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Outputs (150)

Potential of milk mid-IR spectra to predict metabolic status of cows through blood components and an innovative clustering approach (2019)
Journal Article
Grelet, C., Vanlierde, A., Hostens, M., Foldager, L., Salavati, M., Ingvartsen, K. L., …GplusE Consortium, . (2019). Potential of milk mid-IR spectra to predict metabolic status of cows through blood components and an innovative clustering approach. animal, 13(3), 649-658. https://doi.org/10.1017/S1751731118001751

Unbalanced metabolic status in the weeks after calving predisposes dairy cows to metabolic and infectious diseases. Blood glucose, IGF-I, non-esterified fatty acids (NEFA) and β-hydroxybutyrate (BHB) are used as indicators of the metabolic status of... Read More about Potential of milk mid-IR spectra to predict metabolic status of cows through blood components and an innovative clustering approach.

Toxoplasma gondii profilin does not stimulate an innate immune response through bovine or human TLR5 (2018)
Journal Article
Tombacz, K., Burgess, G., Holder, A. L., Werners, A., & Werling, D. (2018). Toxoplasma gondii profilin does not stimulate an innate immune response through bovine or human TLR5. Innate Immunity, https://doi.org/10.1177/1753425918798450

Toxoplasma gondii is responsible for one of the most prevalent infections in people. T. gondii profilin (TgPr) is a protein integral to parasite movement and cellular invasion. Murine TLR has been described to bind TgPr. Furthermore, more recently, h... Read More about Toxoplasma gondii profilin does not stimulate an innate immune response through bovine or human TLR5.

Genome-wide association studies of inflammatory bowel disease in German shepherd dogs (2018)
Journal Article
Perivan, A., Bertolini, F., Rothschild, M. F., Simpson, K. W., Jergens, A. E., Allenspach, K., & Werling, D. (2018). Genome-wide association studies of inflammatory bowel disease in German shepherd dogs. PLoS ONE, 13(7), e0200685. https://doi.org/10.1371/journal.pone.0200685

Canine Inflammatory Bowel Disease (IBD) is considered a multifactorial disease caused by complex interactions between the intestinal immune system, intestinal microbiota and environmental factors in genetically susceptible individuals. Although IBD c... Read More about Genome-wide association studies of inflammatory bowel disease in German shepherd dogs.

Characterisation of porcine circovirus type 2 in porcine circovirus disease cases in England and Wales (2018)
Journal Article
Grierson, S. S., Werling, D., Bidewell, C., & Williamson, S. (2018). Characterisation of porcine circovirus type 2 in porcine circovirus disease cases in England and Wales. Veterinary Record, 182(1), 22. https://doi.org/10.1136/vr.104450

Confirmed cases of porcine circovirus disease (PCVD) in Great Britain have shown a steady decline since the availability of porcine circovirus type 2 (PCV2) vaccines. However, PCVD is still occasionally diagnosed. The authors carried out a genotyping... Read More about Characterisation of porcine circovirus type 2 in porcine circovirus disease cases in England and Wales.

Polymorphisms in the selectin gene cluster are associated with fertility and survival time in a population of Holstein Friesian cows (2017)
Journal Article
Chen, X., Zhang, S., Cheng, Z. R., Cooke, J. S., Werling, D., Wathes, D. C., & Pollott, G. E. (2017). Polymorphisms in the selectin gene cluster are associated with fertility and survival time in a population of Holstein Friesian cows. PLoS ONE, 12(4), https://doi.org/10.1371/journal.pone.0175555

Selectins are adhesion molecules, which mediate attachment between leucocytes and endothelium. They aid extravasation of leucocytes from blood into inflamed tissue during the mammary gland’s response to infection. Selectins are also involved in attac... Read More about Polymorphisms in the selectin gene cluster are associated with fertility and survival time in a population of Holstein Friesian cows.

Comparison of cellular assays for TLR activation and development of a species-specific reporter cell line for cattle (2017)
Journal Article
Tombacz, K., Mwangi, D., Werling, D., & Gibson, A. J. (2017). Comparison of cellular assays for TLR activation and development of a species-specific reporter cell line for cattle. Innate Immunity, 23(4), 329-335. https://doi.org/10.1177/1753425917695445

PRRs are sentinels of the innate immune system, with TLRs being the most important. Assays for TLR ligand interactions have been used to gain insights into their function and signaling pathways. As significant differences exist between species with r... Read More about Comparison of cellular assays for TLR activation and development of a species-specific reporter cell line for cattle.