All Outputs (146)

Theileria Apicoplast as a Target for Chemotherapy
Journal Article
Lizundia, R., Werling, D., Langsley, G., & Ralph, S. A. Theileria Apicoplast as a Target for Chemotherapy. Antimicrobial Agents and Chemotherapy, 53(3), 1213-1217. https://doi.org/10.1128/aac.00126-08

Theileria parasites cause severe bovine disease and death in a large part of the world. These apicomplexan parasites possess a relic plastid (apicoplast), whose metabolic pathways include several promising drug targets. Putative inhibitors of these t... Read More about Theileria Apicoplast as a Target for Chemotherapy.

Variation matters: TLR structure and species-specific pathogen recognition
Journal Article
Werling, D., Jann, O. C., Offord, V., Glass, E. J., & Coffey, T. J. Variation matters: TLR structure and species-specific pathogen recognition. Trends in Immunology, 30(3), 124-130. https://doi.org/10.1016/j.it.2008.12.001

Toll-like receptors (TLRs) are a family of pattern recognition receptors that are an important link between innate and adaptive immunity. Many vaccines incorporate ligands for TLRs as an adjuvant and are developed in rodent models, with the resulting... Read More about Variation matters: TLR structure and species-specific pathogen recognition.

Pattern recognition receptors in companion and farm animals - The key to unlocking the door to animal disease?
Journal Article
Werling, D., & Coffey, T. J. Pattern recognition receptors in companion and farm animals - The key to unlocking the door to animal disease?. https://doi.org/10.1016/j.tvjl.2006.10.010

CHARACTERIZATION OF THE BACTERIAL MICROFLORA AND INNATE IMMUNITY RESPONSE IN GERMAN SHEPHERD DOGS WITH ANTIBIOTIC-RESPONSIVE DIARRHEA
Journal Article
Allenspach, K., Suchodolski, J. S., McNeill, F. M., House, A., Hendricks, A., Xenoulis, P. G., …Werling, D. CHARACTERIZATION OF THE BACTERIAL MICROFLORA AND INNATE IMMUNITY RESPONSE IN GERMAN SHEPHERD DOGS WITH ANTIBIOTIC-RESPONSIVE DIARRHEA. Journal of Veterinary Internal Medicine, 22(3), 748-748

Cytokine responses of bovine dendritic cells and T cells following exposure to live or inactivated bovine respiratory syncytial virus
Journal Article
Werling, D., Collins, R. A., Taylor, G., & Howard, C. J. Cytokine responses of bovine dendritic cells and T cells following exposure to live or inactivated bovine respiratory syncytial virus. Journal of Leukocyte Biology, 72(2), 297-304

Single Nucleotide Polymorphisms in the Bovine TLR2 Extracellular Domain Contribute to Breed 1 and Species-Specific Innate Immune Functionality 2 3
Journal Article
Bartens, M., Gibson, A. J., Etherington, G. J., Di Palma, F., Holder, A., Werling, D., & Willcocks, S. Single Nucleotide Polymorphisms in the Bovine TLR2 Extracellular Domain Contribute to Breed 1 and Species-Specific Innate Immune Functionality 2 3. Frontiers in Immunology,

17 18 Recent evidence suggests that several cattle breeds may be more resistant to infection with the zoonotic 19 pathogen Mycobacterium bovis. Our data presented here suggests that the response to mycobacterial 20 antigens varies in macrophages gene... Read More about Single Nucleotide Polymorphisms in the Bovine TLR2 Extracellular Domain Contribute to Breed 1 and Species-Specific Innate Immune Functionality 2 3.