Skip to main content

Research Repository

Advanced Search

All Outputs (192)

Cartilage oligomeric matrix protein and hyaluronan levels in synovial fluid from horses with osteoarthritis of the tarsometatarsal joint compared to a control population
Journal Article
Taylor, S. E., Weaver, M. P., Pitsillides, A. A., Wheeler, B. T., Wheeler-Jones, C. P. D., Shaw, D. J., & Smith, R. K. W. Cartilage oligomeric matrix protein and hyaluronan levels in synovial fluid from horses with osteoarthritis of the tarsometatarsal joint compared to a control population. Equine Veterinary Journal, 38(6), 502-507. https://doi.org/10.2746/042516406X156073

Selective activation of the MEK-ERK pathway is regulated by mechanical stimuli in forming joints and promotes pericellular matrix formation
Journal Article
Bastow, E. R., Lamb, K. J., Lewthwaite, J. C., Osborne, A. C., Kavanagh, E., Wheeler-Jones, C. P. D., & Pitsillides, A. A. Selective activation of the MEK-ERK pathway is regulated by mechanical stimuli in forming joints and promotes pericellular matrix formation. Journal of Biological Chemistry, 280(12), 11749-11758. https://doi.org/10.1074/jbc.M414495200

Non-invasive axial loading of mouse tibiae increases cortical bone fori-nation and modifies trabecular organization: A new model to study cortical and cancellous compartments in a single loaded element
Journal Article
De Souza, R. L., Matsuura, M., Eckstein, F., Rawlinson, S. C. F., Lanyon, L. E., & Pitsillides, A. A. Non-invasive axial loading of mouse tibiae increases cortical bone fori-nation and modifies trabecular organization: A new model to study cortical and cancellous compartments in a single loaded element. BONE, 37(6), 810-818. https://doi.org/10.1016/j.bone.2005.07.022

Highly homologous Mycobacterium tuberculosis chaperonin 60 proteins with differential CD14 dependencies stimulate cytokine production by human monocytes through cooperative activation of p38 and ERK1/2 mitogen-activated protein kinases
Journal Article
Lewthwaite, J. C., Clarkin, C. E., Coates, A. R. M., Poole, S., Lawrence, R. A., Wheeler-Jones, C. P. D., …Henderson, B. Highly homologous Mycobacterium tuberculosis chaperonin 60 proteins with differential CD14 dependencies stimulate cytokine production by human monocytes through cooperative activation of p38 and ERK1/2 mitogen-activated protein kinases. International Immunopharmacology, 7(2), 230-240. https://doi.org/10.1016/j.intimp.2006.10.005

Identifying the cellular basis for reimplantation failure in repair of the rotator cuff
Journal Article
Simon, D. W. N., Clarkin, C. E., Das-Gupta, V., Rawlinson, S. C. F., Emery, R. J., & Pitsillides, A. A. Identifying the cellular basis for reimplantation failure in repair of the rotator cuff. https://doi.org/10.1302/0301-620x.90b5.20013

We examined cultured osteoblasts derived from paired samples from the greater tuberosity and acromion from eight patients with large chronic tears of the rotator cuff. We found that osteoblasts from the tuberosity had no apparent response to mechanic... Read More about Identifying the cellular basis for reimplantation failure in repair of the rotator cuff.

Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts
Journal Article
Chen, Y. L., Leask, A., Abraham, D. J., Pala, D., Xu, S. W., Khan, K., …Eastwood, M. Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts. Arthritis and Rheumatism, 58(2), 577-585. https://doi.org/10.1002/art.23146

Objective. To investigate the contribution of heparan sulfate proteoglycan and Ras/MEK/ERK to the overexpression of profibrotic proteins and the enhanced contractile ability of dermal fibroblasts from patients with systemic sclerosis (SSc; scleroderm... Read More about Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts.

Evaluation of VEGF-Mediated signaling in primary human cells reveals a paracrine action for VEGF in osteoblast-mediated crosstalk to endothelial cells
Journal Article
Clarkin, C. E., Emery, R. J., Pitsillides, A. A., & Wheeler-Jones, C. P. D. Evaluation of VEGF-Mediated signaling in primary human cells reveals a paracrine action for VEGF in osteoblast-mediated crosstalk to endothelial cells. Journal of Cellular Physiology, 214(2), 537-544. https://doi.org/10.1002/jcp.21234

Communication between endothelial and bone cells is crucial for controlling vascular supply during bone growth, remodeling, and repair but the molecular mechanisms coordinating this intercellular crosstalk remain ill-defined. We have used primary hum... Read More about Evaluation of VEGF-Mediated signaling in primary human cells reveals a paracrine action for VEGF in osteoblast-mediated crosstalk to endothelial cells.

Heterotypic contact reveals a COX-2-mediated suppression of osteoblast differentiation by endothelial cells: A negative modulatory role for prostanoids in VEGF-mediated cell: cell communication?
Journal Article
Clarkin, C. E., Garonna, E., Pitsillides, A. A., & Wheeler-Jones, C. P. D. Heterotypic contact reveals a COX-2-mediated suppression of osteoblast differentiation by endothelial cells: A negative modulatory role for prostanoids in VEGF-mediated cell: cell communication?. Experimental Cell Research, 314(17), 3152-3161. https://doi.org/10.1016/j.yexcr.2008.07.027

in bone, angiogenesis most be initiated appropriately, but limited once remodelling or repair is complete. Our recent findings have Supported a role for prostaglandins (PG), known modulators of osteoblast (OB) and endothelial cell (EC) behaviour, in... Read More about Heterotypic contact reveals a COX-2-mediated suppression of osteoblast differentiation by endothelial cells: A negative modulatory role for prostanoids in VEGF-mediated cell: cell communication?.