Outputs (65)

A role for B lymphocytes in anti-infective prion therapies?
Journal Article
Tayebi, M., Bate, C., Hawke, S., & Williams, A. A role for B lymphocytes in anti-infective prion therapies?. Expert Review of Anti-infective Therapy, 5(4), 631-638. https://doi.org/10.1586/14787210.5.4.631

Squalestatin alters the intracellular trafficking of a neurotoxic prion peptide
Journal Article
Wilson, R., Bate, C., Boshuizen, R., Williams, A., & Brewer, J. Squalestatin alters the intracellular trafficking of a neurotoxic prion peptide. BMC Neuroscience, 8,

Background: Neurotoxic peptides derived from the protease-resistant core of the prion protein are used to model the pathogenesis of prion diseases. The current study characterised the ingestion, internalization and intracellular trafficking of a neur... Read More about Squalestatin alters the intracellular trafficking of a neurotoxic prion peptide.

Interferon-gamma increases neuronal death in response to amyloid-beta(1-42)
Journal Article
Bate, C., Kempster, S., Last, V., & Williams, A. Interferon-gamma increases neuronal death in response to amyloid-beta(1-42). https://doi.org/10.1186/1742-2094-3-7

Platelet-activating factor antagonists protect amyloid-beta damaged neurons from microglia-mediated death
Journal Article
Bate, C., Kempster, S., & Williams, A. Platelet-activating factor antagonists protect amyloid-beta damaged neurons from microglia-mediated death. Neuropharmacology, 51(2), 173-181. https://doi.org/10.1016/j.neuropharm.2006.02.015

Prostaglandin D-2 mediates neuronal damage by amyloid-beta or prions which activates microglial cells
Journal Article
Bate, C., Kempster, S., & Williams, A. Prostaglandin D-2 mediates neuronal damage by amyloid-beta or prions which activates microglial cells. Neuropharmacology, 50(2), 229-237. https://doi.org/10.1016/j.neuropharm.2005.09.008

Microglial cells kill prion-damaged neurons in vitro by a CD14-dependent process
Journal Article
Bate, C., Boshuizen, R., & Williams, A. Microglial cells kill prion-damaged neurons in vitro by a CD14-dependent process. Journal of Neuroimmunology, 170(1-2), 62-70. https://doi.org/10.1016/j.jneuroim.2005.08.021

Manipulation of PrPres production in scrapie-infected neuroblastoma cells
Journal Article
Bate, C., Langeveld, J., & Williams, A. Manipulation of PrPres production in scrapie-infected neuroblastoma cells. Journal of Neuroscience Methods, 138(1-2), 217-223. https://doi.org/10.1016/j.jneumeth.2004.04.001

Phospholipase A(2) inhibitors or platelet-activating factor antagonists prevent prion replication
Journal Article
Bate, C., Reid, S. W. J., & Williams, A. Phospholipase A(2) inhibitors or platelet-activating factor antagonists prevent prion replication. Journal of Biological Chemistry, 279(35), 36405-36411. https://doi.org/10.1074/jbc.M404086200

Squalestatin cures prion-infected neurons and protects against prion neurotoxicity
Journal Article
Bate, C., Salmona, M., Diomede, L., & Williams, A. Squalestatin cures prion-infected neurons and protects against prion neurotoxicity. Journal of Biological Chemistry, 279(15), 14983-14990. https://doi.org/10.1074/jbc.M313061200

The role of platelet activating factor in prion and amyloid-beta neurotoxicity
Journal Article
Bate, C., Salmona, M., & Williams, A. The role of platelet activating factor in prion and amyloid-beta neurotoxicity. NeuroReport, 15(3), 509-513. https://doi.org/10.1097/01.wnr.0000113065.17279.7b