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The Structure and Unusual Protein Chemistry of Hypoxic Response Protein 1, a Latency Antigen and Highly Expressed Member of the DosR Regulon in Mycobacterium tuberculosis (2008)
Journal Article
Sharpe, M. L., Gao, C., Kendall, S. L., Baker, E. N., & Lott, J. S. (2008). The Structure and Unusual Protein Chemistry of Hypoxic Response Protein 1, a Latency Antigen and Highly Expressed Member of the DosR Regulon in Mycobacterium tuberculosis. Journal of Molecular Biology, 383(4), 822-836. https://doi.org/10.1016/j.jmb.2008.07.001

Mycobacterium tuberculosis adapts to cellular stresses such as decreased oxygen concentration, at least in part, by upregulation of the dormancy survival regulon, which is thought to be important for the bacterium's ability to enter a persistent stat... Read More about The Structure and Unusual Protein Chemistry of Hypoxic Response Protein 1, a Latency Antigen and Highly Expressed Member of the DosR Regulon in Mycobacterium tuberculosis.

Mycobacterium tuberculosis strains disrupted in mce3 and mce4 operons are attenuated in mice (2008)
Journal Article
Senaratne, R. H., Sidders, B., Sequeira, P., Saunders, G., Dunphy, K., Marjanovic, C., …Riley, L. W. (2008). Mycobacterium tuberculosis strains disrupted in mce3 and mce4 operons are attenuated in mice. Journal of Medical Microbiology, 57(2), 164-170. https://doi.org/10.1099/jmm.0.47454-0

The Mycobacterium tuberculosis genome contains four copies of an operon called mce (mce1-4). Previously we reported that M. tuberculosis disrupted in the mce1 operon is more virulent than wild-type M. tuberculosis in mice. We generated single deletio... Read More about Mycobacterium tuberculosis strains disrupted in mce3 and mce4 operons are attenuated in mice.

Quantification of global transcription patterns in prokaryotes using spotted microarrays (2007)
Journal Article
Sidders, B., Withers, M., Kendall, S. L., Bacon, J., Waddell, S. J., Hinds, J., …Stoker, N. G. (2007). Quantification of global transcription patterns in prokaryotes using spotted microarrays. Genome Biology, 8(12), R265. https://doi.org/10.1186/gb-2007-8-12-r265

We describe an analysis, applicable to any spotted microarray dataset produced using genomic DNA as a reference, that quantifies prokaryotic levels of mRNA on a genome-wide scale. Applying this to Mycobacterium tuberculosis, we validate the technique... Read More about Quantification of global transcription patterns in prokaryotes using spotted microarrays.

Mycobacterial cells have dual nickel-cobalt sensors - Sequence relationships and metal sites of metal-responsive repressors are not congruent (2007)
Journal Article
Campbell, D. R., Chapman, K. E., Waldron, K. J., Tottey, S., Kendall, S. L., Cavallaro, G., …Cavet, J. S. (2007). Mycobacterial cells have dual nickel-cobalt sensors - Sequence relationships and metal sites of metal-responsive repressors are not congruent. Journal of Biological Chemistry, 282(44), 32298-310. https://doi.org/10.1074/jbc.M703451200