Squalestatin alters the intracellular trafficking of a neurotoxic prion peptide

Wilson, R; Bate, C; Boshuizen, R; Williams, A; Brewer, J

Squalestatin alters the intracellular trafficking of a neurotoxic prion peptide

Wilson, R; Bate, C; Boshuizen, R; Williams, A; Brewer, J

Authors

R Wilson

C Bate

R Boshuizen

A Williams

J Brewer

Abstract

Background: Neurotoxic peptides derived from the protease-resistant core of the prion protein are used to model the pathogenesis of prion diseases. The current study characterised the ingestion, internalization and intracellular trafficking of a neurotoxic peptide containing amino acids 105-132 of the murine prion protein (MoPrP105-132) in neuroblastoma cells and primary cortical neurons.

Citation

Wilson, R., Bate, C., Boshuizen, R., Williams, A., & Brewer, J. Squalestatin alters the intracellular trafficking of a neurotoxic prion peptide. BMC Neuroscience, 8,

Journal Article Type	Article
Deposit Date	Nov 11, 2014
Journal	Bmc Neuroscience
Publisher	BioMed Central
Volume	8
Public URL	https://rvc-repository.worktribe.com/output/1433244
Additional Information	Corporate Creators : Glasgow, Pepscan Syst BV, Strathclyde