The influence of parathyroid hormone 1-34 on the osteogenic characteristics of adipose- and bone-marrow-derived mesenchymal stem cells from juvenile and ovarectomized rats

Osagie-Clouard, L; Sanghani-Kerai, A; Coathup, M; Meeson, R; Briggs, T; Blunn, G

Abstract

Mesenchymal stem cells (MSCs) are of growing interest in terms of bone regeneration. Most preclinical trials utilize bone-marrow-derived mesenchymal stem cells (bMSCs), although this is not without isolation and expansion difficulties. The aim of this study was: to compare the characteristics of bMSCs and adipose-derived mesenchymal stem cells (AdMSCs) from juvenile, adult, and ovarectomized (OVX) rats; and to assess the effect of human parathyroid hormone (hPTH) 1-34 on their osteogenic potential and migration to stromal cell-derived factor-1 (SDF-1).

Citation

Osagie-Clouard, L., Sanghani-Kerai, A., Coathup, M., Meeson, R., Briggs, T., & Blunn, G. (2019). The influence of parathyroid hormone 1-34 on the osteogenic characteristics of adipose- and bone-marrow-derived mesenchymal stem cells from juvenile and ovarectomized rats. https://doi.org/10.1302/2046-3758.88.BJR-2019-0018.R1

• Journal Article Type: Article
• Acceptance Date: Aug 2, 2019
• Publication Date: Aug 23, 2019
• Deposit Date: Mar 4, 2020
• Publicly Available Date: Mar 4, 2020
• Journal: Bone and Joint Research
• Peer Reviewed: Peer Reviewed
• Volume: 8
• Issue: 8
• Pages: 397-404
• DOI: https://doi.org/10.1302/2046-3758.88.BJR-2019-0018.R1
• Public URL: https://rvc-repository.worktribe.com/output/1380785