Pathobiology and Population Sciences

Urinary and faecal N-methylhistamine concentrations do not serve as markers for mast cell activation or clinical disease activity in dogs with chronic enteropathies (2014)
Journal Article
Anfinsen, K. P., Berghoff, N., Priestnall, S. L., Suchodolski, J. S., Steiner, J. M., & Allenspach, K. (2014). Urinary and faecal N-methylhistamine concentrations do not serve as markers for mast cell activation or clinical disease activity in dogs with chronic enteropathies. Acta Veterinaria Scandinavica, 56(90), https://doi.org/10.1186/s13028-014-0090-y

This study sought to correlate faecal and urinary N-methylhistamine (NMH) concentrations with resting versus degranulated duodenal mast cell numbers in dogs with chronic enteropathies (CE), and investigate correlations between intestinal mast cell ac... Read More about Urinary and faecal N-methylhistamine concentrations do not serve as markers for mast cell activation or clinical disease activity in dogs with chronic enteropathies.

Two TIR-like domain containing proteins in a newly emerging zoonotic Staphylococcus aureus strain sequence type 398 are potential virulence factors by impacting on the host innate immune response (2014)
Journal Article
Patterson, N. J., Günther, J., Gibson, A. J., Offord, V., Coffey, T. J., Splitter, G., …Werling, D. (2014). Two TIR-like domain containing proteins in a newly emerging zoonotic Staphylococcus aureus strain sequence type 398 are potential virulence factors by impacting on the host innate immune response. Frontiers in Microbiology, 5(662), https://doi.org/10.3389/fmicb.2014.00662

Staphylococcus aureus, sequence type (ST) 398, is an emerging pathogen and the leading cause of livestock-associated methicillin-resistant S. aureus infections in Europe and North America. This strain is characterized by high promiscuity in terms of... Read More about Two TIR-like domain containing proteins in a newly emerging zoonotic Staphylococcus aureus strain sequence type 398 are potential virulence factors by impacting on the host innate immune response.

Purification, crystallization and preliminary X-ray crystallographic studies of KstR2 (keto-steroid regulatory protein) from Mycobacterium tuberculosis (2014)
Journal Article
Dawes, S. S., Kendall, S. L., Baker, E. N., & Lott, J. S. (2014). Purification, crystallization and preliminary X-ray crystallographic studies of KstR2 (keto-steroid regulatory protein) from Mycobacterium tuberculosis. https://doi.org/10.1107/S2053230X14023589

Recombinant canine single chain insulin analogues: Insulin receptor binding capacity and ability to stimulate glucose uptake (2014)
Journal Article
Adams, J. P., Holder, A. L., & Catchpole, B. (2014). Recombinant canine single chain insulin analogues: Insulin receptor binding capacity and ability to stimulate glucose uptake. https://doi.org/10.1016/j.tvjl.2014.09.027

Virtually all diabetic dogs require exogenous insulin therapy to control their hyperglycaemia. In the UK, the only licensed insulin product currently available is a purified porcine insulin preparation. Recombinant insulin is somewhat problematic in... Read More about Recombinant canine single chain insulin analogues: Insulin receptor binding capacity and ability to stimulate glucose uptake.

Influenza at the animal–human interface: a review of the literature for virological evidence of human infection with swine or avian influenza viruses other than A(H5N1) (2014)
Journal Article
Freidl, G. S., Meijer, A., De Bruin, E., De Nardi, M., Munoz, O., Capua, I., …FLURISK Consortium. (2014). Influenza at the animal–human interface: a review of the literature for virological evidence of human infection with swine or avian influenza viruses other than A(H5N1). Eurosurveillance, 19(18),

Factors that trigger human infection with animal influenza virus progressing into a pandemic are poorly understood. Within a project developing an evidence-based risk assessment framework for influenza viruses in animals, we conducted a review of the... Read More about Influenza at the animal–human interface: a review of the literature for virological evidence of human infection with swine or avian influenza viruses other than A(H5N1).

Application of integrated production and economic models to estimate the impact of Schmallenberg virus for various sheep production types in the UK and France (2014)
Journal Article
Alarcon, P., Haesler, B., Raboisson, D., Waret-Szkuta, A., Corbiere, F., & Rushton, J. (2014). Application of integrated production and economic models to estimate the impact of Schmallenberg virus for various sheep production types in the UK and France. Veterinary Record, 1(1), e000036-e000036. https://doi.org/10.1136/vetreco-2014-000036

The present study aimed to estimate and compare the economic impact of Schmallenberg virus (SBV) in different sheep production holdings using partial budget and gross margin analyses in combination with production models. The sheep production types... Read More about Application of integrated production and economic models to estimate the impact of Schmallenberg virus for various sheep production types in the UK and France.

The Generation of Successive Unmarked Mutations and Chromosomal Insertion of Heterologous Genes in Actinobacillus pleuropneumoniae Using Natural Transformation (2014)
Journal Article
Bossé, J. T., Soares-Bazzolli, D. M., Li, Y., Wren, B. W., Tucker, A. W., Maskell, D. J., …BRaDP1T Consortium, . (2014). The Generation of Successive Unmarked Mutations and Chromosomal Insertion of Heterologous Genes in Actinobacillus pleuropneumoniae Using Natural Transformation. PLoS ONE, 9(11), https://doi.org/10.1371/journal.pone.0111252

We have developed a simple method of generating scarless, unmarked mutations in Actinobacillus pleuropneumoniae by exploiting the ability of this bacterium to undergo natural transformation, and with no need to introduce plasmids encoding recombinase... Read More about The Generation of Successive Unmarked Mutations and Chromosomal Insertion of Heterologous Genes in Actinobacillus pleuropneumoniae Using Natural Transformation.

Outputs (73)