Early effects of embryonic movement: 'a shot out of the dark'
Conference Proceeding
Pitsillides, A. A. Early effects of embryonic movement: 'a shot out of the dark'. https://doi.org/10.1111/j.1469-7580.2006.00556.x
All Outputs (192)
Cartilage oligomeric matrix protein and hyaluronan levels in synovial fluid from horses with osteoarthritis of the tarsometatarsal joint compared to a control population
Journal Article
Taylor, S. E., Weaver, M. P., Pitsillides, A. A., Wheeler, B. T., Wheeler-Jones, C. P. D., Shaw, D. J., & Smith, R. K. W. Cartilage oligomeric matrix protein and hyaluronan levels in synovial fluid from horses with osteoarthritis of the tarsometatarsal joint compared to a control population. Equine Veterinary Journal, 38(6), 502-507. https://doi.org/10.2746/042516406X156073
Osteocytes use estrogen receptor alpha to respond to strain but their ER alpha content is regulated by estrogen
Journal Article
Zaman, G., Jessop, H. L., Muzylak, M., De Souza, R. L., Pitsillides, A. A., Price, J. S., & Lanyon, L. L. Osteocytes use estrogen receptor alpha to respond to strain but their ER alpha content is regulated by estrogen. Journal of Bone and Mineral Research, 21(8), 1297-1306. https://doi.org/10.1359/JBMR.060504
Selective activation of the MEK-ERK pathway is regulated by mechanical stimuli in forming joints and promotes pericellular matrix formation
Journal Article
Bastow, E. R., Lamb, K. J., Lewthwaite, J. C., Osborne, A. C., Kavanagh, E., Wheeler-Jones, C. P. D., & Pitsillides, A. A. Selective activation of the MEK-ERK pathway is regulated by mechanical stimuli in forming joints and promotes pericellular matrix formation. Journal of Biological Chemistry, 280(12), 11749-11758. https://doi.org/10.1074/jbc.M414495200
Osteocytic expression of constitutive NO synthase isoforms in the femoral neck cortex: A case-control study of intracapsular hip fracture
Journal Article
Caballero-Alias, A. M., Loveridge, N., Pitsillides, A. A., Parker, M., Kaptoge, S., Lyon, A., & Reeve, J. Osteocytic expression of constitutive NO synthase isoforms in the femoral neck cortex: A case-control study of intracapsular hip fracture. Journal of Bone and Mineral Research, 20(2), 268-273. https://doi.org/10.1359/JBMR.041103
Non-invasive axial loading of mouse tibiae increases cortical bone fori-nation and modifies trabecular organization: A new model to study cortical and cancellous compartments in a single loaded element
Journal Article
De Souza, R. L., Matsuura, M., Eckstein, F., Rawlinson, S. C. F., Lanyon, L. E., & Pitsillides, A. A. Non-invasive axial loading of mouse tibiae increases cortical bone fori-nation and modifies trabecular organization: A new model to study cortical and cancellous compartments in a single loaded element. BONE, 37(6), 810-818. https://doi.org/10.1016/j.bone.2005.07.022
Sympathetic nervous system does not mediate the load-induced cortical new bone formation
Journal Article
De Souza, R. L., Pitsillides, A. A., Lanyon, L. E., Skerry, T. M., & Chenu, C. Sympathetic nervous system does not mediate the load-induced cortical new bone formation. Journal of Bone and Mineral Research, 20(12), 2159-2168. https://doi.org/10.1359/JBMR.050812
NOS isoforms in adult human osteocytes: Multiple pathways of NO regulation?
Journal Article
Caballero-Alias, A. M., Loveridge, N., Lyon, A., Das-Gupta, V., Pitsillides, A. A., & Reeve, J. NOS isoforms in adult human osteocytes: Multiple pathways of NO regulation?. Calcified Tissue International, 75(1), 78-84. https://doi.org/10.1007/s00223-003-0161-y
Quantitative cytochemical evidence for local increases in bone turnover at the acromial enthesis of the human coracoacromial ligament
Journal Article
Chambler, A., Rawlinson, S. C. F., Emery, R., & Pitsillides, A. A. Quantitative cytochemical evidence for local increases in bone turnover at the acromial enthesis of the human coracoacromial ligament
Osteoblast-like cells from estrogen receptor alpha knockout mice have deficient responses to mechanical strain
Journal Article
Jessop, H. L., Suswillo, R. F. L., Rawlinson, S. C. F., Zaman, G., Lee, K. C. L., Das-Gupta, V., …Lanyon, L. E. Osteoblast-like cells from estrogen receptor alpha knockout mice have deficient responses to mechanical strain. Journal of Bone and Mineral Research, 19(6), 938-946
Acromial spur formation in patients with rotator cuff tears
Journal Article
Chambler, A. F. W., Pitsillides, A. A., & Emery, R. J. H. Acromial spur formation in patients with rotator cuff tears. Journal of Shoulder and Elbow Surgery, 12(4), 314-321. https://doi.org/10.1016/S1058-2746%2803%2900030-2
A mechanism underlying the movement requirement for synovial joint cavitation
Journal Article
Dowthwaite, G. P., Flannery, C. R., Flannelly, J., Lewthwaite, J. C., Archer, C. W., & Pitsillides, A. A. A mechanism underlying the movement requirement for synovial joint cavitation. Matrix Biology, 22(4), 311-322. https://doi.org/10.1016/S0945-053X%2803%2900037-4
Highly homologous Mycobacterium tuberculosis chaperonin 60 proteins with differential CD14 dependencies stimulate cytokine production by human monocytes through cooperative activation of p38 and ERK1/2 mitogen-activated protein kinases
Journal Article
Lewthwaite, J. C., Clarkin, C. E., Coates, A. R. M., Poole, S., Lawrence, R. A., Wheeler-Jones, C. P. D., …Henderson, B. Highly homologous Mycobacterium tuberculosis chaperonin 60 proteins with differential CD14 dependencies stimulate cytokine production by human monocytes through cooperative activation of p38 and ERK1/2 mitogen-activated protein kinases. International Immunopharmacology, 7(2), 230-240. https://doi.org/10.1016/j.intimp.2006.10.005
Aging enhances a mechanically-induced reduction in tendon strength by an active process involving matrix metalloproteinase activity
Journal Article
Dudhia, J., Scott, C. M., Draper, E. R. C., Heinegard, D., Pitsillides, A. A., & Smith, R. K. W. Aging enhances a mechanically-induced reduction in tendon strength by an active process involving matrix metalloproteinase activity. Aging Cell, 6(4), 547-556. https://doi.org/10.1111/j.1474-9726.2007.00307.x
THE INFLUENCE OF AGEING IN TENDON HOMEOSTASIS AND THE RISK OF TENDON INJURY
Journal Article
Smith, R. K. W., Dudhia, J., Scott, C. M., Draper, E., May, S. A., & Pitsillides, A. A. THE INFLUENCE OF AGEING IN TENDON HOMEOSTASIS AND THE RISK OF TENDON INJURY. International Journal of Experimental Pathology, 89(3), A25-A25
Identifying the cellular basis for reimplantation failure in repair of the rotator cuff
Journal Article
Simon, D. W. N., Clarkin, C. E., Das-Gupta, V., Rawlinson, S. C. F., Emery, R. J., & Pitsillides, A. A. Identifying the cellular basis for reimplantation failure in repair of the rotator cuff. https://doi.org/10.1302/0301-620x.90b5.20013We examined cultured osteoblasts derived from paired samples from the greater tuberosity and acromion from eight patients with large chronic tears of the rotator cuff. We found that osteoblasts from the tuberosity had no apparent response to mechanic... Read More about Identifying the cellular basis for reimplantation failure in repair of the rotator cuff.
Ammonia impairs neutrophil phagocytic function in liver disease
Journal Article
Shawcross, D. L., Wright, G. A. K., Stadlbauer, V., Hodges, S. J., Davies, N. A., Wheeler-Jones, C. P. D., …Jalan, R. Ammonia impairs neutrophil phagocytic function in liver disease. Hepatology, 48(4), 1202-12. https://doi.org/10.1002/hep.22474
Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts
Journal Article
Chen, Y. L., Leask, A., Abraham, D. J., Pala, D., Xu, S. W., Khan, K., …Eastwood, M. Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts. Arthritis and Rheumatism, 58(2), 577-585. https://doi.org/10.1002/art.23146Objective. To investigate the contribution of heparan sulfate proteoglycan and Ras/MEK/ERK to the overexpression of profibrotic proteins and the enhanced contractile ability of dermal fibroblasts from patients with systemic sclerosis (SSc; scleroderm... Read More about Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts.
Evaluation of VEGF-Mediated signaling in primary human cells reveals a paracrine action for VEGF in osteoblast-mediated crosstalk to endothelial cells
Journal Article
Clarkin, C. E., Emery, R. J., Pitsillides, A. A., & Wheeler-Jones, C. P. D. Evaluation of VEGF-Mediated signaling in primary human cells reveals a paracrine action for VEGF in osteoblast-mediated crosstalk to endothelial cells. Journal of Cellular Physiology, 214(2), 537-544. https://doi.org/10.1002/jcp.21234Communication between endothelial and bone cells is crucial for controlling vascular supply during bone growth, remodeling, and repair but the molecular mechanisms coordinating this intercellular crosstalk remain ill-defined. We have used primary hum... Read More about Evaluation of VEGF-Mediated signaling in primary human cells reveals a paracrine action for VEGF in osteoblast-mediated crosstalk to endothelial cells.
Heterotypic contact reveals a COX-2-mediated suppression of osteoblast differentiation by endothelial cells: A negative modulatory role for prostanoids in VEGF-mediated cell: cell communication?
Journal Article
Clarkin, C. E., Garonna, E., Pitsillides, A. A., & Wheeler-Jones, C. P. D. Heterotypic contact reveals a COX-2-mediated suppression of osteoblast differentiation by endothelial cells: A negative modulatory role for prostanoids in VEGF-mediated cell: cell communication?. Experimental Cell Research, 314(17), 3152-3161. https://doi.org/10.1016/j.yexcr.2008.07.027in bone, angiogenesis most be initiated appropriately, but limited once remodelling or repair is complete. Our recent findings have Supported a role for prostaglandins (PG), known modulators of osteoblast (OB) and endothelial cell (EC) behaviour, in... Read More about Heterotypic contact reveals a COX-2-mediated suppression of osteoblast differentiation by endothelial cells: A negative modulatory role for prostanoids in VEGF-mediated cell: cell communication?.