Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation

Martinez, M; Gehring, R; Mochel, J P; Pade, D; Pelligand, L

Abstract

During the 2017 Biennial meeting, the American Academy of Veterinary Pharmacology and Therapeutics hosted a 1?day session on the influence of population variability on dose?exposure?response relationships. In Part I, we highlighted some of the sources of population variability. Part II provides a summary of discussions on modelling and simulation tools that utilize existing pharmacokinetic data, can integrate drug physicochemical characteristics with species physiological characteristics and dosing information or that combine observed with predicted and in vitro information to explore and describe sources of variability that may influence the safe and effective use of veterinary pharmaceuticals.

Citation

Martinez, M., Gehring, R., Mochel, J. P., Pade, D., & Pelligand, L. (2018). Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation. Journal of Veterinary Pharmacology and Therapeutics, 41(4), E-68. https://doi.org/10.1111/jvp.12666

• Journal Article Type: Article
• Acceptance Date: Apr 15, 2018
• Publication Date: May 28, 2018
• Deposit Date: Jul 24, 2018
• Publicly Available Date: Nov 21, 2020
• Journal: JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
• Print ISSN: 0140-7783
• Publisher: American Academy of Veterinary Pharmacology and Therapeutics
• Peer Reviewed: Peer Reviewed
• Volume: 41
• Issue: 4
• Pages: E-68
• DOI: https://doi.org/10.1111/jvp.12666
• Public URL: https://rvc-repository.worktribe.com/output/1387096