Role of glycosylphosphatidylinositols in the activation of phospholipase A(2) and the neurotoxicity of prions

Bate, C; Williams, A

doi:10.1099/vir.0.80366-0

Monoacylated Cellular Prion Protein Modifies Cell Membranes, Inhibits Cell Signaling, and Reduces Prion Formation
Journal Article
Bate, C., & Williams, A. Monoacylated Cellular Prion Protein Modifies Cell Membranes, Inhibits Cell Signaling, and Reduces Prion Formation. Journal of Biological Chemistry, 286(11), 8752-8758. https://doi.org/10.1074/jbc.M110.186833

The cellular prion protein with a monoacylated glycosylphosphatidylinositol anchor modifies cell membranes, inhibits cell signaling and reduces prion formation
Journal Article
Bate, C., & Williams, A. The cellular prion protein with a monoacylated glycosylphosphatidylinositol anchor modifies cell membranes, inhibits cell signaling and reduces prion formation. Prion, 5(2), 65-68. https://doi.org/10.4161/pri.5.2.16095

Alpha-synuclein induced synapse damage is enhanced by amyloid-beta
Journal Article
Bate, C., Gentleman, S., & Williams, A. Alpha-synuclein induced synapse damage is enhanced by amyloid-beta. Molecular Neurodegeneration, 5(55), https://doi.org/10.1186/1750-1326-5-55

Polyunsaturated Fatty Acids Protect Against Prion-Mediated Synapse Damage In Vitro
Journal Article
Bate, C., Tayebi, M., Salmona, M., Diomede, L., & Williams, A. Polyunsaturated Fatty Acids Protect Against Prion-Mediated Synapse Damage In Vitro. Neurotoxicity Research, 17(3), 203-214. https://doi.org/10.1007/s12640-009-9093-2

Glycosylphosphatidylinositol Anchor Analogues Sequester Cholesterol and Reduce Prion Formation
Journal Article
Bate, C., Tayebi, M., & Williams, A. Glycosylphosphatidylinositol Anchor Analogues Sequester Cholesterol and Reduce Prion Formation. Journal of Biological Chemistry, 285(29), 22017-22026. https://doi.org/10.1074/jbc.M110.108548

Phospholipase A(2) inhibitors protect against prion and A beta mediated synapse degeneration
Journal Article
Bate, C., Tayebi, M., & Williams, A. Phospholipase A(2) inhibitors protect against prion and A beta mediated synapse degeneration. Molecular Neurodegeneration, 5(13), https://doi.org/10.1186/1750-1326-5-13

A glycosylphosphatidylinositol analogue reduced prion-derived peptide mediated activation of cytoplasmic phospholipase A(2), synapse degeneration and neuronal death
Journal Article
Bate, C., Tayebi, M., & Williams, A. A glycosylphosphatidylinositol analogue reduced prion-derived peptide mediated activation of cytoplasmic phospholipase A(2), synapse degeneration and neuronal death. Neuropharmacology, 59(1-2), 93-99. https://doi.org/10.1016/j.neuropharm.2010.04.002

The glycosylphosphatidylinositol anchor is a major determinant of prion binding and replication
Journal Article
Bate, C., Tayebi, M., & Williams, A. The glycosylphosphatidylinositol anchor is a major determinant of prion binding and replication. Biochemical Journal, 428, 95-101. https://doi.org/10.1042/bj20091469

Amyloid-beta(1-40) Inhibits Amyloid-beta(1-42) Induced Activation of Cytoplasmic Phospholipase A(2) and Synapse Degeneration
Journal Article
Bate, C., & Williams, A. Amyloid-beta(1-40) Inhibits Amyloid-beta(1-42) Induced Activation of Cytoplasmic Phospholipase A(2) and Synapse Degeneration. Journal of Alzheimer's Disease, 21(3), 985-993. https://doi.org/10.3233/jad-2010-100528

A Camelid Anti-PrP Antibody Abrogates PrPSc Replication in Prion-Permissive Neuroblastoma Cell Lines
Journal Article
Jones, D. R., Taylor, W. A., Bate, C., David, M., & Tayebi, M. A Camelid Anti-PrP Antibody Abrogates PrPSc Replication in Prion-Permissive Neuroblastoma Cell Lines. PLoS ONE, 5(3), https://doi.org/10.1371/journal.pone.0009804

Epitope-specific anti-prion antibodies upregulate apolipoprotein E and disrupt membrane cholesterol homeostasis
Journal Article
Tayebi, M., David, M., Bate, C., Jones, D. R., Taylor, W., Morton, R., …Hawke, S. Epitope-specific anti-prion antibodies upregulate apolipoprotein E and disrupt membrane cholesterol homeostasis. Journal of General Virology, 91(Pt12), 3105-3115. https://doi.org/10.1099/vir.0.023838-0

PrP-specific camel antibodies with the ability to immunodetect intracellular prion protein
Journal Article
Tayebi, M., Taylor, W. A., Jones, D. R., Bate, C., & David, M. PrP-specific camel antibodies with the ability to immunodetect intracellular prion protein. Journal of General Virology, 91, 2121-2131. https://doi.org/10.1099/vir.0.018754-0

Glimepiride Reduces the Expression of PrPC, Prevents PrPSc Formation and Protects against Prion Mediated Neurotoxicity
Journal Article
Bate, C., Tayebi, M., Diomede, L., Salmona, M., & Williams, A. Glimepiride Reduces the Expression of PrPC, Prevents PrPSc Formation and Protects against Prion Mediated Neurotoxicity. PLoS ONE, 4(12), e8221. https://doi.org/10.1371/journal.pone.0008221

LIPID RAFTS, CELL SIGNALLING, PRION FORMATION AND NEURODEGENERATION IN PRION DISEASES
Journal Article
Williams, A., & Bate, C. LIPID RAFTS, CELL SIGNALLING, PRION FORMATION AND NEURODEGENERATION IN PRION DISEASES. Journal of Neurochemistry, 108, 44-44

Do prion-induced changes in cholesterol trigger neurodegeneration?
Journal Article
Bate, C., & Williams, A. Do prion-induced changes in cholesterol trigger neurodegeneration?. Future Neurology, 3(4), 367-370. https://doi.org/10.2217/14796708.3.4.367

Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A(2) activation
Journal Article
Bate, C., Tayebi, M., & Williams, A. Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A(2) activation. BMC Biology, 6, https://doi.org/10.1186/1741-7007-6-8

Background: The transmissible spongiform encephalopathies (TSEs), otherwise known as the prion diseases, occur following the conversion of the normal cellular prion protein ( PrPC) to an alternatively folded isoform ( PrPSc). The accumulation of PrPS... Read More about Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A(2) activation.

Ginkgolides protect against amyloid-beta(1-42)-mediated synapse damage in vitro
Journal Article
Bate, C., Tayebi, M., & Williams, A. Ginkgolides protect against amyloid-beta(1-42)-mediated synapse damage in vitro. Molecular Neurodegeneration, 3(1), https://doi.org/10.1186/1750-1326-3-1

Cholesterol esterification reduces the neurotoxicity of prions
Journal Article
Bate, C., Tayebi, M., & Williams, A. Cholesterol esterification reduces the neurotoxicity of prions. Neuropharmacology, 54(8), 1247-1253. https://doi.org/10.1016/j.neuropharm.2008.04.002

The transmissible spongiform encephalopathies develop following the conversion of a host-encoded protein (PrPC) into abnormally folded, disease-related isoforms (PrPSc). Here we report that three acylcoenzyme A:cholesterol acyltransferase (ACAT) inhi... Read More about Cholesterol esterification reduces the neurotoxicity of prions.

Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells
Journal Article
Bate, C., Tayebi, M., Diomede, L., Salmona, M., & Williams, A. Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells. BMC Biology, 6, https://doi.org/10.1186/1741-7007-6-39

Background: The transmissible spongiform encephalopathies, otherwise known as prion diseases, occur following the conversion of the cellular prion protein (PrPC) to an alternatively folded, disease-associated isoform (PrPSc). Recent studies suggest t... Read More about Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells.

Role of glycosylphosphatidylinositols in the activation of phospholipase A(2) and the neurotoxicity of prions
Journal Article
Bate, C., & Williams, A. Role of glycosylphosphatidylinositols in the activation of phospholipase A(2) and the neurotoxicity of prions. Journal of General Virology, 85(85), 3797-3804. https://doi.org/10.1099/vir.0.80366-0

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