Chang, Y. M., Abeyesinghe, S. M., Fisher, A., Volk, H. A., & Pelligand, L. (2017). Development and initial validation of a sensory threshold examination protocol (STEP) for phenotyping canine pain syndromes. Veterinary Anaesthesia and Analgesia, 44(3), 600-614. https://doi.org/10.1016/j.vaa.2016.09.004

Objective To study feasibility and test-retest repeatability of a sensory threshold examination protocol (STEP) and report quantitative sensory threshold distributions in healthy dogs. Study design Prospective, observational, cohort study.... Read More about Development and initial validation of a sensory threshold examination protocol (STEP) for phenotyping canine pain syndromes.

Cephem Potentiation by Inactivation of Nonessential Genes Involved in Cell Wall Biogenesis of ß-Lactamase-Producing Escherichia coli (2017)
Journal Article
Baker, K. R., Sigurðardóttir, H. H., Jana, B., & Guardabassi, L. (2017). Cephem Potentiation by Inactivation of Nonessential Genes Involved in Cell Wall Biogenesis of ß-Lactamase-Producing Escherichia coli. Antimicrobial Agents and Chemotherapy, 61(3), e01773-16. https://doi.org/10.1128/AAC.01773-16

Reversal of antimicrobial resistance is an appealing and largely unexplored strategy in drug discovery. The objective of this study was to identify potential targets for “helper” drugs reversing cephem resistance in Escherichia coli strains producing... Read More about Cephem Potentiation by Inactivation of Nonessential Genes Involved in Cell Wall Biogenesis of ß-Lactamase-Producing Escherichia coli.

The secondary resistome of multidrug-resistant Klebsiella pneumoniae (2017)
Journal Article
Jana, B., Cain, A. K., Doerrler, W. T., Boinett, C. J., Fookes, M. C., Parkhill, J., & Guardabassi, L. (2017). The secondary resistome of multidrug-resistant Klebsiella pneumoniae. https://doi.org/10.1038/srep42483

Klebsiella pneumoniae causes severe lung and bloodstream infections that are difficult to treat due to multidrug resistance. We hypothesized that antimicrobial resistance can be reversed by targeting chromosomal non-essential genes that are not respo... Read More about The secondary resistome of multidrug-resistant Klebsiella pneumoniae.