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A tumour necrosis factor alpha autocrine loop contributes to proliferation and nuclear factor-kappa B activation of Theileria parva-transformed B cells
Journal Article
Guergnon, J., Chaussepied, M., Sopp, P., Lizundia, R., Moreau, M. F., Blumen, B., Werling, D., Howard, C. J., & Langsley, G. A tumour necrosis factor alpha autocrine loop contributes to proliferation and nuclear factor-kappa B activation of Theileria parva-transformed B cells. Cellular Microbiology, 5(10), 709-716. https://doi.org/10.1046/j.1462-5822.2003.00314.x

Identification and functional characterization of a bovine orthologue to DC-SIGN
Journal Article
Yamakawa, Y., Pennelegion, C., Willcocks, S., Stalker, A., MacHugh, N., Burt, D., Coffey, T. J., & Werling, D. Identification and functional characterization of a bovine orthologue to DC-SIGN. Journal of Leukocyte Biology, 83(6), 1396-1403. https://doi.org/10.1189/jlb.0807523

Dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) C-type lectin is almost exclusively expressed at the cell surface of DC. In addition to its normal function facilitating contact of DC with T cells, DC-SIGN has been shown to bind a variet... Read More about Identification and functional characterization of a bovine orthologue to DC-SIGN.

Molecular evolution of bovine Toll-like receptor 2 suggests substitutions of functional relevance
Journal Article
Jann, O. C., Werling, D., Chang, J. S., Haig, D., & Glass, E. J. Molecular evolution of bovine Toll-like receptor 2 suggests substitutions of functional relevance. BMC Evolutionary Biology, 8(288), https://doi.org/10.1186/1471-2148-8-288

Background: There is accumulating evidence that polymorphism in Toll-like receptor (TLR) genes might be associated with disease resistance or susceptibility traits in livestock. Polymorphic sites affecting TLR function should exhibit signatures of po... Read More about Molecular evolution of bovine Toll-like receptor 2 suggests substitutions of functional relevance.

Host species-specific usage of the TLR4-LPS receptor complex
Journal Article
Lizundia, R., Sauter, K. S., Taylor, G., & Werling, D. Host species-specific usage of the TLR4-LPS receptor complex. Innate Immunity, 14(4), 223-231. https://doi.org/10.1177/1753425908095957

Recognition of LIPS depends on the interaction of at least three molecules forming the LPS-receptor complex. The Most important ones, CD14. MD2 and Toll-like receptor (TLR) 4 share a high degree of homology between species. In the present study, we i... Read More about Host species-specific usage of the TLR4-LPS receptor complex.

Poly I:C stimulation in-vitro as a marker for an antiviral response in different cell types generated from Buffalo (Bubalus bubalis)
Journal Article
Vats, A., Gautam, D., Maharana, J., Chera, J. S., Kumar, S., Werling, D., & De, S. (in press). Poly I:C stimulation in-vitro as a marker for an antiviral response in different cell types generated from Buffalo (Bubalus bubalis). Molecular Immunology, 121, 136-143. https://doi.org/10.1016/j.molimm.2020.03.004

The innate immune system is activated upon virus invasion of a host cell by recognizing viral component, such as dsRNA through specific receptors, resulting in the production of type- I IFNs, which confer an antiviral state within the invaded as well... Read More about Poly I:C stimulation in-vitro as a marker for an antiviral response in different cell types generated from Buffalo (Bubalus bubalis).

Poly I:C stimulation in-vitro as a marker for an antiviral response in different cell types generated from Buffalo (Bubalus bubalis)
Journal Article
Vats, A., Gautam, D., Maharana, J., Singh Chera, J., Kumar, S., Rout, P. K., Werling, D., & De, S. Poly I:C stimulation in-vitro as a marker for an antiviral response in different cell types generated from Buffalo (Bubalus bubalis). Molecular Immunology, 121, 136-143

The innate immune system is activated upon virus invasion of a host cell by recognizing viral component, such as dsRNA through specific receptors, resulting in the production of type- I IFNs, which confer an antiviral state within the invaded as well... Read More about Poly I:C stimulation in-vitro as a marker for an antiviral response in different cell types generated from Buffalo (Bubalus bubalis).

Prediction of metabolic clusters in early-lactation dairy cows using models based on milk biomarkers
Journal Article
De Koster, J., Salavati, M., Grelet, C., Crowe, M. A., Matthews, E., O'Flaherty, R., Opsomer, G., Foldager, L., Hostens, M., McLoughlin, N., Fahey, A., Santoro, A., Byrne, C., Rudd, P., Hallinan, S., Wathes, D. C., Cheng, Z. R., Fouladi-Nashta, A. A., Pollott, G., Werling, D., …Vrea, S. P. Prediction of metabolic clusters in early-lactation dairy cows using models based on milk biomarkers. Journal of Dairy Science, 102(3), 2631-2644. https://doi.org/10.3168/jds.2018-15533

Cardiosphere-derived cells suppress allogeneic lymphocytes by production of PGE2 acting via the EP4 receptor
Journal Article
Dutton, L. C., Dudhia, J., Catchpole, B., Hodhkiss-Geere, H., Werling, D., & Connolly, D. J. (in press). Cardiosphere-derived cells suppress allogeneic lymphocytes by production of PGE2 acting via the EP4 receptor. https://doi.org/10.1038/s41598-018-31569-1

derived cells (CDCs) are a cardiac progenitor cell population, which have been shown to possess cardiac regenerative properties and can improve heart function in a variety of cardiac diseases. Studies in large animal models have predominantly focusse... Read More about Cardiosphere-derived cells suppress allogeneic lymphocytes by production of PGE2 acting via the EP4 receptor.