Vesicular dysfunction and pathways to neurodegeneration

Lewis, Patrick A.

Abstract

Cellular control of vesicle biology and trafficking is critical for cell viability, with disruption of these pathways within the cells of the central nervous system resulting in neurodegeneration and disease. The past two decades have provided important insights into both the genetic and biological links between vesicle trafficking and neurodegeneration. In this essay, the pathways that have emerged as being critical for neuronal survival in the human brain will be discussed – illustrating the diversity of proteins and cellular events with three molecular case studies drawn from different neurological diseases.

Citation

Lewis, P. (2021). Vesicular dysfunction and pathways to neurodegeneration. Essays in Biochemistry, 65(7), 941-948. https://doi.org/10.1042/ebc20210034

• Journal Article Type: Article
• Acceptance Date: Nov 11, 2021
• Online Publication Date: Dec 22, 2021
• Publication Date: Dec 22, 2021
• Deposit Date: Feb 14, 2022
• Publicly Available Date: Feb 14, 2022
• Journal: Essays in Biochemistry
• Print ISSN: 0071-1365
• Electronic ISSN: 1744-1358
• Publisher: Portland Press
• Peer Reviewed: Peer Reviewed
• Volume: 65
• Issue: 7
• Pages: 941-948
• DOI: https://doi.org/10.1042/ebc20210034
• Keywords: Molecular Biology; Biochemistry
• Public URL: https://rvc-repository.worktribe.com/output/1557466