Regulation of UDP-Glucose Dehydrogenase Is Sufficient to Modulate Hyaluronan Production and Release, Control Sulfated GAG Synthesis, and Promote Chondrogenesis

Clarkin, C E; Allen, S; Kuiper, N J; Wheeler, B T; Wheeler-Jones, C P D; Pitsillides, A A

doi:10.1002/jcp.22393

OSTEOARTHRITIS AND THE IMMUNE PHENOTYPE OF THE STR/ORT MOUSE - WHERE DO THEY MEET?
Journal Article
Wentworth, D. N., Staines, K. A., Poulet, B., Constantinou, E., Palmer, D., & Pitsillides, A. A. OSTEOARTHRITIS AND THE IMMUNE PHENOTYPE OF THE STR/ORT MOUSE - WHERE DO THEY MEET?. International Journal of Experimental Pathology, 95(3), A36-A37

Follistatin-like 3 (FSTL3) mediated silencing of transforming growth factor ß (TGFß) signaling is essential for testicular aging and regulating testis size
Journal Article
Oldknow, K. J., Seebacher, J., Goswami, T., Villen, J., Pitsillides, A. A., O'Shaughnessy, P. J., …Mukherjee, A. Follistatin-like 3 (FSTL3) mediated silencing of transforming growth factor ß (TGFß) signaling is essential for testicular aging and regulating testis size. Endocrinology, 154(3), 1310-20. https://doi.org/10.1210/en.2012-1886

OSTEOARTHRITIS SEVERITY IN MALE OFFSPRING IS LINKED TO MATERNAL AGE AND PARITY IN STR/ORT MICE
Journal Article
Poulet, B., Hesketh, F. M., Chang, Y. M., & Pitsillides, A. A. OSTEOARTHRITIS SEVERITY IN MALE OFFSPRING IS LINKED TO MATERNAL AGE AND PARITY IN STR/ORT MICE. International Journal of Experimental Pathology, 94(5), A14-A14

Spontaneous osteoarthritis in Str/ort mice is unlikely due to greater vulnerability to mechanical trauma
Journal Article
Poulet, B., Westerhof, T. A. T., Hamilton, R. W., Shefelbine, S. J., & Pitsillides, A. A. Spontaneous osteoarthritis in Str/ort mice is unlikely due to greater vulnerability to mechanical trauma. Osteoarthritis and Cartilage, 21(5), 756-763. https://doi.org/10.1016/j.joca.2013.02.652

Susceptibility to spontaneous OA is not necessarily linked to a vulnerability of articular cartilage to mechanical trauma
Journal Article
Poulet, B., Westerhof, T., Shefelbine, S., & Pitsillides, A. A. Susceptibility to spontaneous OA is not necessarily linked to a vulnerability of articular cartilage to mechanical trauma. Osteoarthritis and Cartilage,

THICKENING OF SUBCHONDRAL BONE IS REGIONALISED BY LOADING OF DAMAGED ARTICULAR CARTILAGE AND CONTRA-LATERAL CHANGES ARE LINKED TO GAIT MODIFICATION
Journal Article
Poulet, B., de Souza, R., Kent, A. V., Saxon, L. K., Barker, O., Wilson, A. M., …Pitsillides, A. A. THICKENING OF SUBCHONDRAL BONE IS REGIONALISED BY LOADING OF DAMAGED ARTICULAR CARTILAGE AND CONTRA-LATERAL CHANGES ARE LINKED TO GAIT MODIFICATION. Osteoarthritis and Cartilage, 21, S68-S68

Cartilage to bone transitions in health and disease
Journal Article
Staines, K. A., Pollard, A. S., McGonnell, I. M., Farquharson, C., & Pitsillides, A. A. Cartilage to bone transitions in health and disease. Journal of Endocrinology, 219(1), R1-R12. https://doi.org/10.1530/joe-13-0276

THE SCLEROSTIN AND MEPE AXIS IN THE DEVELOPMENT OF OSTEOARTHRTTIS
Journal Article
Staines, K. A., Poulet, B., Farquharson, C., & Pitsillides, A. A. THE SCLEROSTIN AND MEPE AXIS IN THE DEVELOPMENT OF OSTEOARTHRTTIS. Osteoarthritis and Cartilage, 21, S55-S55

STABILISING CARTILAGE TO INNATELY PROTECT AGAINST OSTEOARTHRITIS: LESSONS FROM LONG BONE DEVELOPMENT
Journal Article
Staines, K. A., Poulet, B., Farquharson, C., & Pitsillides, A. A. STABILISING CARTILAGE TO INNATELY PROTECT AGAINST OSTEOARTHRITIS: LESSONS FROM LONG BONE DEVELOPMENT. International Journal of Experimental Pathology, 94(5), A3-A4

NEW BONE FOR OLD CARTILAGE; GROWTH PATTERNS OF THE BIZARRE 'SIXTH TOES' OF ELEPHANTS
Journal Article
Boyde, A., Pitsillides, A. A., & Hutchinson, J. R. NEW BONE FOR OLD CARTILAGE; GROWTH PATTERNS OF THE BIZARRE 'SIXTH TOES' OF ELEPHANTS. Osteoporosis International, 23, S557-S557

Expression of endothelial nitric oxide synthase protein is not necessary for mechanical strain-induced nitric oxide production by cultured osteoblasts
Journal Article
Das-Gupta, V., Williamson, R. A., & Pitsillides, A. A. Expression of endothelial nitric oxide synthase protein is not necessary for mechanical strain-induced nitric oxide production by cultured osteoblasts. Osteoporosis International, 23(11), 2635-2647. https://doi.org/10.1007/s00198-012-1957-2

DOES THE VASODILATORY ACTION OF PTH HELP ACCOUNT FOR ITS OSTEOGENIC EFFECTS?
Journal Article
Marenzana, M., Chenu, C., Pitsillides, A. A., & Arnett, T. R. DOES THE VASODILATORY ACTION OF PTH HELP ACCOUNT FOR ITS OSTEOGENIC EFFECTS?. BONE, 50, S160-S160. https://doi.org/10.1016/j.bone.2012.02.502

Cervical expression of hyaluronan synthases varies with the stage of the estrous cycle in the ewe
Journal Article
Perry, K. L., Haresign, W., Wathes, D. C., Pitsillides, A. A., & Khalid, M. Cervical expression of hyaluronan synthases varies with the stage of the estrous cycle in the ewe. Theriogenology, 77(6), 1100-1110. https://doi.org/10.1016/j.theriogenology.2011.10.012

Using Cell and Organ Culture Models to Analyze Responses of Bone Cells to Mechanical Stimulation
Book Chapter
Pitsillides, A. A., & Rawlinson, S. C. F. Using Cell and Organ Culture Models to Analyze Responses of Bone Cells to Mechanical Stimulation. . https://doi.org/10.1007/978-1-61779-415-5_37

Time-series transcriptional profiling yields new perspectives on susceptibility to murine osteoarthritis
Journal Article
Poulet, B., Ulici, V., Stone, T. C., Pead, M. J., Gburcik, V., Constantinou, E., …Pitsillides, A. A. Time-series transcriptional profiling yields new perspectives on susceptibility to murine osteoarthritis. Arthritis and Rheumatism, 64(10), 3256-3266. https://doi.org/10.1002/art.34572

GENE ARRAY PROFILING OF ARTICULAR CHONDROCYTES IN MICE WITH DIFFERENT SUSCEPTIBILITY TO NATURAL DISEASE REVEALS SPECIFIC GENE SIGNATURES LINKED TO HEALTHY AGEING AND SPONTANEOUS OA
Journal Article
Poulet, B., Veronica, U., Stone, T. C., Pead, M., Gburcik, V., Beier, F., …Pitsillides, A. A. GENE ARRAY PROFILING OF ARTICULAR CHONDROCYTES IN MICE WITH DIFFERENT SUSCEPTIBILITY TO NATURAL DISEASE REVEALS SPECIFIC GENE SIGNATURES LINKED TO HEALTHY AGEING AND SPONTANEOUS OA. Osteoarthritis and Cartilage, 20, S59-S60

Extracellular Matrix Mineralization Promotes E11/gp38 Glycoprotein Expression and Drives Osteocytic Differentiation
Journal Article
Prideaux, M., Loveridge, N., Pitsillides, A. A., & Farquharson, C. Extracellular Matrix Mineralization Promotes E11/gp38 Glycoprotein Expression and Drives Osteocytic Differentiation. PLoS ONE, 7(5), e36786. https://doi.org/10.1371/journal.pone.0036786

LIKE A HOLE IN THE HEAD; DEVELOPMENT OF CRANIAL FORAMINA IN THE CHICK EMBRYO
Journal Article
Akbareian, S. E., Pitsillides, A. A., Fowkes, R. C., & McGonnell, I. M. LIKE A HOLE IN THE HEAD; DEVELOPMENT OF CRANIAL FORAMINA IN THE CHICK EMBRYO. Journal of Anatomy, 218(3), 351-351

Reduced chondrogenic matrix accumulation by 4-methylumbelliferone reveals the potential for selective targeting of UDP-glucose dehydrogenase
Journal Article
Clarkin, C. E., Allen, S. P., Wheeler-Jones, C. P. D., Bastow, E. R., & Pitsillides, A. A. Reduced chondrogenic matrix accumulation by 4-methylumbelliferone reveals the potential for selective targeting of UDP-glucose dehydrogenase. Matrix Biology, 30(3), 163-168. https://doi.org/10.1016/j.matbio.2011.01.002

Regulation of UDP-Glucose Dehydrogenase Is Sufficient to Modulate Hyaluronan Production and Release, Control Sulfated GAG Synthesis, and Promote Chondrogenesis
Journal Article
Clarkin, C. E., Allen, S., Kuiper, N. J., Wheeler, B. T., Wheeler-Jones, C. P. D., & Pitsillides, A. A. Regulation of UDP-Glucose Dehydrogenase Is Sufficient to Modulate Hyaluronan Production and Release, Control Sulfated GAG Synthesis, and Promote Chondrogenesis. Journal of Cellular Physiology, 226(3), 749-761. https://doi.org/10.1002/jcp.22393

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