All Outputs (7)

Ondansetron in dogs with nausea associated with vestibular disease: A double-blinded, randomized placebo-controlled crossover study (2022)
Journal Article
Henze, L., Foth, S., Meller, S., Twele, F., Charalambous, M., Kenward, H., Elliott, J., Pelligand, L., & Volk, H. (2022). Ondansetron in dogs with nausea associated with vestibular disease: A double-blinded, randomized placebo-controlled crossover study. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16504

Background: Nausea and emesis can be, among other signs, common manifestations
of acute vestibular system dysfunction in dogs. Currently, antiemetic drugs, such as
maropitant and metoclopramide, are used commonly, but do not appear to control
naus... Read More about Ondansetron in dogs with nausea associated with vestibular disease: A double-blinded, randomized placebo-controlled crossover study.

Nitric oxide synthase inhibition reveals differences in the nitric oxide pathway in previously laminitic ponies. (2022)
Journal Article
Finding, E., Elliott, J., Harris, P., & Menzies-Gow, N. (2022). Nitric oxide synthase inhibition reveals differences in the nitric oxide pathway in previously laminitic ponies. Research in Veterinary Science, https://doi.org/10.1016/j.rvsc.2022.05.012

Previously laminitic (PL) ponies are reported to have higher blood pressure than non laminitic (NL) ponies. This relative hypertension may be related to endothelial cell dysfunction, similar to humans with metabolic syndrome. To investigate the relat... Read More about Nitric oxide synthase inhibition reveals differences in the nitric oxide pathway in previously laminitic ponies..

Ionized hypercalcemia in cats with azotemic chronic kidney disease (2012-2018) (2022)
Journal Article
van den Broek, D., Geddes, R., Lotter, N., Chang, Y., Elliott, J., & Jepson, R. (2022). Ionized hypercalcemia in cats with azotemic chronic kidney disease (2012-2018). Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16430

Background Hypercalcemia is associated with chronic kidney disease (CKD) in cats, but studies assessing the physiologically relevant ionized calcium fraction are lacking. Objectives To describe the prevalence and incidence rate of ionized hypercalcem... Read More about Ionized hypercalcemia in cats with azotemic chronic kidney disease (2012-2018).

New concepts in phosphorus homeostasis and its impact on renal health with particular reference to the cat (2022)
Journal Article
Elliott, J., & Geddes, R. F. (2022). New concepts in phosphorus homeostasis and its impact on renal health with particular reference to the cat. The Veterinary Journal, 283-284, Article 105842. https://doi.org/10.1016/j.tvjl.2022.105842

New discoveries relating to phosphorus homeostasis include the hormones fibroblast growth factor-23 and klotho produced by bone and kidney. These hormones, together with novel understanding of how calcium and phosphate ions are carried in colloidal f... Read More about New concepts in phosphorus homeostasis and its impact on renal health with particular reference to the cat.

Pharmacology, safety, efficacy and clinical uses of the COX‐2 inhibitor robenacoxib (2022)
Journal Article
Lees, P., Toutain, P., Elliott, J., Giraudel, J. M., Pelligand, L., & King, J. N. (2022). Pharmacology, safety, efficacy and clinical uses of the COX‐2 inhibitor robenacoxib. Journal of Veterinary Pharmacology and Therapeutics, 45(4), 325-351. https://doi.org/10.1111/jvp.13052

Robenacoxib is a veterinary-approved non-steroidal anti-inflammatory drug (NSAID) of the coxib group. It possesses anti-hyperalgesic, anti-inflammatory and anti-pyretic properties. Robenacoxib inhibits the cyclooxygenase (COX)-2 isoform of COX select... Read More about Pharmacology, safety, efficacy and clinical uses of the COX‐2 inhibitor robenacoxib.

First Genome-Wide Association Study Investigating Blood Pressure and Renal Traits in Domestic Cats (2022)
Journal Article
Jepson, R. E., Warren, H., Syme, H. M., Elliott, J., & Munroe, P. B. (2022). First Genome-Wide Association Study Investigating Blood Pressure and Renal Traits in Domestic Cats. Scientific Reports, https://doi.org/10.1038/s41598-022-05494-3

Hypertension (HTN) and chronic kidney disease (CKD) are common in ageing cats. In humans, blood pressure (BP) and renal function are complex heritable traits. We performed the first feline Genome-Wide Association Study (GWAS) of quantitative traits s... Read More about First Genome-Wide Association Study Investigating Blood Pressure and Renal Traits in Domestic Cats.

Risk factors and implications associated with renal mineralization in chronic kidney disease in cats (2022)
Journal Article
Tang, P., Jepson, R., Chang, Y., Geddes, R., Hopkinson, M., & Elliott, J. (2022). Risk factors and implications associated with renal mineralization in chronic kidney disease in cats. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16363

Background
Nephrocalcinosis is a pathological feature of chronic kidney disease (CKD). Its pathophysiological implications for cats with CKD are unexplored.

Objectives
Identify nephrocalcinosis risk factors and evaluate its influence on CKD prog... Read More about Risk factors and implications associated with renal mineralization in chronic kidney disease in cats.