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All Outputs (75)

The role of chick Ebf genes in the mediolateral patterning of the somites (2019)
Journal Article
EL-Magd, M. A., Elsayed, S. A., El-Shetry, E. S., Abdelfattah-Hassan, A., Saleh, A. A., Allen, S., …Patel, K. (2019). The role of chick Ebf genes in the mediolateral patterning of the somites. https://doi.org/10.1002/dvg.23339

This study was conducted to check whether the three chick Early B‐cell Factor (Ebf) genes, particularly cEbf1, would be targets for Shh and Bmp signals during somites mediolateral (ML) patterning. Tissue manipulations and gain and loss of function ex... Read More about The role of chick Ebf genes in the mediolateral patterning of the somites.

Pituitary pathology and gene expression in acromegalic cats (2019)
Journal Article
Scudder, C. J., Mirczuk, S. M., Richardson, K. M., Crossley, V. J., Regan, J. T. C., Gostelow, R., …Niessen, S. J. M. (2019). Pituitary pathology and gene expression in acromegalic cats. Journal of the Endocrine Society, 3(1), 181-200. https://doi.org/10.1210/js.2018-00226

The prevalence of growth hormone secreting pituitary tumours in domestic cats (Felis catus) is ten times greater than in humans. The predominant inhibitory receptors of growth hormone-secreting pituitary tumours are somatostatin receptors (SSTRs) and... Read More about Pituitary pathology and gene expression in acromegalic cats.

Like a hole in the head: Development, evolutionary implications and diseases of the cranial foramina (2018)
Journal Article
McGonnell, I. M., & Akbareian, S. E. (2018). Like a hole in the head: Development, evolutionary implications and diseases of the cranial foramina. https://doi.org/10.1016/j.semcdb.2018.08.011

Cranial foramina are holes in the skull through which nerves and blood vessels pass to reach both deep and superficial tissues. They are often overlooked in the literature; however they are complex structures that form within the developing cranial b... Read More about Like a hole in the head: Development, evolutionary implications and diseases of the cranial foramina.

Distinct cerebellar foliation anomalies in a Chd7 haploinsufficient mouse model of CHARGE syndrome (2017)
Journal Article
Whittaker, D. E., Kasah, S., Donovan, A. P. A., Ellegood, J., Riegman, K. L. H., Volk, H. A., …Basson, A. (2017). Distinct cerebellar foliation anomalies in a Chd7 haploinsufficient mouse model of CHARGE syndrome. American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 175(4), 465-477. https://doi.org/10.1002/ajmg.c.31595

Mutations in the gene encoding the ATP dependent chromatin‐remodeling factor, CHD7 are the major cause of CHARGE (Coloboma, Heart defects, Atresia of the choanae, Retarded growth and development, Genital‐urinary anomalies, and Ear defects) syndrome.... Read More about Distinct cerebellar foliation anomalies in a Chd7 haploinsufficient mouse model of CHARGE syndrome.

Natriuretic peptide activation of extracellular regulated kinase 1/2 (ERK1/2) pathway by particulate guanylyl cyclases in GH3 somatolactotropes (2017)
Journal Article
Jonas, K. C., Melrose, T., Thompson, I. R., Baxter, G. F., Lipscomb, V. J., Niessen, S. J. M., …Fowkes, R. C. (2017). Natriuretic peptide activation of extracellular regulated kinase 1/2 (ERK1/2) pathway by particulate guanylyl cyclases in GH3 somatolactotropes. Cell and Tissue Research, 369(3), 567-578. https://doi.org/10.1007/s00441-017-2624-x

The natriuretic peptides, Atrial-, B-type and C-type natriuretric peptides (ANP, BNP, CNP), are regulators of many endocrine tissues and exert their effects predominantly through the activation of their specific guanylyl cyclase receptors (GC-A and G... Read More about Natriuretic peptide activation of extracellular regulated kinase 1/2 (ERK1/2) pathway by particulate guanylyl cyclases in GH3 somatolactotropes.

The chromatin remodeling factor CHD7 controls cerebellar development by regulating reelin expression (2017)
Journal Article
Whittaker, D. E., Riegman, K. L. H., Kasah, S., Mohan, C., Yu, T., Sala, B. P., …Basson, M. A. (2017). The chromatin remodeling factor CHD7 controls cerebellar development by regulating reelin expression. Journal of Clinical Investigation, 127(3), 874-887. https://doi.org/10.1172/JCI83408

The mechanisms underlying the neurodevelopmental deficits associated with CHARGE syndrome, which include cerebellar hypoplasia, developmental delay, coordination problems, and autistic features, have not been identified. CHARGE syndrome has been asso... Read More about The chromatin remodeling factor CHD7 controls cerebellar development by regulating reelin expression.

The role of embryo movement in the development of the furcula (2017)
Journal Article
Pollard, A. S., Boyd, S., McGonnell, I. M., & Pitsillides, A. A. (2017). The role of embryo movement in the development of the furcula. Journal of Anatomy, 230(3), 435-443. https://doi.org/10.1111/joa.12571

The pectoral girdle is a complex structure which varies in its morphology between species. A major component in birds is the furcula, which can be considered equivalent to a fusion of the paired clavicles found in many mammals, and the single intercl... Read More about The role of embryo movement in the development of the furcula.

Limb proportions show developmental plasticity in response to embryo movement (2017)
Journal Article
Pollard, A. S., Charlton, B. G., Hutchinson, J. R., Gustafsson, T., McGonnell, I. M., Timmons, J. A., & Pitsillides, A. A. (2017). Limb proportions show developmental plasticity in response to embryo movement. https://doi.org/10.1038/srep41926

Animals have evolved limb proportions adapted to different environments, but it is not yet clear to what extent these proportions are directly influenced by the environment during prenatal development. The developing skeleton experiences mechanical l... Read More about Limb proportions show developmental plasticity in response to embryo movement.

Quantitative Expression and Co-Localization of Wnt Signalling Related Proteins in Feline Squamous Cell Carcinoma (2016)
Journal Article
Giuliano, A., Swift, R., Arthurs, C., Marote, G., Abramo, F., McKay, J., …Ahmed, A. (2016). Quantitative Expression and Co-Localization of Wnt Signalling Related Proteins in Feline Squamous Cell Carcinoma. PLoS ONE, 11(8), e0161103. https://doi.org/10.1371/journal.pone.0161103

Feline oral squamous cell carcinoma (FOSCC) is an aggressive neoplasm in cats. Little is known about the possible molecular mechanisms that may be involved in the initiation, maintenance and progression of FOSCC. Wnt signalling is critical in develop... Read More about Quantitative Expression and Co-Localization of Wnt Signalling Related Proteins in Feline Squamous Cell Carcinoma.

Occipital foramina development involves localised regulation of mesenchyme proliferation and is independent of apoptosis (2015)
Journal Article
Akbareian, S. E., Pitsillides, A. A., Macharia, R. G., & McGonnell, I. M. (2015). Occipital foramina development involves localised regulation of mesenchyme proliferation and is independent of apoptosis. Journal of Anatomy, 226(6), 560-574. https://doi.org/10.1111/joa.12304

Cranial foramina are holes within the skull, formed during development, allowing entry and exit of blood vessels and nerves. Once formed they must remain open, due to the vital structures they contain, i.e. optic nerves, jugular vein, carotid artery,... Read More about Occipital foramina development involves localised regulation of mesenchyme proliferation and is independent of apoptosis.

Shh regulates chick Ebf1 gene expression in somite development (2015)
Journal Article
El-Magd, M. A., Allen, S. P., McGonnell, I. M., Mansour, A. A., Otto, A., & Patel, K. (2015). Shh regulates chick Ebf1 gene expression in somite development. Gene, 554(1), 87-95. https://doi.org/10.1016/j.gene.2014.10.028

The chick early B-cell factor 1 (cEbf1) is a member of EBF family of helix loop helix transcription factors. Recently, we have proved that cEbf1 expression in feather is regulated by Shh. It is therefore possible that the somitic expression of cEbf1... Read More about Shh regulates chick Ebf1 gene expression in somite development.

Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes (2014)
Journal Article
Thompson, I. R., Mirczuk, S. M., Smith, L., Lessey, A. J., Simbi, B., Sunters, A., …Fowkes, R. C. (2014). Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes. Cell and Tissue Research, 355(2), 425-36. https://doi.org/10.1007/s00441-013-1763-y

The guanylyl cyclases, GC-A and GC-B, are selective receptors for atrial and C-type natriuretic peptides (ANP and CNP, respectively). In the anterior pituitary, CNP and GC-B are major regulators of cGMP production in gonadotropes and yet mouse models... Read More about Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes.

Effect of transportation duration of 1-day-old chicks on postplacement production performances and pododermatitis of broilers up to slaughter age (2013)
Journal Article
Bergoug, H., Guinebretiere, M., Tong, Q., Roulston, N., Romanini, C. E. B., Exadaktylos, V., …Michel, V. (2013). Effect of transportation duration of 1-day-old chicks on postplacement production performances and pododermatitis of broilers up to slaughter age. Poultry Science, 92(12), 3300-3309. https://doi.org/10.3382/ps.2013-03118

This experiment studied the effect of transportation duration of 1-d-old chicks on dehydration, mortality, production performance, and pododermatitis during the growout period. Eggs from the same breeder flock (Ross PM3) were collected at 35, 45, and... Read More about Effect of transportation duration of 1-day-old chicks on postplacement production performances and pododermatitis of broilers up to slaughter age.